A5042624994- Hippo pathway signaling and YAP/TAZ
- Cellular Mechanics and Interactions
- Immune Response and Inflammation
- Single-cell and spatial transcriptomics
- Pluripotent Stem Cells Research
- Tendon Structure and Treatment
- Skin and Cellular Biology Research
- Advanced Biosensing Techniques and Applications
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Anodic Oxide Films and Nanostructures
- Wound Healing and Treatments
Johns Hopkins University
2021-2022
Creative Commons
2022
Johns Hopkins Medicine
2021-2022
Uniquely among mammalian organs, skin is capable of marked size change in adults, yet the mechanisms underlying this notable capacity are unclear. Here, we use a system controlled tissue expansion mice to uncover cellular and molecular determinants growth. Through machine learning-guided three-dimensional reconstruction, capture morphometric changes growing skin. We find that most growth driven by proliferation epidermis response mechanical tension, with more limited dermal subdermal...
Abstract Fibrosis is a major health burden across diseases and organs. To remedy this, we study wound‐induced hair follicle neogenesis (WIHN) as model of non‐fibrotic healing that recapitulates embryogenesis for de novo morphogenesis after wounding. We previously demonstrated TLR3 promotes WIHN through binding wound‐associated dsRNA, the source which still unclear. Here, find multiple distinct contexts high all show strong neutrophil signature. Given correlation between infiltration...
PURPOSE: To uncover cellular and molecular determinants of skin growth with the goal designing future therapies for conditions excess or inadequate skin. Current research in field has identified distinct populations stem cells within specific components that regularly replenish epidermis hair follicles. METHODS: A controlled tissue expansion mouse model was applied to all variables interest. We used Lgr5/6-EGFP-CreERT2;tdTomato mice lineage trace Lgr5/6+ cell progeny. YAP gain-...
Purpose: Current research in the field of wound regeneration has identified distinct populations stem cells within specific skin components that regularly replenish epidermis and hair follicles. The purpose this study was to identify cellular molecular determinants growth establish a platform for designing therapeutic strategies conditions excess or inadequate growth. Methods: Young adult mice underwent controlled tissue expansion back skin. Lgr5/6-EGFP-CreERT2;tdTomato were used lineage...