A5059063557- Eicosanoids and Hypertension Pharmacology
- Inflammatory mediators and NSAID effects
- Peroxisome Proliferator-Activated Receptors
- Metabolism and Genetic Disorders
- Epilepsy research and treatment
- Gout, Hyperuricemia, Uric Acid
- Nitric Oxide and Endothelin Effects
- Neuropeptides and Animal Physiology
- Advanced MRI Techniques and Applications
- Medical Imaging Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Fatty Acid Research and Health
- Diet and metabolism studies
- Adipokines, Inflammation, and Metabolic Diseases
- Helicobacter pylori-related gastroenterology studies
- Effects and risks of endocrine disrupting chemicals
- Neonatal and fetal brain pathology
- Estrogen and related hormone effects
- Sulfur Compounds in Biology
- Receptor Mechanisms and Signaling
- Alcohol Consumption and Health Effects
- Pharmacological Effects and Toxicity Studies
- Adipose Tissue and Metabolism
- Diet, Metabolism, and Disease
- Radiomics and Machine Learning in Medical Imaging
Osaka Metropolitan University
2022-2024
Tokyo Metropolitan University
2023-2024
East Japan Railway (Japan)
2023
Osaka City University
2006-2022
Osaka University of Pharmaceutical Sciences
2010-2022
Universidad Metropolitana
2022
Osaka City General Hospital
2022
Hospital for Sick Children
2014-2016
The University of Tokyo
2007
Kansai Medical University
1997-2006
Conflicting data regarding the ability of hydrogen sulfide (H2S), which reaches high levels in large intestine owing to biosynthesis intestinal cells and bacteria, promote or inhibit colorectal cancer cell proliferation have been reported recently. In present study, effect H2S on human line Caco-2 was examined by using donor GYY4137. At concentrations 0.5 mM 1.0 mM, GYY4137 significantly inhibited viability. Cell cycle analysis, apoptosis necrosis detection revealed that anti-proliferative...
Onasemnogene abeparvovec is an adeno-associated virus vector-based gene therapy for spinal muscular atrophy (SMA). Although several cases of drug-induced thrombotic microangiopathy due to onasemnogene have been reported, none has confirmed pathologically. Here, we present renal histopathologic findings TMA abeparvovec. On day 5 after receiving abeparvovec, a 23-month-old girl with SMA type 1 developed thrombocytopenia, microangiopathic hemolytic anemia, liver dysfunction, acute kidney...
Inorganic aluminum salts, such as sulfate, are coagulants that cause small particles, bacteria and viruses well inorganic to destabilize combine into larger aggregates. In this investigation, batch coagulation treatments of water samples spiked with Qbeta, MS2, T4, P1 were conducted four different coagulants. The total infectious virus concentration in the suspension floc particles eventually formed by dosing coagulant was measured after dissolved raising pH an alkaline beef extract...
Abstract Nociceptive primary afferents have the capacity to induce a state of increased excitability in dorsal horn neurons spinal cord or central sensitization causing thermal hyperalgesia and touch‐evoked pain (allodynia). It is believed that afferent C‐fibres become hypersensitive low‐threshold Aβ‐fibres are responsible for induction allodynia, mechanisms which remain elusive. We previously showed intrathecal administration prostaglandin E 2 (PGE ) F 2α (PGF allodynia conscious mice. Here...
Nociceptin/orphanin FQ (N/OFQ) is an opioid-like heptadecapeptide agonist for the opioid receptor homolog, N/OFQ receptor. To explore precise distribution of peptide-receptor system, authors examined brain and spinal cord from receptor-deficient mice bearing targeted mutation (morcm1), a lacZ insertional in gene. Precursor protein (preproN/OFQ) mRNA was detected by using situ hybridization, X-gal histochemistry. The reflected expression observed at high levels dentate gyrus, lateral septum,...
Abstract Translocation of soluble 12-lipoxygenase to membranes was examined in rat platelets. Preincubation platelet homogenates with 0.1-10 microM Ca2+ resulted an increase activity the particulate fraction a concomitant decrease that fraction. Kinetic parameters and membrane fractions were not changes presence 10 Ca2+. Ca2+-induced association dependent on amounts platelet-soluble but incubation temperature. 12-Lipoxygenase associated completely dissociated by reducing concentration nM....
The twin character of reactive oxygen species is substantiated by a growing body evidence that within cells act as inducers and accelerators the oncogenic phenotype cancer cells, while can also induce cell death therefore function anti-tumorigenic species. aim this study was to assess possible influence xanthine/xanthine oxidase on proliferation colorectal line Caco-2. (2.5 µM/0.25 mU/ml-25 µM/2.5 mU/ml) dose-dependently inhibited Caco-2 cells. Experiments utilizing scavengers (superoxide...
Epilepsy surgery can be successful in children with extensive congenital or early acquired focal hemispheric brain lesion on magnetic resonance imaging (MRI) despite generalized interictal epileptiform discharges (IEDs). The aim of this study was to assess if rapid eye movement (REM) sleep reduced IEDs and revealed lateralized identify the epileptogenic hemisphere normal/subtle changes MRI.We studied 20 scalp electroencephalography (EEG) MRI who underwent intracranial video-EEG for epilepsy...
Summary Objective To investigate whether the magnetoencephalography ( MEG ) single moving dipole SMD method could delineate epileptic zone of focal cortical dysplasia FCD at bottom sulcus FCDB ). Methods We retrospectively analyzed 17 children (11 male; mean age 8.8 years, range 3–17 years) with type II who underwent epilepsy surgery. compared spatial congruence between following: (1) cluster and (2) brain surface FCDS measured volume depth magnetic resonance imaging MRI )–visible lesions to...
Estrogen is neuroprotective against status epilepticus (SE)-induced hippocampal damage in female animals. In male animals, estrogen converted from testosterone via aromatization the activity of which upregulated by brain damage. However, it controversial whether or neuroinvasive after SE. order to understand role estrogen, important elucidate distribution manner receptor (ER)alpha and beta as targets estrogen. this study, we examined time course changes ERs adult rat hippocampus SE using...
Cortical resections in epilepsy surgery tend to involve multiple lobes children, compared adults, partly due underlying pathology. Oligodendroglia-like cells (OLCs) have been observed surgical specimens from children with pharmacoresistant epilepsy. We hypothesize that OLCs recruit multiple-lobe epileptogenic zones pediatric focal epilepsy.We examined the 30 who underwent (1.8- 16.9-years-old; mean age 9.7 years). Immunohistochemical assays of were performed using Olig2, which is a marker...
Abstract Panaxynol is a polyacetylene compound with anti-inflammatory and anti-platelet-aggregatory effects isolated from commonly used oriental medicines. The of panaxynol on the activity prostaglandin-synthesizing catabolizing enzymes in rabbit gastric antral mucosa have been examined. At concentrations ranging 25 to 200 μM had no effect synthesis prostaglandins E2, F2α D2 exogenous arachidonic acid microsomal fraction whereas at 25–200 it dose-dependently inhibited 15-hydroxyprostaglandin...