A5029100778- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- Chemical Synthesis and Analysis
- Protein Structure and Dynamics
- Biochemical effects in animals
- Stress Responses and Cortisol
- Diet, Metabolism, and Disease
- Cannabis and Cannabinoid Research
- Computational Drug Discovery Methods
- Alzheimer's disease research and treatments
- Menopause: Health Impacts and Treatments
- Estrogen and related hormone effects
- Hormonal Regulation and Hypertension
- Phytoestrogen effects and research
- Neuroendocrine regulation and behavior
- GABA and Rice Research
- Neuroscience and Neuropharmacology Research
- Biochemical Analysis and Sensing Techniques
- GaN-based semiconductor devices and materials
- Molecular spectroscopy and chirality
- Amino Acid Enzymes and Metabolism
- Antimicrobial Peptides and Activities
- Advanced NMR Techniques and Applications
- Mass Spectrometry Techniques and Applications
- Neurobiology and Insect Physiology Research
Jawaharlal Nehru University
2009-2019
All India Institute of Medical Sciences
2009
Washington University in St. Louis
2007
UCLouvain Saint-Louis Brussels
1999
Saint Louis University
1999
University of Missouri–St. Louis
1999
Jawaharlal Nehru Centre for Advanced Scientific Research
1996
A CB1 cannabinoid receptor peptide fragment from the C-terminal juxtamembrane region autonomously inhibits adenylyl cyclase activity in a neuroblastoma membrane preparation. The antagonist, SR141716A, failed to block response. was able evoke response membranes Chinese hamster ovary (CHO) cells that do not express receptor. These studies are consistent with direct activation of Gi by peptide. To test importance BXBXXB sequence, Lys403 acetylated, resulting having similar affinity but reduced...
The tachykinin receptor NK3 is a member of the rhodopsin family G-protein coupled receptors. has been regarded as an important drug target due to diverse physiological functions and its possible role in pathophysiology psychiatric disorders, including schizophrenia. primarily activated by peptide hormone neurokinin B (NKB) which most potent natural agonist for receptor. NKB reported play vital normal human reproduction pathway potentially life threatening diseases such pre-eclampsia...
Abstract Both the aqueous and lipid-induced structure of a representative widely studied tachykinin, substance P, has been investigated by two-dimensional proton nuclear magnetic resonance (2D 'H-NMR) spectroscopy distance geometry calculations. Unambiguous NMR assignments protons have made with aid correlation (COSY TOCSY) experiments Overhauser enhancement (ROESY NOESY) experiments. The data obtained were utilized in algorithm to generate family structures which further refined using...
Abstract Neurokinin B (NKB), a decapeptide of mammalian origin exhibits variety biological activities such as regulatory functions in reproduction, pre-eclampsia and neuroprotection Alzheimer's disease. In order to gain insight into structure-function relationship, three- dimensional structure NKB has been investigated using CD spectropolarimetry two-dimensional proton nuclear magnetic resonance (2D 1H-NMR) spectroscopy aqueous membrane mimetic solvents. Unambiguous NMR assignments...
Abstract Both the aqueous and lipid-induced structure of Kassinin, a dodecapeptide amphibian origin, has been studied by two-dimensional proton nuclear magnetic resonance (2D 1H-NMR) spectroscopy distance geometry calculations. Unambiguous NMR assignments protons have made with aid correlation (DQF-COSY TOCSY) experiments Overhauser effect (NOESY ROESY) experiments. The constraints obtained from data utilized in algorithm to generate family structures, which refined using restrained energy...
Abstract A peptide comprising the juxtamembrane C‐terminal intracellular loop 4 (IL4) of CB 1 cannabinoid receptor possesses three serine residues (Ser402, Ser411, and Ser415). We report effect Ser phosphorylation on IL4 conformation cellular signaling functions using nuclear magnetic resonance spectroscopy, circular dichroism (CD), G protein activation, cyclic adenosine monophosphate (cAMP) production. Phosphorylation at induced helical structure in different environments. Helical content...
ABSTRACT PPT‐C encoded hemokinin‐1(hHK‐1) of Homo sapiens (TGKASQFFGLM) is a structurally distinct neuropeptide among the tachykinin family that participate in NK‐1 receptor downstream signaling processes. Subsequently, signal transduction leads to execution various effector functions which includes aging, immunological, and central nervous system (CNS) regulatory actions. However conformational pattern ligand binding unclear. The three‐dimensional structure hemokinin‐1 aqueous micellar...
The neurokinin-2 receptor is a member of the rhodopsin family G-protein coupled receptors, which represents one most relevant target families in small-molecule drug design. NK-2 receptors have been implicated playing pathophysiological role asthma. Activation by its endogenous peptide agonist, tachykinins, associated with diverse biological responses like bronchoconstriction, vasodepression, and regulation endocrine functions. Agonist binding to crucial event initiating signaling, therefore...
Neuropeptide K (NPK), an N-terminally extended form of neurokinin A (NKA), represents the most potent and longest lasting vasodepressor cardiomodulatory tachykinin reported thus far. NPK has been shown to have high selectivity for NK2 receptor. Because micelle-associated structure may be relevant NPK−receptor interaction, three-dimensional in aqueous micellar environments studied by two-dimensional proton nuclear magnetic resonance (2D 1H NMR spectroscopy) distance geometry calculations....