A5009424808- Monoclonal and Polyclonal Antibodies Research
- Glycosylation and Glycoproteins Research
- HER2/EGFR in Cancer Research
- Cardiac Arrest and Resuscitation
- Multiple Myeloma Research and Treatments
- Platelet Disorders and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Autoimmune Bullous Skin Diseases
- Blood groups and transfusion
- Trauma and Emergency Care Studies
University of Michigan
2021-2023
Michigan United
2021-2023
BioSurfaces (United States)
2021-2022
Immune thrombocytopenia (ITP) is an acquired bleeding disorder characterized by immunoglobulin G (IgG)-mediated platelet destruction. Current therapies primarily focus on reducing antiplatelet antibodies using immunosuppression or increasing production with thrombopoietin mimetics. However, there are no universally safe and effective treatments for patients presenting severe life-threatening bleeding. The IgG-degrading enzyme of Streptococcus pyogenes (IdeS), a protease strict specificity...
The identification of antibody variable regions in the heavy (V H ) and light L chains from hybridomas is necessary for production recombinant, sequence-defined monoclonal antibodies (mAbs) derivatives. This process has received renewed attention recent reports having unintended specificities due to non-antigen specific and/or intended antigen. Here we report a surprising finding potential pitfall domain sequencing an anti-human CD63 hybridoma. We amplified multiple V genes hybridoma cDNA,...
To evaluate coagulofibrinolytic abnormalities and the effects of ART-123 (recombinant human thrombomodulin alpha) in a porcine model cardiac arrest prolonged cardiopulmonary resuscitation (CA/CPR).
Abstract The identification of antibody variable regions in the heavy (V H ) and light L chains from hybridomas is necessary for production recombinant, sequence-defined monoclonal antibodies (mAbs) derivatives. This process has received renewed attention recent reports having unintended specificities due to non-antigen specific and/or intended antigen. Here we report a surprising finding potential pitfall domain sequencing an anti-human CD63 hybridoma. We amplified multiple V genes...