A5100647090- Metal complexes synthesis and properties
- Free Radicals and Antioxidants
- Mosquito-borne diseases and control
- Synthesis and biological activity
- Sphingolipid Metabolism and Signaling
- Calcium signaling and nucleotide metabolism
- Lanthanide and Transition Metal Complexes
- Biochemical and Molecular Research
- Animal Virus Infections Studies
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Insect symbiosis and bacterial influences
- Bioactive Compounds and Antitumor Agents
- Chronic Myeloid Leukemia Treatments
- Venomous Animal Envenomation and Studies
- Hepatitis C virus research
- Phytochemistry and Bioactive Compounds
- HIV/AIDS drug development and treatment
- Nanoparticles: synthesis and applications
- Lysosomal Storage Disorders Research
- Enzyme Structure and Function
- Hepatitis B Virus Studies
- Trypanosoma species research and implications
- Quinazolinone synthesis and applications
- Studies on Chitinases and Chitosanases
- Animal health and immunology
Saveetha University
2023-2025
Pondicherry University
2012-2024
Alsalam University College
2017
Uniformed Services University of the Health Sciences
2015
Uttar Pradesh Pandit Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go-Anusandhan Sansthan
2015
University of Mysore
2003
Indian Institute of Chemical Technology
1997
BCR-ABL tyrosine kinase plays a major role in the pathogenesis of chronic myeloid leukemia (CML) and is proven target for drug development. Currently available drugs market are effective against CML; however, side-effects drug-resistant mutations limit their full potential. Using high throughput virtual screening approach, we have screened several small molecule databases docked wild-type resistant T315I mutant BCR-ABL. Drugs that currently available, such as imatinib ponatinib, were also...
ZnONPs were synthesized using ferulic acid as the reductant and intricate twofold role DNA binders radio sensitizers was revealed, which can pave way for anticancer therapy.
Vernonia cinerea (L.) Less [Compositae (Asteraceae)] is used traditionally for several medical purposes such as inflammation, pain, fever, and cancer.The present study identified the bioactive constituents in methanol extract of leaf evaluated its antioxidant activity acute toxicity.The identification phytochemicals was accomplished by GC-MS major phenolic compounds were quantified HPTLC analysis. To quantify essential elements, atomic absorption spectrophotometeric analysis carried out....
Lymphatic filariasis (Lf) is one of the oldest and most debilitating tropical diseases. Millions people are suffering from this prevalent disease. It estimated to infect over 120 million in at least 80 nations world through subtropical regions. More than billion danger getting affected with life-threatening Several studies were suggested its emerging limitations resistance towards available drugs therapeutic targets for Lf. Therefore, better medicine drug demand. We took an initiative...
Abstract Aldoximes undergo rapid dehydration with H2SO4/ SiO2 solid support, under microwave irradiation in dry media to afford nitriles high yields. †IICT Communication No: 3645 Notes Commercial sulfuric acid (99%, 5 ml) was stirred a suspension of silica gel (Merck, mean particle size 10–40 μ) acetone (50 for 20 minutes. The catalyst obtained after filtration dried (70°/20 torr, 1 hr) before use (58.6 g, free flowing powder).
Viper envenomation undeniably induces brutal local manifestations such as haemorrhage, oedema and necrosis involving massive degradation of extracellular matrix at the bitten region many a times results in dangerous systemic haemorrhage including pulmonary shock. Snake venom metalloproteases (SVMPs) are being considered to be primary culprits for venom-induced haemorrhage. As consequence, researchers medical practitioners deliberate quest SVMP inhibitors. In this study, we evaluated...
Oxidative stress (OS) has been attributed to the progression of various disorders, including cancer, diabetes, and cardiovascular diseases. Several antioxidant compounds free radical quenchers have shown mitigate oxidative stress. However, large-scale randomized controlled trials such on chronic disease aversion yielded paradoxical disappointing results due constrained cognizance their mechanisms therapeutic targets. The current study sought identify potential targets 7,8-Dihydroxyflavone...
The ability of seed extracts Trigonella foenum-graecum (T. foenum-graecum) and Cuminum cyminum (C. cyminum) to act as natural coagulants was tested using turbid water. Seed were prepared distilled water NaCl (0.5 M 1.0 M) solution. Only extract T. had coagulation capability did not depend on pH values. Further it showed that coagulant obtained from is temperature (upto 100?C) stable (pH 4.0 - 10.0). Extract C. very minimal (16 ± 2) property. about 80% properties, where the best known such...
The mortality rate due to snakebite is reduced markedly by the use of anti-venoms, which are only medically approved remedial agents available. anti-venoms effectively neutralize systemic toxicity but offer no protection towards local tissue degradation. In viperid snake envenomations, SVMPs and SVHYs major responsible for brutal damage as they degrade ECM basement membrane surrounding blood vessels. Thus, usage inhibitor(s) against degrading enzymes in treatment viper bites an affirmative...
Phosphoglycerate mutase catalyzes the interconversion between 2-phosphoglycerate and 3-phosphoglycerate in glycolytic gluconeogenic pathways. They exist two unrelated forms, that is either cofactor (2,3-diphosphoglycerate) dependent or cofactor-independent. These enzymes have no similarity amino acid sequence, tertiary structure, catalytic mechanism. Wuchereria bancrofti (WB) contains cofactor-independent form, whereas other organisms can possess form both. Since, independent...
Viral Protein Database is an interactive database for three dimensional viral proteins.Our aim to provide a comprehensive resource the community of structural virology, with emphasis on description derived data from biology.Currently, VPDB includes ~1,670 protein structures >277 viruses more than 465 virus strains.The whole can be easily accessed through user convenience text search.Interactivity has been enhanced by using Jmol, WebMol and Strap visualize molecular structure.
Adefovir is an adenosine analogue approved by the Food and Drug Administration for treatment of chronic hepatitis B. Mutations occurring in B virus (HBV) reverse transcriptase (rt) domains are shown to confer resistance antiviral drugs. The role rtI233V mutation adefovir remains contradictory. In this study, it was attempted evaluate impact putative substitution on action homology modeling docking studies. HBVrt nucleotide sequence containing obtained from treatment-naive subject. three...
Dengue fever is an endemic virus-borne disease that causes many severe ailments, including dengue hemorrhagic and shock syndrome. NS2B-NS3 protease present in all four strains of the virus. a non-structural protein performs three distinct functions: activity, helicase nucleoside triphosphatase activity. pro-complex plays crucial role viral replication, NS2B interacts with NS3 at flat active site amino acid N-terminal region. acts as cofactor for protease. In current study, conserved residues...
Serine protease cleaved-complement component 4 (C4) at sessile loop, which is significant for completion of lectin and classical complement pathways the time infections. The co-crystalized structure C4 with Mannose-binding protein-associated serine 2 (MASP2) provided structural functional aspects its interaction underlined activation by MASP2. same study also revealed significance control protein (CCP) domain through mutational study, where mutated CCP led to inhibition activation. However,...