A5066866450- Spinal Cord Injury Research
- Cerebral Palsy and Movement Disorders
- Bone fractures and treatments
- Muscle activation and electromyography studies
- Nerve Injury and Rehabilitation
- Hip disorders and treatments
- Stroke Rehabilitation and Recovery
- Hip and Femur Fractures
- Bone health and osteoporosis research
- Bone and Joint Diseases
- Bone Metabolism and Diseases
- EEG and Brain-Computer Interfaces
- Osteoarthritis Treatment and Mechanisms
- Spinal Fractures and Fixation Techniques
- Traumatic Ocular and Foreign Body Injuries
- Balance, Gait, and Falls Prevention
- Neuroscience and Neural Engineering
- Trauma and Emergency Care Studies
- Musculoskeletal pain and rehabilitation
- Dysphagia Assessment and Management
- Musculoskeletal Disorders and Rehabilitation
- Trauma Management and Diagnosis
- Medical Imaging and Analysis
- Neurogenetic and Muscular Disorders Research
- Advanced X-ray and CT Imaging
Queen Elizabeth University Hospital
2016-2024
University of Strathclyde
2014-2024
Cardiff University
2021
Southern General Hospital
2008-2015
University of Glasgow
2008-2015
Institute for Research and Innovation in Social Services
2013
To investigate adaptive changes in bone and muscle parameters the paralysed limbs after detraining or reduced functional electrical stimulation (FES) induced cycling following high-volume FES-cycling chronic spinal cord injury.Five subjects with motor-sensory complete injury (age 38.6 years, lesion duration 11.4 years) were included. Four stopped completely training phase whereas one continued (2-3 times/week, for 30 min).Bone assessed legs using peripheral quantitative computed tomography...
Tetraplegic volunteers undertook progressive exercise training, using novel systems for arm-cranking assisted by Functional Electrical Stimulation (FES). The main aim was to determine potential training effects of FES-assisted arm-crank ergometry (FES-ACE) on upper limb strength and cardiopulmonary (fitness) in tetraplegia. Surface FES applied the biceps triceps during an instrumented ergometer. Two tetraplegic with C6 Spinal Cord Injury (SCI) went through muscle strengthening, baseline...
Body-weight-supported robot-assisted devices can be used to promote gait rehabilitation and as exercise tools for neurologically impaired persons such stroke spinal-cord-injured patients. Here, we propose a novel feedback-control structure real-time control of oxygen uptake during gait, in which use the following methods. 1) A is proposed, consisting dynamic controller operating on target actual levels order set work rate. Target rate achieved by an inner volitional feedback loop relies...
Damage to the spinal cord compromises motor function and sensation below level of injury, resulting in paralysis progressive secondary health complications.Inactivity reduced energy requirements result cardiopulmonary fitness an increased risk coronary heart disease cardiovascular complications.These risks may be minimized through regular physical activity.It is proposed that such activity should begin at earliest possible time point after before extensive neuromuscular degeneration has...
The disuse-related bone loss that results from immobilisation following injury shares characteristics with osteoporosis in post-menopausal women and the aged, decreases mineral density leading to weakening of increased risk fracture. aim this study was use finite element method to: (i) calculate mechanical response tibia under load (ii) estimate fracture; comparing between two groups, an able-bodied group spinal cord patients suffering varying degrees loss. tibiae eight male subjects chronic...
Micro-Computed Tomography bone analysis is the gold standard method for assessing trabecular and cortical microarchitecture in small animal bones. This technique reports morphometric parameters as averages over selected volumes of interest (VOIs). study proposes introduction an additional global 2D step into process, that provides a survey underlying variation present throughout both bone. The visualisation these distributions systematic approach to VOI selection rationale adds confidence...
People with spinal cord injury (SCI) experience bone loss and have an elevated rate of fracture in the paralysed limbs. The literature suggests exponential time course after SCI, but true rates may vary between patients. We propose systematic evaluation status early stages SCI to identify fast losers.A case series six patients complete were scanned using peripheral quantitative computed tomography within 5 weeks at 4, 8 12 months post-injury. Bone mineral density (BMD) content (BMC) measured...
Osteoporosis disrupts the fine-tuned balance between bone formation and resorption, leading to reductions in quantity quality ultimately increasing fracture risk. Prevention treatment of osteoporotic fractures is essential for mortality, morbidity, economic burden, particularly considering aging global population. Extreme loss that mimics time-accelerated osteoporosis develops paralyzed limbs following complete spinal cord injury (SCI). In vitro nanoscale vibration (1 kHz, 30 or 90 nm...
Bruising is an injury commonly observed within suspect cases of assault or abuse, yet how a blunt impact initiates bruising and influences its severity not fully understood. Furthermore, the standard method documenting bruise with colour photography known to have limitations which influence already subjective analysis bruise. This research investigated using standardised impact, delivered 18 volunteers. The resulting was imaged colour, cross polarised (CP) infrared photography. Timelines...
Characterise the spatiotemporal responses of trabecular and cortical bone to complete spinal cord injury (SCI) in skeletally mature rat acute (4-week) period following injury.The 5-month old male rats was transected at T9 level. Outcome measures were assessed using micro-computed tomography, three-point bending serum markers 1-, 2-, 4-weeks post-transection. Comparison made with time-0 sham animals.Lower levels circulating formation higher resorption suggested uncoupled turnover as early...
Abstract Osteoporosis disrupts the fine-tuned balance between bone formation and resorption leading to reductions in quantity quality, ultimately increased fracture risk. Prevention treatment of osteoporotic fractures is essential, for mortality, morbidity economic burden, particularly considering ageing global population. Extreme loss that mimics time-accelerated osteoporosis develops paralysed limbs following complete spinal cord injury (SCI). In vitro nanoscale vibration (1 kHz, 30- or 90...
Abstract Summary Fibular response to disuse has been described in cross-sectional but not longitudinal studies. This study assessed fibular bone changes people with spinal cord injury. loss was less than the tibia and correlated together. might explain low fracture incidents these patients. Purpose Cross-sectional studies suggest that fibula responds differently loading compared tibia. Whilst tibial following injury (SCI) have established studies, remain unexplored. Methods parameters were...