A5005762117- Antimicrobial Resistance in Staphylococcus
- Bacterial biofilms and quorum sensing
- Bacterial Identification and Susceptibility Testing
- Salmonella and Campylobacter epidemiology
- Viral gastroenteritis research and epidemiology
- Vibrio bacteria research studies
- Metabolism and Genetic Disorders
- Plant Pathogenic Bacteria Studies
- Bacteriophages and microbial interactions
- Aquaculture disease management and microbiota
- Genomic variations and chromosomal abnormalities
- Genomics and Rare Diseases
UNSW Sydney
2020-2024
Salmonella enterica serovar Enteritidis is a major cause of foodborne infections and outbreaks in humans. Effective surveillance timely outbreak detection are essential for public health control. Multilevel genome typing (MGT) with multiple levels resolution has been previously demonstrated as promising tool this purpose. In study, we developed MGT nine S. characterised the genomic epidemiology detail. We examined 26 670 publicly available sequences from isolates spanning 101 years 86...
Abstract Background Newborn screening (NBS) is an effective public health intervention that reduces death and disability from treatable genetic diseases, but many conditions are not screened due to a lack of suitable assay. Whole genome whole exome sequencing can potentially expand NBS there remain technical challenges preventing their use in population NBS. We investigated if targeted gene (TGS) feasible methodology for expanding Methods constructed TGS panel 164 genes which screens broad...
Since 1817, cholera, caused by Vibrio cholerae, has been characterized seven distinct pandemics. The ongoing seventh pandemic (7P) began in 1961. In this study, we developed a Multilevel Genome Typing (MGT) tool for classifying the V. cholerae species with focus on 7P. MGT is based multilocus sequence typing (MLST), but concept expanded to include series of MLST schemes that compare population structure from broad fine resolutions. consists eight levels, lowest, MGT1, composed 7 loci and...
Abstract Staphylococcus aureus is a major source of both hospital and community acquired infections, the leading skin soft tissue infections worldwide. Advances in whole genome sequencing (WGS) technologies have recently generated large volumes S. WGS data. The timely classification data with genomic typing has potential to describe detailed epidemiology at small scales. In this study, multilevel (MGT) scheme comprised 8 levels multilocus sequence schemes increasing resolution was developed...
Staphylococcus aureus asymptomatically colonises 30 % of humans but can also cause a range diseases, which be fatal. In 2017 S . was associated with 20 000 deaths in the USA alone. Dividing S. isolates into smaller sub-groups reveal emergence distinct sub-populations varying potential to infections. Despite multiple molecular typing methods categorising such sub-groups, they do not take full advantage genome sequences when describing fundamental population structure species. this study, we...
Abstract Staphylococcus aureus asymptomatically colonises 30% of humans and in 2017 was associated with 20,000 deaths the USA alone. Dividing S. into smaller sub-groups can reveal emergence distinct sub-populations varying potential to cause infections. Despite multiple molecular typing methods categorising such sub-groups, they do not take full advantage WGS when describing fundamental population structure species. In this study, we developed Lineage Typing (SaLTy), which rapidly divides...
Abstract Salmonella enterica serovar Enteritidis is a major cause of foodborne infections and outbreaks in humans. Effective surveillance timely outbreak detection are essential for public health control. Multilevel genome typing (MGT) with multiple levels resolution has been previously demonstrated as promising tool this purpose. In study, we developed MGT nine S. characterised the genomic epidemiology detail. We examined 26,670 publicly available S . sequences from isolates spanning 101...