A5049806794- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Heme Oxygenase-1 and Carbon Monoxide
- Mitochondrial Function and Pathology
- Chromosomal and Genetic Variations
- Retinal and Macular Surgery
- Botulinum Toxin and Related Neurological Disorders
- Hedgehog Signaling Pathway Studies
- Epilepsy research and treatment
- Alzheimer's disease research and treatments
- Porphyrin Metabolism and Disorders
- Vagus Nerve Stimulation Research
- Photoacoustic and Ultrasonic Imaging
- Congenital limb and hand anomalies
- Vascular Malformations Diagnosis and Treatment
- Vascular Malformations and Hemangiomas
- Genomic variations and chromosomal abnormalities
- Nanoplatforms for cancer theranostics
- Metabolism and Genetic Disorders
- Lung Cancer Treatments and Mutations
- Glioma Diagnosis and Treatment
The University of Texas at Dallas
2016-2019
The University of Texas Health Science Center at Houston
2017
Since Otto Warburg made the first observation that tumor cells exhibit altered metabolism and bioenergetics in 1920s, many scientists have tried to further understanding of bioenergetics. Particularly, past decade, application state-of the-art metabolomics genomics technologies has revealed remarkable plasticity Firstly, a wide array been shown be able use not only glucose, but also glutamine for generating cellular energy, reducing power, metabolic building blocks biosynthesis. Secondly,...
Vascular disrupting agents (VDAs) represent a promising class of anti-cancer drugs for solid tumor treatment. Here, we aim to better understand the mechanisms underlying reccurrence and treatment resistance following administration VDA, combretastatin A-4 phosphate (CA4P). Firstly, used photoacoustic tomography noninvasively map effect CA4P on blood oxygen levels throughout subcutaneous non-small cell lung cancer (NSCLC) tumors in mice. We found that oxygenation peripheral vessels was...
Abstract Lung cancer remains the leading cause of cancer-related death, despite advent targeted therapies and immunotherapies. Therefore, it is crucial to identify novel molecular features unique lung tumors. Here, we show that cyclopamine tartrate (CycT) strongly suppresses growth subcutaneously implanted non-small cell (NSCLC) xenografts nearly eradicated orthotopically NSCLC xenografts. CycT reduces heme synthesis degradation in cells oxygen consumption purified mitochondria. In...
Heme is a central molecule in mitochondrial respiration and ATP generation neuronal cells. Thus, we assessed the importance of altered heme metabolism Alzheimer's disease (AD) pathogenesis.To investigate role AD, identified heme-related proteins whose expression AD patients mouse models exhibiting amyloid pathology. We detected levels involved synthesis, uptake, degradation, function during differentiation characterized effects Aβ.We found that rate-limiting synthetic enzyme ALAS1...
Objective: A young male presented with an ischemic stroke and was found to have clinical features of PHACE syndrome. Background: represents a syndromic constellation Posterior fossa malformations, facial Hemangiomas, cerebral Arterial anomalies, Cardiovascular Eye abnormalities. Steno-occlusive disease causing secondary complications like arterial moya-moya vasculopathy can be seen in affected individuals. Design/Methods: Single case report. Results: 36 year old history left eye retinal...
We identified that patients with initially palliative vagal nerve stimulator (VNS) placement who subsequently lateralized their epilepsy sufficiently for resective surgery.
Mitochondrial dysfunction and bioenergetics deficits have been identified as an early potentially causative event in AD pathogenesis. heme is a key factor mitochondrial function bioenergetics. Heme central metabolic signaling molecule regulating diverse molecular cellular processes. Thus, we assessed the importance of altered metabolism amyloid β (Aβ) action Alzheimer's disease (AD) To investigate role AD, heme-related proteins whose expression patients mouse models exhibiting pathology....