A5079994412- Sarcoidosis and Beryllium Toxicity Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Plant Pathogens and Fungal Diseases
- Solid-state spectroscopy and crystallography
- Infectious Diseases and Tuberculosis
- Agricultural Science and Fertilization
- Medical Imaging and Pathology Studies
- Plant pathogens and resistance mechanisms
- Agronomic Practices and Intercropping Systems
- Climate variability and models
- Pneumocystis jirovecii pneumonia detection and treatment
- Meteorological Phenomena and Simulations
- Semiconductor Quantum Structures and Devices
- Crop Yield and Soil Fertility
- Rice Cultivation and Yield Improvement
- Agricultural Economics and Practices
- Research on Leishmaniasis Studies
- Plant Virus Research Studies
- Autoimmune and Inflammatory Disorders
- Plant Pathogenic Bacteria Studies
- Atmospheric aerosols and clouds
- Parasites and Host Interactions
- Agricultural pest management studies
- Eosinophilic Disorders and Syndromes
- Banana Cultivation and Research
All India Institute of Medical Sciences Rishikesh
2025
Bolton NHS Foundation Trust
2024
Newcastle University
2023
Sri Karan Narendra Agriculture University, Jobner
2001-2023
Government Medical College
1964-2023
Manipal Academy of Higher Education
2023
Navsari Agricultural University
2018-2023
ICMR National Institute for Research in Environmental Health
2023
Indian Institute of Soil Science
2023
Indian Veterinary Research Institute
1998-2021
Metabolism of [3H]25-hydroxyvitamin D3(25-OH-D3) was studied in primary cultures pulmonary alveolar macrophages (PAM) from seven patients with sarcoidosis and two idiopathic fibrosis. Production a [3H]1,25-dihydroxyvitamin D3 (1,25-[OH]2-D3)-like metabolite [3H]25-OH-D3 detected lipid extracts cells five sarcoidosis. Synthesis this compound vitro limited to viable PAM greatest derived patient hypercalcemia an elevated serum concentration 1,25-dihydroxyvitamin D. The tritiated coeluted...
ABSTRACT. Hypercalcemia and hypercalciuria in sarcoidosis are thought to result from the endogenous overproduction of an active vitamin D metabolite. We employed primary cultures pulmonary alveolar macrophages two patients with biopsy-proven a recent or current clinical abnormality calcium metabolism synthesize vitro 1,25- dihydroxyvitamin D3 [l,25-(OH)2D3]-like metabolite 25-hydroxyvitamin (25OHD)3. The macrophage co- chromatographed [3(H]i,25-(OH)2D3 on normal phase reverse high...
To assess the efficacy of chloroquine (Aralen) phosphate and hydroxychloroquine (Plaquenil) sulfate in treatment patients with neurosarcoidosis who either do not respond to corticosteroid therapy or develop unacceptable side effects.Retrospective study.Sarcoidosis clinic at a university teaching hospital.Twelve biopsy-proved sarcoidosis, 6 women men ranging from 20 49 years age, neurological involvement.Chloroquine phosphate, 250 mg twice daily, sulfate, 200 was administered for period 21...
Ketoconazole is an antifungal agent capable of inhibiting human steroid hormone synthesis, including renal 1,25-dihydroxyvitamin D [1,25-(OH)2D] synthesis. The ability this drug to inhibit the extrarenal production 1,25-(OH)2D, as occurs in granuloma-forming disease states, sarcoidosis, has not been evaluated. We examined effect ketoconazole on l,25-(OH)2D-calcium homeostatic mechanism a hypercalcemic patient with sarcoidosis and synthesis 1,25-(OH)2D3in vitro by cultured pulmonary alveolar...
In this retrospective study, we attempted to identify early in the course of septic shock hemodynamic variables that differ between survivors and nonsurvivors. We examined records 78 patients with from our medical ICU (40 38 nonsurvivors). Significant differences were found cardiac index (CI) (4.07 +/- 0.25 vs. 2.98 L/min.m2) oxygen delivery (DO2) (15.6 0.7 12.7 0.8 ml/min.kg) at 48 h surviving nonsurviving patients. Furthermore, an analysis relationship DO2 VO2 suggests a critical level be...
A trade-factor-based system study has been carried out to identify fuel burn benefits associated with boundary layer ingestion (BLI) for generation-after-next (N+2) aircraft and propulsion concepts. The analysis includes detailed engine cycle modeling a next-generation, Ultra-High-Bypass (UHB) BLI using the Numerical Propulsion System Simulation (NPSS) computational model. Cycle was supplemented one-dimensional theory limiting theoretical blended wing body reference vehicle used in study....
Protein-peptide interactions, where one partner is a globular protein (domain) and the other flexible linear peptide, are key components of cellular processes predominantly in signaling regulatory networks, hence prime targets for drug design. To derive details protein-peptide interaction mechanism often cumbersome task, though it can be made easier with availability specific databases tools. The Peptide Binding Protein Database (PepBind) curated searchable repository structures, sequences...
BCR-ABL tyrosine kinase plays a major role in the pathogenesis of chronic myeloid leukemia (CML) and is proven target for drug development. Currently available drugs market are effective against CML; however, side-effects drug-resistant mutations limit their full potential. Using high throughput virtual screening approach, we have screened several small molecule databases docked wild-type resistant T315I mutant BCR-ABL. Drugs that currently available, such as imatinib ponatinib, were also...
Immunotherapy has become increasingly popular in recent years for treating a variety of diseases including inflammatory, neurological, oncological, and auto-immune disorders. The significant interest antibody development is due to the high binding affinity specificity an against specific antigen. Recent advances engineering have provided different view on how engineer antibodies silico therapeutic diagnostic applications. In order improve clinical utility antibodies, it paramount importance...