A5040326808- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Adolescent and Pediatric Healthcare
- Digital Mental Health Interventions
- Mental Health Research Topics
- Suicide and Self-Harm Studies
- GABA and Rice Research
- Visual Attention and Saliency Detection
- Circadian rhythm and melatonin
- COVID-19 and Mental Health
- Identity, Memory, and Therapy
- Visual perception and processing mechanisms
- Telemedicine and Telehealth Implementation
- Virtual Reality Applications and Impacts
- Genetic Associations and Epidemiology
- Nuclear Receptors and Signaling
- Attention Deficit Hyperactivity Disorder
- Health, Environment, Cognitive Aging
- Neurotransmitter Receptor Influence on Behavior
- Psychosocial Factors Impacting Youth
- Religion, Spirituality, and Psychology
- PI3K/AKT/mTOR signaling in cancer
- Personality Disorders and Psychopathology
- Genetic Neurodegenerative Diseases
- Nicotinic Acetylcholine Receptors Study
Karolinska Institutet
2023-2024
Semmelweis University
2019-2023
Stockholm University
2021-2022
Pázmány Péter Catholic University
2019-2021
The capacity to elicit vivid visual mental images varies within an extensive range across individuals between hyper- and aphantasia. It is not clear, however, whether imagery vividness constant the lifespan or changes during development later in life. Without enforcing constraints of strict experimental procedures representativity entire population, our purpose was explore self-reported level determine relative proportions aphantasic/hyperphantasic participants different age groups. Relying...
Environmental stress and its interaction with genetic variation are key contributors in the development of depression anxiety, yet there is a failure to identify replicable variants gene-interaction effects background these psychiatric symptoms. Recently it has been reported that 5-HTTLPR NOSI interact financial but not other types recent stressors depression. In present study we investigated GABRA6 rs3219151 CNR1 rs7766029 different life events on presence anxiety large general population...
Abstract Suicide is a global issue accounting for more than 700,000 deaths annually, with low- and middle-income countries being disproportionally affected. Technology-enhanced interventions have been suggested as preventive method various benefits—e.g., increased scalability sustainability, making them relevant developed especially developing nations. However, despite the increasing number of such interventions, their effectiveness seldom appropriately evaluated. The current review aims to...
Lack of proper consideration an the interaction between biological and environmental factors limits our understanding development depression. Our cross-sectional study investigated how whether recent stress influences effect affective temperaments on depressive symptoms. Methods: 1015 general population subjects participants completed Brief Symptom Inventory to capture symptoms, List Threatening Experiences Questionnaire assess stressors, Temperament Evaluation Memphis Pisa, Paris San Diego...
Emotional stress is a leading risk factor in the development of neuropsychiatric disorders possibly via immune activation. P2X7 receptors promote neuroinflammation, and research suggests relationship between chromosome region 12q2431, which P2X7R gene located, mood disorders, however, few studies concentrate on its association with anxiety. Our aim was to investigate effects P2RX7 variation interaction early childhood traumas recent stressors 1752 participants completed questionnaires...
Both early childhood traumatic experiences and current stress increase the risk of suicidal behaviour, in which immune activation might play a role. Previous research suggests an association between mood disorders
The P2X purinoceptor 7 (P2RX7) mediates inflammatory microglial responses and is implicated in neuroimmune mechanisms of depression neurodegenerative disorders. A number studies suggest that psychosocial stress may precipitate through immune activation. Genetic association P2RX7 variants with have been inconclusive. However, nearly all focused on only one single-nucleotide polymorphism (SNP) not considered interaction stress. We investigated the effect several variations gene using a...
The role of circadian dysregulation is increasingly acknowledged in the background depressive symptoms, and also a promising treatment target. Similarly, stress shows complex relationship with system. CLOCK gene, encoding key element regulation has been implicated previous candidate variant studies depression contradictory findings, only few such considered interacting effects stress. We investigated effect variation linkage-disequilibrium-based clumping method, interaction childhood...
Background: Understanding and predicting suicide remains a challenge, recent paradigm shift regarding the complex relationship between immune system brain brought attention to involvement of inflammation in neuropsychiatric conditions including suicide. Among cytokines, IL-6 has been most frequently implicated suicide, yet only few candidate gene studies without considering effect stress investigated role IL6 suicidal behaviour. Our study aimed investigate association variation with linkage...
Background: Suicide is among the leading causes of death in adolescents and young adults, however, its neurobiological etiology still not understood. In spite original reports concerning involvement 5-HTTLPR, interaction with recent stress appearance suicidal ideation attempts replication have yielded contradictory results. our study we analysed association between lifetime suicide current ideation, hopelessness thoughts as main effects childhood adversities, different types life events a...
Abstract Introduction The final aim of the EXPERIENCE project is to enable individuals record and share extended-personal realities in Virtual Reality (VR) - which entails consideration a person’s neurophysiological, psychological, cognitive states. One prospective application using this technology aid assessing symptoms affective disorders. Objectives objective test ability pre-designed VR environment differentiate between with depressive healthy controls (HCs) via machine learning...
Introduction Although suicide claims more lives than war and homicide, we still have no sufficient effective methods either for its prediction or prevention. Our screening are laborous subjective both on the side of patient clinician. Understanding genetic background suicidal behaviour would help identify biomarkers as well pathways potential targets novel intervention prevention approaches. However, in spite a number GWAS studies, results few rarely replicate, generally accurate phenotyping...
Introduction The presence of eating disorders is often associated with serious physical complications, self-destruction, and suicidal tendencies. Furthermore, may present as a symptom or in comorbidity personality disorders. In order to treat disorder patients successfully we need more complex individual approach taking into consideration the specific dysfunctions traits patient underlying symptomatic manifestations. Recently paradigm shift conceptualisation led introduction dimensional...
<sec> <title>BACKGROUND</title> There is a clear need for enhanced mental health assessment, depressive symptom evaluation being no exception. A promising approach to this aim utilising Virtual Reality (VR), that entails the potential of adding wider set assessment domains with ecological validity. However, whilst several studies have utilised VR both diagnostic and treatment purposes, its acceptance, in particular how exposure virtual environments affect populations psychiatric conditions...
There is a clear need for enhanced mental health assessment, depressive symptom (DS) evaluation being no exception. A promising approach to this aim using virtual reality (VR), which entails the potential of adding wider set assessment domains with ecological validity. However, whilst several studies have used VR both diagnostic and treatment purposes, its acceptance, in particular how exposure environments affects populations psychiatric conditions remains unknown. This study aims report on...
Introduction The EXPERIENCE project aims to enable the creation and sharing of extended-personal realities in virtual reality (VR). Currently, software hardware technology are under development, that will automatically generate VR environments based on neurophysiological, psychological, cognitive, behavioral data support not only recording personal experiences but transmission as well another user. Potential use cases include enhanced treatment assessment symptom severity affective...
Abstract The capacity to elicit vivid visual mental images varies within an extensive range across individuals between hyper- and aphantasia. It is not clear, however, whether imagery vividness constant the lifespan or changes during development later in life. Without enforcing constraints of strict experimental procedures representativity entire population, our purpose was take a first look at self-reported level determine relative proportion aphantasic/hyperphantasic participants different...