A5028442233- Zebrafish Biomedical Research Applications
- Aquaculture disease management and microbiota
- Essential Oils and Antimicrobial Activity
- Ethnobotanical and Medicinal Plants Studies
- Aquaculture Nutrition and Growth
- Hibiscus Plant Research Studies
- Herbal Medicine Research Studies
- Amphibian and Reptile Biology
- Flavonoids in Medical Research
- Cholesterol and Lipid Metabolism
- Antioxidant Activity and Oxidative Stress
- Phytochemistry and Bioactivity Studies
- Natural Antidiabetic Agents Studies
- Plant-derived Lignans Synthesis and Bioactivity
- Traditional and Medicinal Uses of Annonaceae
- Biological and pharmacological studies of plants
- Computational Drug Discovery Methods
- Psidium guajava Extracts and Applications
- Phytochemistry Medicinal Plant Applications
- Animal testing and alternatives
- Bioactive natural compounds
- Saffron Plant Research Studies
- Photochromic and Fluorescence Chemistry
- Estrogen and related hormone effects
- Apelin-related biomedical research
Universidade Federal do Amapá
2017-2024
Universidade de Brasília
2020
Universidade Federal do Pará
2017
The plant species Acmella oleracea L. is used in the north of Brazil for treatment a range illnesses, such as tuberculosis, flu, cough, and rheumatism an anti-inflammatory agent; besides, hydroethanolic formulations with this are popularly female aphrodisiac agent. However, currently, there no studies performed evaluating its effect on embryonic development. Hence, research aimed to evaluate effects extract A. (EHFAo) reproductive performance (parental) development (F1 generation) zebrafish,...
The plant species Libidibia ferrea (Mart. ex Tul.) LP Queiroz var. basionym of Caesalpinia is used in various regions Brazil folk medicine the treatment several health problems, especially acute and chronic inflammatory processes. Most preparations employed are alcoholic. Therefore, this study aimed to evaluate toxicity hydroethanolic extract fruits (EHEFLf) zebrafish, emphasizing possible changes organic-cellular level gills, liver, kidneys, intestine on embryos. result obtained by LC-M/MS...
Hydroethanolic preparations of the botanical species Acmella oleracea L. are used in north Brazil for treatment various diseases. However, few studies have been conducted to evaluate toxicity this species. The objective study was acute hydroethanolic extract A. (EHFAo) flowers zebrafish by immersion and oral administration. analyzed ultra-performance liquid chromatography-mass spectrometry (UPLC-MS). EHFAo administered orally (44.457, 88.915, 199.94, 281.83, 448.81 mg/kg) (250, 300, 350,...
Endopleura uchi (Huber) Cuatrec is a plant species from the Brazilian Amazon. The barks of this tree are used in folk medicine - mainly as decoction for dyslipidemia, uterine infection, fibroids, polycystic ovary, menstrual disorders, contraceptive and abortive agent, among others. However, data available about its developmental toxicity still insufficient.This study aimed to evaluate reproductive teratogenic effects embryos zebrafish treated with hydroethanolic extract (EEu).Both sexes...
Hancornia speciosa Gomes is a tree native to Brazil and has therapeutic potential for several diseases. Ethnopharmacological surveys have reported that the plant used as hypoglycemic agent lose weight. This study aimed evaluate effects of aqueous extract from H. latex (LxHs) in zebrafish model diabetes. The was evaluated through high-performance thin-layer chromatography (HTPLC), nuclear magnetic resonance (NMR), Fourier-transform infrared spectroscopy (FT-IR). We then tested treatments with...
Dyslipidemia presents high levels of serum cholesterol, being characterized as a risk factor for cardiovascular diseases, especially the development atherosclerosis. E. oleracea (OFEO), A. esculentus (OFAE), B. orellana (OFBO) and granulated (CHR) oils are rich in bioactive compounds with potential to treat changes lipid metabolism. This study investigated effects treatments from esculentus, oleracea, granules (Chronic SM®) on saturated fat-induced dyslipidemia Cocos nucifera L. The...
