A5017464514- Oxidative Organic Chemistry Reactions
- Andrographolide Research and Applications
- Metal-Catalyzed Oxygenation Mechanisms
- Molecular spectroscopy and chirality
- Traditional and Medicinal Uses of Annonaceae
- Synthesis and biological activity
- Cancer Treatment and Pharmacology
- Crystal structures of chemical compounds
- Natural product bioactivities and synthesis
- Plant-based Medicinal Research
- Phytochemicals and Antioxidant Activities
- Radical Photochemical Reactions
- Porphyrin and Phthalocyanine Chemistry
- Genomics, phytochemicals, and oxidative stress
- Metal complexes synthesis and properties
- Inorganic and Organometallic Chemistry
- Fungal Plant Pathogen Control
- TGF-β signaling in diseases
- Cell death mechanisms and regulation
- Protease and Inhibitor Mechanisms
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Developmental Biology and Gene Regulation
- African Botany and Ecology Studies
- Peptidase Inhibition and Analysis
- Berberine and alkaloids research
Stony Brook University
2025
Hospital for Special Surgery
2023
Advanced Centre for Treatment, Research and Education in Cancer
2021
Tata Memorial Hospital
2021
University of Calicut
2012-2017
University of Montana
2007
Biliverdin IXβ reductase (BLVRB) is an NADPH-dependent enzyme previously implicated in a redox-regulated mechanism of thrombopoiesis distinct from the thrombopoietin (TPO)/c-MPL axis. Here, we apply computational modeling to inform molecule design, followed by de novo syntheses and screening unique small molecules retaining capacity for selective BLVRB inhibition as novel platelet-enhancing strategy. Two classes are identified, NMR spectroscopy co-crystallization studies confirm binding...
We describe the presence and characteristics of two self-splicing group I introns in sole 23S rRNA gene Coxiella burnetii. The introns, Cbu.L1917 Cbu.L1951, are inserted at sites 1917 1951 (Escherichia coli numbering), respectively, C. Both were found to be vivo vitro even though terminal nucleotide is adenine not canonical conserved guanine, termed OmegaG, Cbu.L1951 all other described date. Predicted secondary structures for both constructed revealed that IB2 IA3 respectively. analyzed...
This review explores the mechanisms of cytotoxic and anti‑inflammatory properties andrographolide derivatives in various cell lines. In vitro vivo studies that shed light on molecular cytotoxicity property its are reviewed here. Cytotoxic effect cancer lines mainly due to induction reactive oxygen species, activation c‑Jun N‑terminal kinase, inhibition autophagy, apoptosis. Anti‑inflammatory is predominantly covalent nuclear factor kappa B transcription thereby targets genes such as tumor...
Abstract The transition from notochord to vertebral column is a crucial milestone in chordate evolution and prenatal development of all vertebrates. As ossification the bodies proceeds, involutions residual cells into intervertebral discs form nuclei pulposi , shock-absorbing structures that confer flexibility spine. Numerous studies have outlined developmental evolutionary relationship between . However, knowledge similarities differences genetic repertoires these two remains limited, also...
To investigate the effect of DMSO on cisplatin induced cytotoxicity (invitro) against K562 (Human mylogenous leukemia) cell line and to study cisplatin-DMSO adduct formation using UV-spectrophotometer.Effect was studied in (Chronic by MTT assay. Cisplatin-DMSO continuously monitoring increase absorption peaks for 30 minutes UV-spectrophotometer.0.1-0.3% markedly reduced cytotoxic activity cells. detected UV-spectrophotometer. Continuous UV absorbance between 250nm-290nm observed when...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions of exo- and endo-8-carbenatricyclo[3.2.1.02,4]octanePeter K. Freeman, R. S. Raghavan, Donald G. KuperCite this: J. Am. Chem. Soc. 1971, 93, 20, 5288–5290Publication Date (Print):October 1, 1971Publication History Published online1 May 2002Published inissue 1 October 1971https://pubs.acs.org/doi/10.1021/ja00749a071https://doi.org/10.1021/ja00749a071research-articleACS PublicationsRequest reuse permissionsArticle...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRadical chlorination of exo- and endo-tricyclo[3.2.1.02,4]octane exo,exo- exo,endo-tetracyclo[3.3.1.02,4.06,8]nonane with tert-butyl hypochloritePeter K. Freeman, Timothy D. Ziebarth, R. S. RaghavanCite this: J. Am. Chem. Soc. 1975, 97, 7, 1875–1882Publication Date (Print):April 1, 1975Publication History Published online1 May 2002Published inissue 1 April...
Tetracycline and glutathione inhibited the protease activities of matrix metalloproteinase-2 metalloproteinase-9 expressed by mouse fibrosarcoma cells (L929) Dalton lymphoma cells, respectively. The inhibitory activity tetracycline may be due to its ability chelate metal ions such as calcium zinc. Gelatin-zymography technique was used demonstrate both glutathione. intensity bands corresponding metalloproteinase in zymography gel reduced presence 50–100 μ g/mL tetracycline. 10–100 medium...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions of exo- and endo-8-carbenatricyclo[3.2.1.02,4]octanePeter K. Freeman, Thomas A. Hardy, R. S. Raghavan, Donald G. KuperCite this: J. Org. Chem. 1977, 42, 24, 3882–3892Publication Date (Print):November 1, 1977Publication History Published online1 May 2002Published inissue 1 November 1977https://pubs.acs.org/doi/10.1021/jo00444a019https://doi.org/10.1021/jo00444a019research-articleACS PublicationsRequest reuse permissionsArticle...
