A5022470933- Genomics, phytochemicals, and oxidative stress
- Biochemical Acid Research Studies
- Inflammatory Bowel Disease
- Helicobacter pylori-related gastroenterology studies
- Sarcoidosis and Beryllium Toxicity Research
- Vitamin C and Antioxidants Research
- Tuberculosis Research and Epidemiology
- Immunodeficiency and Autoimmune Disorders
- Pulmonary Hypertension Research and Treatments
- Transplantation: Methods and Outcomes
- Intraoperative Neuromonitoring and Anesthetic Effects
- Glutathione Transferases and Polymorphisms
- Anesthesia and Pain Management
- Vascular Anomalies and Treatments
- Digestive system and related health
- Nausea and vomiting management
Toronto Western Hospital
2018
University Health Network
2018
University of Toronto
2011
Hospital for Sick Children
2011
SickKids Foundation
2011
Carleton University
2009-2011
Background Nrf1 (nuclear factor-erythroid 2 p45 subunit-related factor 1) is a transcription mediating cellular responses to xenobiotic and pro-oxidant stress. regulates the of many stress-related genes through electrophile response elements (EpREs) located in their promoter regions. Despite its potential importance human health, mechanisms controlling have not been addressed fully. Principal Findings We found that proteasomal inhibitors MG-132 clasto-lactacystin-β-lactone stabilized protein...
In mammals, aging is linked to a decline in the activity of citrate synthase (CS; E.C. 2.3.3.1), first enzyme citric acid cycle. We used 2,2′-azobis(2-amidinopropane) dihydrochloride (AAPH), water-soluble generator peroxyl and alkoxyl radicals, investigate susceptibility CS oxidative damage. Treatment isolated mitochondria with AAPH for 8–24 h led inactivation; however, aconitase, mitochondrial routinely as an stress marker, was unaffected. addition inactivation, treatment purified resulted...
We present a case of high cardiac output (CO) arteriovenous fistula (AVF) with pulmonary hypertension (PH) post-double lung transplant presenting for AVF occlusion. The patient presented CO 9.83 L/min, artery pressures 64/16, inferior vena cava dilatation and an between the left common iliac vein. Given her anaesthetic considerations, we elected to proceed local anaesthesia sedation. Trial balloon occlusion resulted in increase blood pressure headache that resolved deflation. Successful...