A5050021797- Gold and Silver Nanoparticles Synthesis and Applications
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- 3D Printing in Biomedical Research
- Immune Response and Inflammation
- Nanoplatforms for cancer theranostics
- Spectroscopy Techniques in Biomedical and Chemical Research
- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Nanoparticles: synthesis and applications
- Photoacoustic and Ultrasonic Imaging
- Cellular Mechanics and Interactions
- Monoclonal and Polyclonal Antibodies Research
- Quantum Dots Synthesis And Properties
- Spectroscopy and Quantum Chemical Studies
- Cancer Cells and Metastasis
- Nanocluster Synthesis and Applications
- Pickering emulsions and particle stabilization
- Advanced Drug Delivery Systems
- Microfluidic and Bio-sensing Technologies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Mass Spectrometry Techniques and Applications
- Characterization and Applications of Magnetic Nanoparticles
- Additive Manufacturing and 3D Printing Technologies
CIC biomaGUNE
2016-2025
Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine
2016-2025
Boeing (Spain)
2025
Digital Research Alliance of Canada
2025
Centro de Investigación Biomédica en Red
2020-2024
Harvard University
2019
Ayuntamiento de San Sebastián
2016-2017
Aston University
2009-2012
Statens Serum Institut
2010
Materials scientists have performed exceptional accomplishments in the design of various types materials that can be directly used for biomedical research. In particular, nanomaterials (including plasmonic nanoparticles) become forefront scaffolds designing bioactive materials. The application such biomedicine however requires a directed providing actuation and stability particularly complex environment as living organisms. Enhanced diagnostic tools diseases cancer HIV are pursued, this...
Labeled nanoparticles have attracted much interest toward applications in bioimaging and diagnostics. In particular, surface enhanced Raman scattering (SERS) nanotags been demonstrated to be excellent candidates for multiplexed imaging biological detection. We propose an alternative, effective method easily prepare gold nanostars exhibiting plasmon bands the near-infrared range, encoded with reporter molecules, concomitantly acting as capping agents which are then protected amphiphilic...
Despite recent advances in the development of scaffold-based three-dimensional (3D) cell models, challenges persist imaging and monitoring behavior within these complex structures due to their heterogeneous distribution geometries. Incorporating sensors into 3D scaffolds provides a potential solution for real-time,
Janus Au–Fe<sub>3</sub>O<sub>4</sub> star-sphere nanoparticles show their high versatility as contrast agents in multimodal imaging.
Poly(ethylene glycol) (PEG) has become the gold standard for stabilization of plasmonic nanoparticles (NPs) in biofluids, because it prevents aggregation while minimizing unspecific interactions with proteins. Application Au NPs biological environments requires use ligands that can target selected receptors, even presence protein-rich media. We demonstrate here stabilizing effect low-molecular-weight glycans on both spherical and rod-like under physiological conditions, as bench-marked...
The immunostimulatory capacities of cationic liposomes are well-documented and attributed both to inherent immunogenicity the lipid more physical such as formation antigen depots delivery. Very few studies have however been conducted comparing different lipids. In present study we therefore chose investigate three most well-known liposome-forming lipids potential adjuvants for protein subunit vaccines. ability 3β-[N-(N',N'-dimethylaminoethane)carbomyl] cholesterol (DC-Chol),...
Hybrid colloidal nanocomposites comprising polystyrene beads and plasmonic gold nanostars are reported as multifunctional optical nanoprobes. Such self-assembled structures excellent Raman enhancers for bioapplications they feature plasmon modes in the near-infrared "first biological transparency window". In this proof of concept study, we used 4-mercaptobenzoic acid a Raman-active molecule to optimize density on beads, improving SERS performance thereby allowing vitro cell culture imaging....
We describe an approach to regulate the cellular uptake of small gold nanoparticles using supramolecular chemistry. The strategy relies on functionalization AuNPs with negatively charged pyranines, which largely hamper their penetration in cells. Cellular can be activated situ through addition cationic covalent cages that specifically recognize fluorescent pyranine dyes and counterbalance negative charges. high selectivity reversibility host–guest recognition activates uptake, even...
Abstract Methods to image complex 3D cell cultures are limited by issues such as fluorophore photobleaching and decomposition, poor excitation light penetration, lack of complementary techniques verify the structure. Although it remains insufficiently demonstrated, surface‐enhanced Raman scattering (SERS) imaging is a promising tool for characterization biological systems. To this aim, controllable culture model which spans nearly 1 cm 2 in surface footprint designed. This structure composed...
When nanoparticles (NPs) are exposed to biological media, proteins adsorbed, forming a so-called protein corona (PC). This cloud of aggregates hampers the targeting and transport capabilities NPs, thereby compromising their biomedical applications. Therefore, there is high interest in development technologies that allow control over PC formation, as this would provide handle manipulate NPs fluids. We present strategy enables reversible disruption using external stimuli, allowing precise...
With the ever-increasing use of 3D cell models toward studying bio-nano interactions and offering alternatives to traditional 2D in vitro vivo experiments, methods image biological tissue real time with high spatial resolution have become a must. A suitable technique therefore is surface-enhanced Raman scattering (SERS)-based microscopy, which additionally features reduced photocytotoxicity improved light penetration. However, optimization imaging postprocessing parameters still required....
Gold–silica self-assembled nanostructures are reported as multiplex surface enhanced Raman scattering (SERS) tags for bioimaging applications. These hybrid colloidal particles were obtained by heteroassembly of Au–SiO2 Janus with smaller Au spheres and two Raman-active molecules that can be independently imaged varying the wavelength excitation laser. The structure not only directs assembly but also provides physical separation stability thereby facilitating complete silica encapsulation....
Abstract Methods for efficient detachment of cells avoiding damage are required in tissue engineering and regenerative medicine. We introduce a bottom–up approach to build plasmonic substrates using micellar block copolymer nanolithography generate 2D array Au seeds, followed by chemical growth leading anisotropic nanoparticles. The resulting show broad plasmon band covering wide part the visible near‐infrared (NIR) spectral ranges. Both human murine were successfully grown on substrates. A...
Preferential uptake by cancer cells of PEG-inulin coated gold nanoparticles loaded with the drug doxorubicin.