Abstract During the coronavirus disease 2019 (COVID-19) pandemic, a new phenomenon manifesting as multisystem inflammatory syndrome in children (MIS-C) which has similar clinical presentation to Kawasaki disease, toxic shock and severe sepsis emerged. Although number of MIS-C reports is increasing, rare Asia still available. To our knowledge, this study largest series published cases Iran. We performed retrospective all patients with case definition for admitted three paediatric hospitals...

Abstract Background Bloodstream infections (BSI) are the major cause of morbidity and mortality in children developing countries. The purpose current study was to establish antimicrobial susceptibility pattern bacterial isolates from bloodstream at Children’s Medical Center Hospital (CMC), Tehran, Iran. Methods We retrospectively recorded all positive blood cultures among admitted CMC, during 5 years. Specimen culture, identification, testing were performed according standard laboratory...

Background: Despite the worldwide spread of coronavirus disease 2019 (COVID-19), epidemiological and clinical patterns COVID-19 infection remain largely unclear, particularly among children. In this study, we explored characteristics, patterns, laboratory imaging findings pediatric patients with COVID-19. Materials Methods: From March 7 to 30, 2020, there were a total 35 who had confirmed by virus nucleic acid test (RT-PCR) assay throat swab samples or typical chest CT manifestation...

<b><i>Background:</i></b> Although the pathophysiology of coronavirus disease 2019 (COVID-19) is not clearly defined, among proposed mechanisms, immune system dysfunction more likely than others. The aim this study was to clarify characteristics and clinical significance dynamic changes lymphocyte subsets in course COVID-19. <b><i>Methods:</i></b> In prospective study, levels peripheral including CD4<sup>+</sup>,...

Although vaccines would be the ideal tool for control, prevention, elimination, and eradication of many infectious diseases, developing parasites such as malaria vaccine is very complex. The most advanced candidate RTS,S, a pre-erythrocytic vaccine, has been recommended licensure by EMEA. results this phase III trial suggest that relatively little efficacy, apparently will not meet goal itself. Since there are candidates in pipeline 1 being evaluated trials, further study on using...

Varicella, commonly known as chickenpox, is typically considered a mild childhood illness but can lead to severe complications necessitating hospitalization. In Iran, the varicella-zoster vaccine not currently included in routine immunization schedule. This case series study aimed characterize skin of varicella children admitted an Iranian referral hospital. reviewed 17 pediatric cases hospitalized for and demographics data, clinical presentation, outcomes were collected. Between December...

Bloodstream infections (BSI) are a serious cause of morbidity and mortality worldwide. Emerging antimicrobial drug resistance among bacterial pathogens causing BSI can limit therapeutic options complicate patient management.To encourage the prudent use appropriate antibiotics in our pediatric population at Children's Medical Center Hospital, Tehran, Iran, we studied frequency antibiogram patterns blood culture isolates from January 2001 to December 2005.Of 25,223 cultures examined, 2,581...

Although several invasive and noninvasive tests have been developed for the diagnosis of Helicobacter pylori infection, all their limitations. We conducted a study to investigate compare suitability rapid urease test (RUT), serology, histopathology stool antigen with polymerase chain reaction (PCR) detection H. pylori, correlate diagnostic methods PCR. Eighty nine patients (61 adults, 28 children) referred Firoozgar Hospital Children Medical Center upper gastrointestinal endoscopy entered...

The clinical importance of Staphylococcus aureus (S. aureus) is attributed to notable virulence factors, surface proteins, toxins, and enzymes as well the rapid development drug resistance. aim this study was compare occurrence factors produced by S. strains isolated from children in an Iranian referral children's hospital.The presence genes encoding for enterotoxins A (sea), B (seb), C (sec), D (sed), TSST-1 (tsst), exfoliative toxin (eta), (etb) were detected Multiplex polymerase chain...

After more than 20 years of research, there is a little information about the detailed routes Helicobacter pylori transmission. The aim this study was to explore intrafamilial transmission H. in children who had indication for upper gastrointestinal endoscopy and their parents.Children (aged up 15 years) were studied during September 2012 October 2013. parents those with positive urea breath test results asked provide faecal blood samples after giving informed consent. Non-invasive tests...

Typical presentations of Coronavirus Disease 2019 (Covid‐19) including respiratory symptoms (cough, distress and hypoxia), fever dyspnoea are considered main in adults, but atypical presentation children could be a diagnostic challenge. We report three whose initial was gastrointestinal, whom Covid‐19 infection found, concluding that cases acute appendicitis, mesenteric adenitis flank tenderness may mask an with this virus, should therefore investigated.

During the coronavirus disease 2019 (COVID-19) pandemic, Iran reported its first confirmed cases of syndrome 2 (SARS-CoV-2) infections on 19 February 2020 in Qom. Although numbers are increasing, no report about clinical manifestations, laboratory results, and imaging findings children infected with COVID-19 has been published. The aim this study was to evaluate epidemiological, clinical, radiological 24 who had proven SARS-CoV-2 infection performed chest computed tomographic (CT) Qom, Iran....

Coronavirus disease 2019 (COVID-19) is the current pandemic without any vaccine or efficient treatment to rescue patients. Underlying diseases predispose patients a more severe and higher mortality rate. However, little evidence exists about COVID-19 outcomes in pediatric population with congenital heart (CHD). Here, we report nine children concomitant CHD.Our study included CHD who were admitted Children Medical Center Hospital during March April 2020. The classified based on final outcome...

Abstract Since the initiation of COVID-19 vaccination effort, there has been widespread concern regarding vaccine efficacy and potential side effects. This study aimed to explore short-term effects four available vaccines (Sputnik V, Sinopharm, Oxford–AstraZeneca, Covaxin) among healthcare workers (HCWs) in Iran. The multicenter involved 1575 HCWs, with majority received Sputnik V (74.1%), followed by Covaxin (15.6%), Sinopharm (6.4%), Oxford-AstraZeneca (3.8%). prevalence at least one...

Emerging antimicrobial resistance rates and Extended-spectrum beta-lactamase producing Escherichia coli recovered from urinary tract infections (UTI) is an increasing problem in specific regions, limiting therapeutic options. One hundred E. isolates causing UTI patients with age 2 months to 12 years admitted at CMC the period of April 2009 March 2010 were tested for antibiotic susceptibility using disk diffusion method. Surprisingly high recorded against TMP/SMX (84%), cefalotin (66%),...

Abstract The coronavirus disease 2019 (COVID‐19) pandemic is an overwhelming crisis across the world. Human Coronavirus OC43 (HCoV‐OC43) a Betacoronavirus responsible mostly for mild respiratory symptoms. Since presentations of HCoV‐OC43 and severe acute syndrome 2 (SARS‐COV‐2) are believed to resemble lot, aim this study was evaluate frequency characteristics in current rate coinfection two viruses. One hundred seventeen patients referred Children's Medical Center, Tehran, Iran with...