Andrographolide is a potent anticancer and anti-inflammatory agent isolated from the plant Andrographis paniculata. It found to be cytotoxic against various cancer cell lines (in vitro) also reported act as an by interfering with NF-κB protein. induced higher percentage of apoptosis in glutathione-depleted lymphoma lines. was form dehydrated adduct reduced glutathione at 50° C. On basis these observations, docking analysis andrographolide its target protein (NF-κB/p50) proposed anti-target...
Objective: To evaluate the anticancer and antioxidant activity of medicinal plant Clidemia hirta extracted in different solvents.Methods: Crude extracts were prepared from leaves using ethanol, petroleum ether chloroform solvents. Anticancer activities properties assayed standard yellow dye 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) 1, 1-diphenyl-2-picryl hydrazyl (DPPH) free radical scavenging assay respectively.Results: We found that ethanol extract had higher...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRadical chlorination of exo- and endo-tricyclo[3.2.1.02,4]octane with tert-butyl hypochloritePeter K. Freeman, R. S. Raghavan, Gary L. FenwickCite this: J. Am. Chem. Soc. 1972, 94, 14, 5101–5103Publication Date (Print):July 1, 1972Publication History Published online1 May 2002Published inissue 1 July 1972https://doi.org/10.1021/ja00769a063RIGHTS & PERMISSIONSArticle Views44Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the...
The present study was performed to evaluate the antiproliferative property of (Z)-ethylidene-4, 6-dimethoxycoumaran-3-one (EDC), isolated from Pogostemon quadrifolius (Benth.)leaf against chronic myelogenous leukemia cell line (K-562).The purity and identity compound were confirmed by HPLC ESI-MS analysis.Cell viability assay (MTT) effect EDC on K-562 line.The result showed that inhibited proliferation with an IC 50 7.77±0.21µg mLG 1 (35.3 µM).Further DNA fragmentation identify mode action...
The study was conducted to evaluate the DPPH scavenging property of leaf extracts plant P. quadrifolius (Benth.).In this study, leaves were solvent extracted by soxhlet method using petroleum ether, chloroform and methanol sequentially.The then analyzed for properties.Among three used, only extract has exhibited property.The results showed that (Benth.)leaf exhibit with IC 50 14.5±1.05µg mLG 1 .The phytochemical analysis indicated is a rich source phenolic compounds may be reason radical extract.
Abstract Bei der Zersetzung des aus (Ia) erhaltenen Tosylhydrazons (Ib) entstehen die bicyclischen Olefine (II) und (III).
The aim of the study was to isolate and identify major cytotoxic principle from plant leaves Pogostemon quadrifolius (Benth.) evaluate its antiproliferative potential against human cancer cells. Plant were extracted sequentially with a soxhlet apparatus, using petroleum ether, chloroform methanol solvents. Petroleum ether extracts exhibited properties Caco-2, HeLa, THP-1, MCF-7 Jurkat E6-1cancer cell lines tested, but failed exhibit such activity. isolated help bioassay guided column...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFree-radical addition of tert-butyl hypochlorite to some bridged polycyclic olefinsPeter K. Freeman and R. S. RaghavanCite this: J. Org. Chem. 1972, 37, 23, 3670–3675Publication Date (Print):November 1, 1972Publication History Published online1 May 2002Published inissue 1 November 1972https://pubs.acs.org/doi/10.1021/jo00796a022https://doi.org/10.1021/jo00796a022research-articleACS PublicationsRequest reuse permissionsArticle...
Abstract Die thermische Zersetzung des Tosylhydrazons (I) in Bis‐(2‐äthoxy‐äthyl)‐ äther/Na‐methylat liefert ein 65 : 35‐Gemisch Diens (II) und zweier isomerer Diene (III) (20% Gesamtausbeute).
Abstract Während die Bestrahlung des exo‐Tricyclooctans (I) in Gegenwart von tert.‐Butylhypochlorit Tetrachlorkohlenstoff als Lösungsmittel Monochloride (II)‐(IV) im Verhältnis 67: 12: 17 liefert, entstehen unter gleichen Bedingungen aus den endo‐Isomeren (V) (VI) und (VII) zwei nicht charakterisierbare 66:27: 5:2 Hauptprodukte.
Abstract Bei der Bestrahlung einer Mischung von endo‐Tricycloocten (I) oder dem exo‐ Tricycloocten (VI) und tert.‐Butylhypochlorit (II) entstehen jeweils die isomeren Addukte (III) (IV) bzw. (VII) (VIII), mit Tributylzinnhydrid zu den tert.‐Butyläthern (V) (IX) dechloriert werden.