Dyslipidemia presents high levels of serum cholesterol and is characterized as a risk factor for cardiovascular diseases, especially the development atherosclerosis.
The absence of effective vaccines against malaria and the difficulties associated with controlling mosquito vectors have left chemotherapy as primary control measure malaria. However, emergence spread parasite resistance to conventional antimalarial drugs result in a worrisome scenario making search for new priority. In present study, activities nine neolignan derivatives were evaluated follows: (i) blood forms chloroquine‐resistant Plasmodium falciparum (clone W2), using tritiated...
The zebrafish is a popular organism to test the toxicity of compounds. Here, we evaluate acute and reproductive Ormona SI® (OSI) RC® (ORC), two herbal products developed for menopausal women with tocotrienols, geranylgeraniol, isoflavones, anthocyanins. was evaluated by behavioral alterations, lethality, tissue changes (intestine, liver, kidney) after oral treatment high product doses (500, 1000, 2000 mg/kg). 21 days OSI ORC at 200 mg/kg. Our results show that LD50 could not be assessed due...
The species Trattinnickia rhoifolia Willd, (T. rhoifolia), which belongs to the Burseraceae family, is widely used in ethnopharmacological cultural practices by traditional Amazonian people for anti-inflammatory purposes, sometimes as their only therapeutic resource. Although it teas, infusions, macerations and food, still unexplored regard its pharmacophoric potential chemical profile. Therefore, aim of this study was conduct a phytochemical characterization hydroethanolic extract T. leaves...
Context The botanical species Bauhinia guianensis Aublet (Leguminosae-Cercidoideae) is traditionally used in the Amazon for medicinal purposes.
Eleutherine bulbosa (Miller) Urb, popularly known as "marupa-zinho", is frequently used in traditional medicine for treating various diseases, including hypertension, ulcers, constipation, and intestinal infection. However, there little scientific knowledge available regarding the pharmacological effects of this species. Thus vivo silico phytochemical studies are required to establish whether plant has these effects. Further tests were necessary evaluate activity compounds found plant,...
The leaves and stems of Bauhinia guianensis Aubl. are used in traditional Amazonian phytotherapy for the treatment pain inflammation. This study investigates anti-inflammatory antinociceptive effects hydroethanolic extracts from B. (HELBg HESBg, respectively) vivo models inflammation hyperalgesia. Danio rerio experimental animals were submitted to acute test, induced by intraperitoneal (ip.) administration carrageenan 20 μg / animal (abdominal edema), groups previously treated orally...
The leaves and stems of Bauhinia guianensis Aubl. are used in traditional Amazonian phytotherapy for the treatment pain inflammation. This study investigates anti-inflammatory antinociceptive effects hydroethanolic extracts from B. (HELBg HESBg, respectively) vivo models inflammation hyperalgesia. Danio rerio experimental animals were submitted to acute test, induced by intraperitoneal (ip.) administration carrageenan 20 μg / animal (abdominal edema), groups previously treated orally with...
Abstract Baicalein (BA) is a flavonoid with wide-ranging pharmacological activity. However, its biological evaluation hampered by low solubility in aqueous medium, making forms of incorporation that improve necessary. In the present study, BA was combined solution silk fibroin protein (SF), biomaterial used as drug carrier, to evaluate anti-inflammatory potential this combination, vivo, an experimental model, zebrafish ( Danio rerio ). Baicalein-Silk (BASF) improved DPPH...
Abstract Bixa orellana L. is a plant popularly known as “ucurum”, “annatto”, and “achiote”. It native to South America, its seeds are an abundant source of geranylgeraniol tocotrienols. Nanoencapsulation valuable technique that can decrease the drug needed achieve effect, decreasing potential toxicity side effects. This study aimed evaluate acute intramuscular application nanodispersion containing standardized extract (Chronic®) from (NBO) in Wistar rats. The chemical evaluation showed...