A5100443309- Cancer, Hypoxia, and Metabolism
- Ubiquitin and proteasome pathways
- Metabolomics and Mass Spectrometry Studies
- Protein Degradation and Inhibitors
- Cancer, Lipids, and Metabolism
- Prostate Cancer Treatment and Research
- Mitochondrial Function and Pathology
- Chronic Kidney Disease and Diabetes
- Autophagy in Disease and Therapy
- ATP Synthase and ATPases Research
- Amino Acid Enzymes and Metabolism
- Erythropoietin and Anemia Treatment
- Drug-Induced Hepatotoxicity and Protection
- Blood properties and coagulation
- Drug Transport and Resistance Mechanisms
- Epigenetics and DNA Methylation
- Liver Disease and Transplantation
Yonsei University
2021-2024
Korea Pharma (South Korea)
2021
National Cancer Research Institute
2019
National Cancer Center
2018-2019
The University of Queensland
2006
Abstract Anticancer drug resistance is a major challenge of cancer therapy. We found that irinotecan-resistant NSCLC cells showed increased mitochondrial oxidative phosphorylation compared to the sensitive cells. Previously, we combined inhibition aldehyde dehydrogenase using gossypol, and complex I phenformin, effectively reduced in NSCLC. Here, targeting with gossypol phenformin abrogated irinotecan Furthermore, treatment by blocking induced synergistic anti-cancer effect The pre-clinical...
Abstract The major source of ATP in cancer cells remains unclear. Here, we examined energy metabolism gastric and found increased fatty acid oxidation expression ALDH3A1. Metabolic analysis showed that lipid peroxidation by reactive oxygen species led to spontaneous production 4-hydroxynonenal, which was converted acids with NADH ALDH3A1, resulting further oxidation. Inhibition ALDH3A1 knock down using siRNA resulted significantly reduced cells, leading apoptosis. Oxidative phosphorylation...
Fast growing cancer cells require greater amounts of ATP than normal cells. Although glycolysis was suggested as a source anabolic metabolism based on lactate production, the main to support cell remains unidentified.We have proposed that oxoglutarate carrier SLC25A11 is important for production in by NADH transportation from cytosol mitochondria malate. We examined not only changes and but also metabolites after knock down cells.The mitochondrial electron transport chain functionally active...
The androgen receptor (AR) is an attractive target for treating prostate cancer, considering its role in the development and progression of localized metastatic cancer. high global mortality burden despite medical treatments such as deprivation or AR antagonist therapy, highlights need to explore alternative strategies. One strategy involves use heterobifunctional degraders, also known proteolysis-targeting chimeras, which are novel small-molecule therapeutics that inhibit amplified mutated...
Sulfate is required for detoxification of xenobiotics such as acetaminophen (APAP), a leading cause liver failure in humans. The NaS1 sulfate transporter maintains blood levels sufficiently high sulfonation reactions to work effectively drug detoxification. In the present study, we identified two loss-of-function polymorphisms human gene and showed Nas1-null mouse be hypersensitive APAP hepatotoxicity. treatment led increased damage decreased hepatic glutathione hyposulfatemic mice compared...
In general, expression of transglutaminase 2 (TGase 2) is upregulated in renal cell carcinoma (RCC), resulting p53 instability. Previous studies show that TGase binds to and transports it the autophagosome. Knockdown or inhibition RCC induces p53-mediated apoptosis. Here, we screened a chemical library for inhibitors identified streptonigrin as potential therapeutic compound RCC. Surface plasmon resonance mass spectroscopy were used measure binding 2. Mass spectrometry analysis revealed...
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Fear of crime is one the most significant factors affecting citizen's quality life. It particularly necessary to control environmental that cause fear in neighborhood, as more worrisome. This study aimed investigate women's public streets their neighborhoods and identify affect using a questionnaire an eye-tracking experiment, respectively. Thirty participants watched four low-rise residential Seoul responded survey about crime. Through multiple regression analysis, Factors such...
Background: The major source of ATP in cancer cells remains unclear. Mainly, use glucose for lactate production and biomaterial synthesis through the pentose phosphate one carbon pathways. Here, we examined energy metabolism gastric found increased fatty acid oxidation expression ALDH3A1. We then performed metabolite mass analysis to examine whether ALDH3A1 plays a key role supplying NADH by cells.Method: Changes abundance metabolites, including ATP, were measured spectrometry after genetic...