A5055306969- Monoclonal and Polyclonal Antibodies Research
- Nanoplatforms for cancer theranostics
- SARS-CoV-2 and COVID-19 Research
- Glycosylation and Glycoproteins Research
- Advanced Nanomaterials in Catalysis
- Gold and Silver Nanoparticles Synthesis and Applications
- Radiopharmaceutical Chemistry and Applications
- Bacteriophages and microbial interactions
- HER2/EGFR in Cancer Research
- Multiple Myeloma Research and Treatments
- Nanoparticle-Based Drug Delivery
- Luminescence and Fluorescent Materials
- Dendrimers and Hyperbranched Polymers
- Medical Imaging Techniques and Applications
- Advanced biosensing and bioanalysis techniques
- COVID-19 Clinical Research Studies
- RNA Interference and Gene Delivery
- Chemical Reactions and Isotopes
- SARS-CoV-2 detection and testing
- Advanced Biosensing Techniques and Applications
Korea Advanced Institute of Science and Technology
2018-2024
BioSurfaces (United States)
2021-2023
University of Michigan–Ann Arbor
2021-2023
Pharmaceutical Biotechnology (Czechia)
2023
Michigan United
2021
We report the design of a novel microcapsule platform for in situ pH sensing and photothermal heating, which involves encapsulation pH-responsive polymer-coated molybdenum disulfide (MoS2) nanosheets (NSs) microcapsules with an aqueous core semipermeable polymeric shell. The MoS2 NSs were functionalized polymers having fluorescent groups at distal end to provide pH-sensitive Förster resonance energy transfer (FRET) effect. carefully designed produce dramatic change polymer conformation,...
Abstract The COVID‐19 pandemic continues to be a severe threat human health, especially due current and emerging SARS‐CoV‐2 variants with potential escape humoral immunity developed after vaccination or infection. development of broadly neutralizing antibodies that engage evolutionarily conserved epitopes on coronavirus spike proteins represents promising strategy improve therapy prophylaxis against thereof. Herein, facile multivalent engineering approach is employed achieve large...
Melanin-like nanoparticles decorated with gold are presented as cancer-targeting near-infrared (NIR) photothermal agents excellent conversion and stability.
Abstract Monoclonal antibodies that target SARS-CoV-2 with high affinity are valuable for a wide range of biomedical applications involving novel coronavirus disease (COVID-19) diagnosis, treatment, and prophylactic intervention. Strategies the rapid reliable isolation these antibodies, especially potent neutralizing critical toward improved COVID-19 response informed future to emergent infectious diseases. In this study, single B cell screening was used interrogate antibody repertoires...
SUMMARY The inability of antibodies and other biologics to penetrate the blood-brain barrier (BBB) is a key limitation their use in diagnostic, imaging, therapeutic applications. One promising strategy deliver IgGs using bispecific BBB shuttle, which involves fusing an IgG with second affinity ligand that engages cerebrovascular endothelial target facilitates transport across BBB. Nearly all prior efforts have focused on transferrin receptor (TfR-1) as prototypical despite inherent delivery...
The identification of antibody variable regions in the heavy (V H ) and light L chains from hybridomas is necessary for production recombinant, sequence-defined monoclonal antibodies (mAbs) derivatives. This process has received renewed attention recent reports having unintended specificities due to non-antigen specific and/or intended antigen. Here we report a surprising finding potential pitfall domain sequencing an anti-human CD63 hybridoma. We amplified multiple V genes hybridoma cDNA,...
Abstract The identification of antibody variable regions in the heavy (V H ) and light L chains from hybridomas is necessary for production recombinant, sequence-defined monoclonal antibodies (mAbs) derivatives. This process has received renewed attention recent reports having unintended specificities due to non-antigen specific and/or intended antigen. Here we report a surprising finding potential pitfall domain sequencing an anti-human CD63 hybridoma. We amplified multiple V genes...