A5064604220- Pancreatic function and diabetes
- Diabetes and associated disorders
- Pancreatitis Pathology and Treatment
- Virology and Viral Diseases
- Ocular Disorders and Treatments
- Viral Infections and Immunology Research
- Retinal and Macular Surgery
- Biochemical effects in animals
- Metabolism, Diabetes, and Cancer
- Mosquito-borne diseases and control
- Intraocular Surgery and Lenses
- Diet and metabolism studies
- Adipose Tissue and Metabolism
Children’s Health Research Institute
2022-2025
Western University
2022
GlaxoSmithKline (United States)
2020
A Zika self-amplifying mRNA vaccine delivered by a flexible bedside mixing formulation induces protective immunity in NHPs.
Research into the effects of long-term antioxidant supplementation on islet microenvironment is limited. This study examined whether N-acetyl-L-cysteine (NAC) can prevent changes in metabolic outcomes, beta cell function, and pancreatic stellate (PaSC) activation aging mice. Male C57BL/6N mice at 18 weeks were administered 50 mM NAC through their daily drinking water treated for up to 60 weeks. Aging displayed lower body weights improved glucose tolerance but reduced insulin secretion...
Obesity plays a major role in type II diabetes (T2DM) progression because it applies metabolic and oxidative stress resulting dysfunctional beta-cells activation of intra-islet pancreatic stellate cells (PaSCs) which cause islet fibrosis. Administration antioxidant N-acetyl-L-cysteine (NAC) vivo improves outcomes diet-induced obese diabetic mice, vitro inhibits PaSCs activation. However, the effects NAC on islets are unknown. This study examined if dosage length treatment HFD-induced mice...