A5103145494- Axon Guidance and Neuronal Signaling
- Lymphatic System and Diseases
- Congenital heart defects research
- Angiogenesis and VEGF in Cancer
- Zebrafish Biomedical Research Applications
- Histone Deacetylase Inhibitors Research
- Vestibular and auditory disorders
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Sleep and Wakefulness Research
- Apelin-related biomedical research
Cincinnati Children's Hospital Medical Center
2011-2021
University of Cincinnati
2013
NeuroDevelopment Center
2013
Columbia University
2004
Howard Hughes Medical Institute
2004
Johns Hopkins University
2004
Institut de Biologie du Développement Marseille
2004
Inserm
2004
The development of a patterned vasculature is essential for normal organogenesis. We found that signaling by semaphorin 3E (Sema3E) and its receptor plexin-D1 controls endothelial cell positioning the patterning developing in mouse. Sema3E highly expressed somites, where it acts as repulsive cue plexin-D1–expressing cells adjacent intersomitic vessels. Sema3E–plexin-D1 did not require neuropilins, which were previously presumed to be obligate Sema3 coreceptors. Moreover, genetic ablation or...
Significance The basal ganglia process cortical information that controls purposeful movements and appropriate behavior via the striatopallidal striatonigral pathways. Despite their importance, little is known about developmental mechanisms control formation of these We show here telencephalic progenitors expressing transcription factor Islet1 give rise to neurons this required for normal development pathway. Moreover, mouse mutants exhibit hyperactivity a paradoxical response...
The vertebrate circulatory system is composed of closely related blood and lymphatic vessels. It has been shown that vascular patterning regulated by vessels during development, but its molecular mechanisms have not fully elucidated. Here, we show the artery-derived ligand semaphorin 3G (Sema3G) endothelial cell receptor PlexinD1 play a role in patterning. In mouse embryonic back skin, genetic inactivation Sema3G or results abnormal artery-lymph alignment reduced branching. Conditional...
Blood and lymphatic vessels surrounding the heart develop through orchestrated processes from cells of different origins. In particular, around outflow tract which constitute a primordial transient vasculature, referred to as aortic subepicardial vessels, are crucial for establishment coronary artery stems cardiac vessels. Here, we revealed that epicardium pericardium-derived Semaphorin 3E (Sema3E) its receptor, PlexinD1, play role in development stem, well vitro analyses demonstrated Sema3E...
The tail movement is critical for maintaining balance during locomotion in many animal species, yet its underlying neuro-muscular control remains poorly understood. In this study we investigated what are the neuronal substrates responsible mice. Using high-resolution microCT scans and retrograde labeling, lay out organization of identified distinct pools motoneurons spinal cord that innervate proximal distal muscles. We further show vestibular nucleus (SpVN) brainstem sends direct...