A5044312760- Veterinary Equine Medical Research
- Asthma and respiratory diseases
- Immune Response and Inflammation
- Exercise and Physiological Responses
- Reproductive Physiology in Livestock
- Allergic Rhinitis and Sensitization
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Respiratory and Cough-Related Research
- T-cell and B-cell Immunology
- Shoulder Injury and Treatment
- Mesenchymal stem cell research
- Wound Healing and Treatments
- Pulmonary Hypertension Research and Treatments
- Andrographolide Research and Applications
- Antimicrobial Peptides and Activities
- Antifungal resistance and susceptibility
- Effects of Environmental Stressors on Livestock
- Food Allergy and Anaphylaxis Research
- Tendon Structure and Treatment
- Immune cells in cancer
- Developmental and Educational Neuropsychology
- Sports injuries and prevention
- Medicinal Plant Pharmacodynamics Research
- Traumatic Ocular and Foreign Body Injuries
- Invertebrate Immune Response Mechanisms
Austral University of Chile
2014-2024
University of Buenos Aires
2016-2019
Abstract Background and objective Neutrophilic asthma is an important disease subgroup, including patients with severe phenotypes erratic responses to standard treatments. T amoxifen ( TX ), a selective estrogen receptor modulator SERM ) used as treatment of human breast cancer, has been shown induce early apoptosis equine blood bronchoalveolar lavage fluid BALF neutrophils in vitro. Equine recurrent airway obstruction RAO naturally occurring neutrophilic condition, closely related asthma....
Mesenchymal stem/stromal cells (MSCs) are increasingly explored for the treatment of degenerative and inflammatory diseases in human veterinary medicine. One key characteristics MSCs is that they modulate inflammation mainly through secretion soluble mediators. However, despite widespread clinical use, knowledge regarding effector mechanisms equine MSCs, consequently their effectiveness diseases, still unknown. The objectives this study were to determine underlying inhibition lymphocyte...
Abstract Neutrophilic bronchiolitis is the primary lesion in asthma-affected horses. Neutrophils are key actors host defense, migrating toward sites of inflammation and infection, where they act as early responder cells external insults. However, neutrophils can also mediate tissue damage various non-infectious inflammatory processes. Within airways, these likely contribute to bronchoconstriction, mucus hypersecretion, pulmonary remodeling by releasing pro-inflammatory mediators, including...
In this study, the presence and characteristics of recurrent airway obstruction (RAO), in Chilote horses were investigated.The horse is a breed small very rustic horses, descendent from that brought by spaniards during colony remained isolated Chiloe island, south Chile, for long time.Twenty two animals, all same farm living under similar conditions, physically examined.In cases broncheoalveolar lavage (BALF) was performed recovered resident cells respiratory tract studied smears stained...
Neutrophils display an array of biological functions including the formation neutrophil extracellular traps (NETs), web-like structures specialized in trapping, neutralizing, killing and preventing microbial dissemination within host. However, NETs contribute to a number inflammatory pathologies, severe equine asthma. Tamoxifen (TX) is selective estrogen receptor modulator which belongs triphenylethyllenes group molecules, used as treatment all stages estrogen-positive human breast cancer....
Lameness associated to joint disease (JD) in athlete equines is an important cause of economic losses.Intensive training produces biomechanical overload the synovial joints with a consequent activation metalloproteinases, which have been pathogenesis equine JD.This characterized by degradation extracellular matrix (ECM) articular cartilage causing release structural components space and producing changes fluid concentration these ECM components, termed biomarkers.The some proteins might be...
El objetivo de este estudio fue determinar si ratones expuestos a esporas Aspergillus fumigatus desarrollan una inflamación alérgica las vías respiratorias similar la observada en equinos con Obstrucción Recurrente Vías Aéreas (ORVA).Para esto se utilizaron Rockefeller (RK) 2, 5, 6 y 8 meses respectivamente, los cuales mantuvieron por 16 días jaulas que contenían heno contaminado A. fumigatus.Posterior exposición, animales fueron sangrados sacrificados para obtención suero sanguíneo, lavado...