Abstract Notch signaling has been extensively implicated in cell-fate determination along the development of immune system. However, a role for fully differentiated cells not clearly defined. We have analyzed expression protein family members during macrophage activation. Resting macrophages express Notch-1, -2, and -4, as well ligands Jagged-1 -2. After treatment with LPS and/or IFN-γ, we observed p38 MAPK-dependent increase Notch-1 mRNA levels. To study activation, forced transient...

Nowadays industrial robots are an appropriate technology for developing flexible and reconfigurable manufacturing systems which contribute to perform automatically operation such as milling, cutting, drilling, grinding, deburring polishing. Machining symbolize a cost-saving alternative compared conventional CNC machines the restricted working area produced shape limitations. The improvement of individual elements development new devices has caused perception change about use machining...

The Industry 4.0 era has resulted in several opportunities and challenges for the manufacturing industry small medium-sized enterprises (SME); technologies such as Internet of Things (IoT), Virtual Reality (VR) or Cloud Computing are changing business structures profound ways. A literature review shows that most large-sized have rolled out investment plans, some which reviewed during this research show investments companies exceed turnover SMEs all cases (<€50 million), makes access to...

Industry 4.0 in the contemporary operating context carries important sources of complexity. This generates both traditional risks and emerging that must be managed. The management these includes industrial occupational risks, since they are heavily interlinked. human factor can considered main link between types risks. Thus, understanding originating from errors organizational weaknesses as causes accidents other disruptions complex systems requires elaborating sophisticated modeling...

BackgroundMusculoskeletal disorders (MSDs) that result from poor ergonomic design are one of the occupational greatest concern in industrial sector. A key advantage primary phase is to focus on a method assessment detects and evaluates potential risks experienced by operative when faced with these types physical injuries. The will improve process identifying improvements various alternatives or activities undertaken as part cycle continuous improvement throughout differing phases product...

The lack of specific standards for characterization materials manufactured by Fused Deposition Modelling (FDM) makes the assessment applicability test methods available and analysis their limitations necessary; depending on definition most appropriate specimens kind part we want to produce or purpose data obtain from tests. In this work, Spanish standard UNE 116005:2012 international ASTM D638–14:2014 have been used characterize mechanically FDM samples with solid infill considering two...

Paleolithic rock art is one of the most important cultural phenomena in history mankind. It was made by making incisions and/or applying natural pigments mixed with water or organic elements on a surface, which for millennia has been subjected to different factors and anthropogenic alteration that have caused its deterioration disappearance. The present paper shows methodology employs hyperspectral technology range visible light near infrared spectrum, providing scientific non-destructive...

Gonadotrophin-releasing hormone analogues (GnRH-a) are currently used in combination with gonadotrophins ovarian stimulation for in-vitro fertilization (IVF). The present study evaluates follicular recruitment and outcome of IVF patients treated GnRH-a, starting different phases the menstrual cycle. Ovarian quiescence was achieved by s.c. injection a GnRH-a (600μg/day). Three groups were randomly established. Patients group 1 (n = 14) started treatment 4–7 days after ovulation. Women 2 15)...

The term additive manufacturing (AM) groups together a set of technologies with similar characteristics forming part the Fourth Industrial Revolution. AM is being developed globally, as evidenced by standards published and agreements between ISO ASTM in 2013. purpose this paper to anticipate main changes that will occur 2030 forecast more than 100 Spanish experts through Delphi prospection performed 2018. In way, areas, aspects, business models greatest probabilities occurrence are obtained....

Organizations strive to maximize efficiency in their manufacturing processes, yet they must also consider broader repercussions, as industrial activity directly impacts the environment and society. The adoption of innovative technologies initiatives mitigate this impact is therefore essential. Traditional asset maintenance plays a critical role ensuring high equipment availability, but there clear need evolve toward predictive sustainable strategies enhance reliability, safety, lifespan....

Besides traditional occupational risks, advanced manufacturing processes (AMP) can generate other risks described by the European Agency for Safety and Health at Work (EU-OSHA) as "new emerging risks" (NER) to safety health. Several studies have been carried out EU-OSHA in order identify all these risks. However, direct use of this set NER identification procedures generally applied labour particularly AMP, may result rather than NER, mainly because they defined without following a risk...

Rock art is one of the most fragile and relevant cultural phenomena in world history, carried out shelters or walls ceilings caves with mineral organic substances. The fact it has been preserved until now can be considered as fortunate since both anthropogenic natural factors cause its disappearance deterioration. This reason why rock needs special conservation protection measures. emergence digital technologies made a wide range tools programs available to community for more comprehensive...

Agile manufacturing systems work in a constantly changing global market, particularly assembly at the last stage of product differentiation. Meanwhile, sustainability is becoming key issue for strategy. This paper formulates systemic criterion agile and computes it through flexibility complexity. It defined as ratio utility entropy measurement. Under unified framework, allows one to quantify contributions agility, particular system flexibility. Complexity measured by entropy. Thus, an...

The use of current computer tools in both manufacturing and design stages breaks with the traditional conception productive process, including successive projection, representation, manufacturing. Designs can be programmed as problems to solved by using computational based on complex algorithms optimize produce more effective solutions. Additive technologies enhance these possibilities providing great geometric freedom materialization phase. This work presents a methodology for optimization...

Most of industrial heritage assets need new activities to ensure their survival. In addition, the collection is very broad, many locations have now become central and are targets for speculation, nature these sites displays great specialization. Consequently, processes reusing necessary conserve them, but they risk destroying features whose value has been inadequately identified. This work faces this multicriteria problem by adapting Analytic Hierarchy Process (AHP) create two independent...

Abstract Magnesium is one of the lightest metallic materials and used in industries such as aeronautics or aerospace because its excellent weight to resistance ratio. The surface finish a key quality characteristic dry turning magnesium pieces often affected by multiple factors within machining process. Factors feed rate, cutting speed, tool coatings, interactions among these were investigated this experimental study. objectives work identify main that influence select optimal manufacturing...

All projects take place within a context of uncertainty. That is especially noticeable in complex hydroelectric power generation projects, which are affected by factors such as the large number multidisciplinary tasks to be performed parallel, long execution times, or risks inherent various fields like geology, hydrology, and structural, electrical, mechanical engineering, among others. Such often lead cost overruns delays this type. This paper analyzes efficiency Earned Value Management...

Additive manufacturing technologies offer important new possibilities, but its potential is so big that only with the support of other can it really be exploited. In sense, parametric design and optimization tools appear as two appropriate complements for additive manufacturing. Synergies existing between these three allow integrated approaches to customized optimized products. While makes possible materialize overly complex geometries, allows designs adapted custom characteristics helps...

Equal channel angular extrusion or pressing (ECAE ECAP) is a process used in order to impart severe plastic deformations processed materials with the aim of improving their mechanical properties by reducing grain size. The size reduction leads improvement. In present study, new die configuration proposed for ECAE process. advantage this geometry that it allows us obtain higher strain each passage than traditional dies. It important optimize geometry, as main materials. Consequently,...