A5085515749- Ultrasound and Hyperthermia Applications
- Ultrasound Imaging and Elastography
- Photoacoustic and Ultrasonic Imaging
- Barrier Structure and Function Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Vagus Nerve Stimulation Research
- S100 Proteins and Annexins
- Digestive system and related health
- Ultrasound and Cavitation Phenomena
- Cell Image Analysis Techniques
- Advanced MRI Techniques and Applications
- 3D Printing in Biomedical Research
- Epilepsy research and treatment
- Photoreceptor and optogenetics research
- Neuroscience and Neural Engineering
- Molecular Communication and Nanonetworks
- Single-cell and spatial transcriptomics
- Extracellular vesicles in disease
- Glioma Diagnosis and Treatment
- Wireless Power Transfer Systems
- Bioinformatics and Genomic Networks
- Neuroinflammation and Neurodegeneration Mechanisms
- Infrared Thermography in Medicine
- Gene expression and cancer classification
- Virus-based gene therapy research
Columbia University
2020-2025
Background: Focused ultrasound (FUS)-mediated blood-brain barrier (BBB) opening is a noninvasive, safe and reversible technique for targeted drug delivery to the brain. Most preclinical systems developed perform monitor BBB are comprised of separate geometrically focused transducer passive cavitation detector (PCD) or imaging array. This study builds upon previous work from our group developing single phased array configuration simultaneous monitoring called theranostic (ThUS), leveraging...
Abstract Focused Ultrasound (FUS) paired with systemically-injected microbubbles (μB) is capable of transiently opening the blood–brain barrier (BBBO) for noninvasive and targeted drug delivery to brain. FUS-BBBO also modulating neuroimmune system, further qualifying its therapeutic potential neurodegenerative diseases like Alzheimer’s disease (AD). Natural aging AD impose significant strain on brain particularly BBB, modifying structure subsequently, functionality. The emerging focus...
Abstract Focused ultrasound (FUS) with microbubbles opens the blood-brain barrier (BBB) to allow targeted drug delivery into brain. The mechanisms by which endothelial cells (ECs) respond either low acoustic pressures known open BBB transiently, or high that cause brain damage, remain incompletely characterized. Here, we use a mouse strain where tight junctions between ECs are labelled eGFP and apply FUS at (450 kPa) (750 pressures, after mice sacrificed 1 72 hours. We find EC response...
ABSTRACT Gene therapy for neurodegenerative diseases faces significant challenges due to the blood-brain barrier (BBB), which limits drug delivery central nervous system (CNS). While clinical trials Parkinson’s disease (PD) have progressed, administration of vectors expressing enzymatic or neurotrophic factor transgenes required extensive optimization method achieve potentially therapeutic levels transgene expression. Focused ultrasound (FUS) combined with microbubbles has emerged as a...
Focused ultrasound (FUS) for blood-brain barrier (BBB) opening is a safe, reversible and non-invasive strategy targeted drug delivery to the brain, however extensive pre-planning strategies are necessary successful FUS-mediated BBB through structurally complex primate skull. <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Objective:</i> This study aims demonstrate pipeline consisting of transcranial simulations...
The BRICHOS domain is found in human precursor proteins associated with cancer, dementia (Bri2) and amyloid lung disease (proSP-C). Recombinant (rh) proSP-C Bri2 domains delay amyloid-β peptide (Aβ) fibril formation reduce toxicity vitro their overexpression reduces Aβ neurotoxicity animal models of Alzheimer's disease. After intravenous administration wild-type mice, rh Bri2, but not proSP-C, was detected the brain parenchyma, suggesting that selectively bypasses blood-brain barrier (BBB)....
The amyloid-β (Aβ) hypothesis implicates Aβ protein accumulation in Alzheimer's disease (AD) onset and progression. However, therapies targeting have proven insufficient achieving reversal, prompting a shift to focus on early intervention alternative therapeutic targets. Focused ultrasound (FUS) paired with systemically-introduced microbubbles (μB) is non-invasive technique for targeted transient blood-brain barrier opening (BBBO), which has demonstrated tau reduction, as well memory...
Neuroimmunomodulation is a promising form of drug-free treatment for neurological diseases ranging from Alzheimer’s disease to depression. The evidence supporting the efficacy focused ultrasound (FUS) neuroimmunomodulation encouraging; however, method has yet be standardized, and its mechanism remains poorly understood. Methods FUS can categorized into three paradigms based on parameters used. In first paradigm, blood–brain barrier opening (FUS-BBBO) combines with microbubbles (MB)...
Abstract Background Focused ultrasound (FUS)‐induced blood‐brain barrier opening (BBBO) is a technique for safely, non‐invasively, and transiently the blood brain in targeted area of brain. Pre‐clinical clinical studies have shown that FUS capable decreasing amyloid plaque load stimulating neurogenesis Alzheimer’s Disease (AD) models, addition to being safe use human patients. However, effect FUS‐BBBO on neurons has not yet been characterized, despite its crucial role cognition regulating...
Abstract Background Focused Ultrasound‐induced Blood‐Brain Barrier Opening (FUS‐BBBO) has demonstrated preventative and therapeutic efficacy for improving cognitive pathological decline in Alzheimer’s Disease (AD). Previous work highly specific binding of a novel Re complex (Re‐1) to amyloid‐β (Aβ) vitro , subsequently inhibiting fibril formation reducing Aβ‐induced cytotoxicity neuronal cell cultures. The aim this preliminary study is evaluate the early intervention combining FUS‐BBBO Re‐1...
Focused Ultrasound (FUS) is capable of opening the Blood-Brain Barrier (BBBO) in a reversible and targeted manner for purposes drug delivery neuroimmune modulation. FUS-BBBO has been used to reduce Alzheimer's Disease (AD)-associated pathologies murine models progressed AD, however new discoveries about role AD pathology disease onset progression motivates an investigation into factors upstream accumulation. Here we investigate ability monthly sessions preventing male female 3xTg mice. Four...
In this talk, I will discuss the challenges of performing neuronavigation-guided blood–brain barrier opening in human subjects. describe simulation framework required for treatment planning and hardware needed to achieve targeted therapies.
Focused Ultrasound (FUS) paired with systemically-introduced microbubbles (MB) is a widely-used noninvasive technique for transiently opening the Blood-Brain Barrier (BBB). FUS-BBBO implicated in treatment of several age-associated neuropathological disorders. The prevalence these diseases aged populations necessitates an investigation into and understanding effect age on brain's response to FUS-BBBO. Here we show that advanced natural aging increases susceptibility by increasing volume BBBO...
Theranostic Ultrasound (TUS) is a novel modality for combined blood-brain barrier (BBB) opening and cavitation mapping within single multielement imaging transducer. While previous work developing TUS has focused on understanding qualitative spatial agreement of strategy called power with regions BBB indicated contrast-enhanced magnetic resonance images (MRI), the impact short pulse lengths signal intensity yet to be resolved. In this study we evaluated volume, intensity, closure rapid beam...