A5049318081- Fish Ecology and Management Studies
- Reproductive biology and impacts on aquatic species
- Birth, Development, and Health
- Cholesterol and Lipid Metabolism
- Aquaculture Nutrition and Growth
- Environmental Toxicology and Ecotoxicology
- Physiological and biochemical adaptations
- Cancer, Lipids, and Metabolism
- MicroRNA in disease regulation
- Zebrafish Biomedical Research Applications
- Aquaculture disease management and microbiota
- Toxic Organic Pollutants Impact
- Effects and risks of endocrine disrupting chemicals
- Microplastics and Plastic Pollution
- Fatty Acid Research and Health
- Mercury impact and mitigation studies
- Pharmaceutical and Antibiotic Environmental Impacts
- Lipid metabolism and biosynthesis
University of California, Riverside
2019-2023
Bifenthrin (BF) is a widely used pyrethroid that has been frequently detected in surface waters. Previous studies indicated BF had antiestrogenic activity zebrafish embryos but estrogenic posthatch fish. To determine whether age-related differences metabolism contribute to the endocrine effects developing fish, from and Japanese medaka were exposed before after liver development. Since commercial mixture of an isomer-enriched product containing two enantiomers (1R-cis-BF 1S-cis-BF),...
Abstract Polycyclic aromatic hydrocarbons (PAHs) are pervasive pollutants in aquatic ecosystems, and developing fish embryos especially sensitive to PAH exposure. Exposure crude oil or phenanthrene (a reference found oil) produces an array of gross morphological abnormalities embryos, including cardiotoxicity. Recently, studies utilizing transcriptomic analyses several oil‐exposed significant changes the abundance transcripts involved cholesterol biosynthesis. Given vital role availability...
Projected water temperature increases based on predicted climate change scenarios and concomitant pesticide exposure raises concern about the responses of aquatic organisms. To better understand effect mixtures influence to fish, juvenile Chinook salmon (Oncorhynchus tshawytscha) were dietarily exposed a mixture legacy current use pesticides (p,p'-DDE, bifenthrin, chlorpyrifos, esfenvalerate, fipronil) at concentrations detected from field-collected prey items in Sacramento-San Joaquin...
Dysregulation of microRNA (miRNA, miR) by environmental stressors influences the transcription mRNA which may impair organism development and/or lead to adverse physiological outcomes. Early studies evaluating effects oil on developmental toxicity in early life stages fish showed that reductions expression miR-203a were associated with enhanced downstream mRNAs predicted altered eye development, cardiovascular disease, and improper fin development. To better understand inhibition as an...
Previous studies have shown that altered expression of a family small noncoding RNAs (microRNAs, or miRs) regulates the downstream mRNAs and is associated with diseases developmental disorders. miR133b highly expressed in mammalian cardiac skeletal muscle, aberrant disorders electrophysiological changes cardiomyocytes. Similarly, dysfunction has been observed early life-stage mahi-mahi (Coryphaena hippurus) exposed to crude oil, phenotype an upregulation as well subsequent downregulation...
The global sequencing of microRNA (miRNA; miR) and integration to downstream mRNA expression profiles in early life stages (ELS) fish following exposure crude oil determined consistently dysregulated miRNAs regardless the source or species. overlay differentially expressed mRNAs into silico software that key roles these were predicted be involved cardiovascular, neurological visually-mediated pathways. Of these, altered miRNAs, miR-203a miR-34b primary targets oil. To better characterize...
The 2010 Deepwater Horizon oil spill impacted over 2100 km of shoreline along the northern Gulf Mexico, which coincided with spawning season many coastal species, including red drum (Sciaenops ocellatus). Red develop rapidly and are sensitive to crude exposure during embryonic larval periods. This study investigates predictions from recent transcriptomic studies that cholesterol biosynthetic processes by in fish early life stages. We found larvae exposed for 72 h ΣPAH50 3.55-15.45 µg L-1...
Lecithotrophic fish embryos rely on finite maternally deposited yolk resources for early development. Toxicant exposure can disrupt the uptake of with consequences In this study, we investigate impacts altered utilization using cardiotoxic compound phenanthrene. Zebrafish were exposed to a concentration phenanthrene beginning at 6 hpf (hours post-fertilization) until maximum 72 hpf. Embryos stained Oil Red O visualize neutral lipids. We then used nontargeted approach profile lipids in 24 and...