A5080192946- Health Systems, Economic Evaluations, Quality of Life
- Genomics and Rare Diseases
- Pharmaceutical Economics and Policy
- BRCA gene mutations in cancer
- Economic and Financial Impacts of Cancer
- Biotechnology and Related Fields
- Autism Spectrum Disorder Research
- Biomedical Ethics and Regulation
- Cancer Genomics and Diagnostics
- Family and Disability Support Research
- Demographic Trends and Gender Preferences
- Clinical practice guidelines implementation
- CRISPR and Genetic Engineering
- Cytomegalovirus and herpesvirus research
- Cystic Fibrosis Research Advances
- Multiple and Secondary Primary Cancers
- Renal Diseases and Glomerulopathies
- Ophthalmology and Eye Disorders
- Healthcare Systems and Public Health
- Migraine and Headache Studies
- Genomic variations and chromosomal abnormalities
- Economic Issues in Ukraine
- Intergenerational Family Dynamics and Caregiving
- Artificial Intelligence in Healthcare and Education
- Diabetes and associated disorders
Medical University Plovdiv
2016-2025
Faculty of Public Health
2014-2024
University Multipurpose Hospital for Active Treatment "Sveti Georgi"
2018
Plovdiv University
2016
Bulgarian Association for the Promotion of Citizens Initiative
2014
Mario Negri Institute for Pharmacological Research
2000-2008
Provision of a molecularly confirmed diagnosis in timely manner for children and adults with rare genetic diseases shortens their "diagnostic odyssey," improves disease management, fosters counseling respect to recurrence risks while assuring reproductive choices. In general clinical genetics setting, the current diagnostic rate is approximately 50%, but those who do not receive molecular after initial evaluation, that much lower. Diagnostic success these more challenging affected...
Rare cancers, defined as those with an annual incidence of fewer than six cases per 100,000 individuals, are associated significant health inequalities. This study aimed to assess the knowledge, attitudes, and perceptions healthcare providers expertise in rare cancers regarding effectiveness enacted or planned cancer policies across Europe. Between 25 March 2023 5 2024, we conducted online survey targeting 738 affiliated European Reference Networks Organization Cancer Institutes, yielding 92...
Background/Objectives: The objective of our study was to quantify the annual costs, from a societal perspective, encompassing direct health care non-health and labor productivity losses associated with spinal muscular atrophy (SMA) patients in Bulgaria their caregivers. Methods: We applied prevalence-based, bottom-up costing methodology assess socio-economic burden SMA perspective. evaluated summed up all costs for services (diagnosis, treatment, follow-up, rehabilitation), educational...
Rare cancers, defined by an annual incidence of fewer than 6 per 100,000 cases, pose significant challenges due to their complexity, lack expertise, and limited treatment options. In Bulgaria, these are compounded resources, fragmented care, outdated policies. This study investigates policy stakeholder perspectives identify gaps propose alternatives for rare cancer care in with implications the broader European Union (EU) context. A grounded theory qualitative research design was employed...
Over the last decade European Union has been coordinating actions addressing various aspects of rare diseases and funded several cross-border research projects. Recently initiated biggest disease international collaborative effort by launching International Rare Diseases Research Consortium (IRDiRC). RARE-Bestpractices is one more than 100 projects on under Seventh Framework Programme for Technological Development (FP7; 2007-2013) (1). As a wide, open inclusive network, will build knowledge...
Limited resources and expanding expectations push all countries types of health systems to adopt new approaches in priority setting allocation. Despite best efforts, it is difficult reconcile competing interests, trade-offs are inevitable. This why multi-criteria decision analysis (MCDA) has played a major role recent uptake value-based reimbursement. MCDA framework enables exploration stakeholders' preferences, as well explicit organization broad range criteria on which real-world decisions...
Abstract Research providing an evidence-base for autistic adult services is sparse. The Autism Spectrum Disorders in the European Union (ASDEU) network implemented on-line survey to determine gaps diagnostic evaluation and post-diagnostic support services. More than 55% all groups experienced most of recommended features adults. In contrast, < 2% adults or carers, 21% professionals each support. contrast 61% professionals, only about 30% carers had knowledge good local models autism...
The European Union (EU) policy for healthcare requires the establishment of a system Reference Networks, union-wide information databases, and registries rare diseases (RDs) based on shared criteria. In pursuing its goals, ‘Building Consensus Synergies EU Registration RD Patients in Europe' (EPIRARE) project convened meeting with experts competent health authorities to discuss role national institutional patient supporting registration room international cooperation. With this aim, paper...
Given the increased availability of data sources such as hospital information systems, electronic health records, and health-related registries, a novel approach is required to develop artificial intelligence-based decision support that can assist clinicians in their diagnostic decision-making shorten rare disease patients' odyssey. The aim identify key challenges process mapping European databases, relevant ML-based screening technologies terms organizational, FAIR legal principles.A...
Abstract Background The delay in diagnosis for rare disease (RD) patients is often longer than with common diseases. Machine learning (ML) technologies have the potential to speed up and increase precision of this population group. We aim explore expectations experiences members European Reference Networks (ERNs) RDs those their application. Methods used a mixed-methods approach an online survey followed by focus group discussion. Our study targeted primarily medical professionals but also...
Abstract Background Patient registries and databases are essential tools for advancing clinical research in the area of rare diseases, as well enhancing patient care healthcare planning. The primary aim this study is a landscape analysis available European data sources amenable to machine learning (ML) their usability Rare Diseases screening, terms findable, accessible, interoperable, reusable(FAIR), legal, business considerations. Second, recommendations will be proposed provide better...
Rare cancers are defined by an annual incidence of fewer than 6 per 100,000. Bearing similarities to rare diseases, they associated with substantial health inequalities due diagnostic complexity and delayed access innovative therapies. This situation is further aggravated in Southeastern European countries like Bulgaria, where limited public resources expertise underscore the need for additional policy translational research on cancers. study aimed explore availability orphan drugs Bulgaria...
Abstract: This study aims to explore the current rationale of post-marketing access orphan drugs. As medicinal products depends on assessment and appraisal by health authorities, this article is focused technology (HTA) reimbursement decision-making considerations for A critical analysis may identify important factors that could predetermine combined outcomes these two processes. Following objective, an analytical framework was developed, comprising three overlaying issues: outline what...
Myasthenia gravis (MG) is a chronic autoimmune disorder, which characterized by fatigable muscle weakness with frequent ocular signs and/or generalized fatigue, and occasionally associated thymoma. MG patients their families face significant socio-economic burden. This population often experiencing unemployment, unwilling job transfers decreased income.This study aimed to estimate the annual costs from societal perspective in triple dimension of direct health care costs, non-health (formal...
Background: During times of fiscal austerity, means reimbursement decision-making are particular interest for public health theory and practice.Introduction advanced technologies, growing expenditures increased scrutiny over drug decisions have pushed governments to consider mechanisms that promote the use effective while constraining costs.Aims: The study's aim was explore current rationale framework in Bulgaria.Our pilot research focused on one component this process -the criteria used...
Preconception care (PC) is relatively new area of practice. While the volume and quality PC activities depend on local settings, awareness women critical for successful promotion services. The aim this study was to examine preconception-health-related attitudes experiences Bulgarian reproductive age. A qualitative conducted among 20 aged 18 49 years performed between May July 2022. Two focus groups were used with mixed samples nulligravida, pregnant, postpartum women. participants thought...