A5009772102- Helicobacter pylori-related gastroenterology studies
- Congenital gastrointestinal and neural anomalies
- Gastrointestinal motility and disorders
- Monoclonal and Polyclonal Antibodies Research
- Cytokine Signaling Pathways and Interactions
- Psoriasis: Treatment and Pathogenesis
King's College London
2023
Vall d'Hebron Institut de Recerca
2023
Universitat Autònoma de Barcelona
2023
Irritable bowel syndrome (IBS) is a chronic disorder of gut-brain interaction frequently accompanied by mental conditions, including depression and anxiety. Despite showing substantial heritability being partly determined genetic component, the underpinnings explaining high rates comorbidity remain largely unclear there are no conclusive data on temporal relationship between them. Exploring overlapping architecture IBS conditions may help to identify novel loci biological mechanisms...
Generalized pustular psoriasis (GPP) is a potentially life-threatening skin disease, associated with IL36RN mutations. encodes the interleukin (IL)-36 receptor antagonist (IL-36Ra), protein that downregulates activity of IL-36 cytokines by blocking their (IL-36R). While GPP can be treated IL-36R inhibitors, structural underpinnings IL-36Ra/IL-36R interaction remain poorly understood. Here, we sought to address this question systematically investigating effects mutations.We experimentally...
ABSTRACT Background Irritable bowel syndrome (IBS) is a chronic disorder of gut-brain interaction frequently accompanied by mental conditions, including depression and anxiety. Despite showing substantial heritability being partly determined genetic component, the underpinnings explaining high rates comorbidity remain largely unclear there are no conclusive data on temporal relationship between them. Exploring overlapping architecture IBS conditions may help to identify novel loci biological...