A5003341988- Bone Tissue Engineering Materials
- Cellular Mechanics and Interactions
- Bone fractures and treatments
- Periodontal Regeneration and Treatments
- Bone Metabolism and Diseases
- Osteoarthritis Treatment and Mechanisms
- Polymer Surface Interaction Studies
- Bacterial biofilms and quorum sensing
- biodegradable polymer synthesis and properties
- Liver physiology and pathology
- Orthopedic Infections and Treatments
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Liver Disease Diagnosis and Treatment
- Orthopaedic implants and arthroplasty
University of Glasgow
2019-2024
Poly-l-lactic acid (PLLA) has been used as a biodegradable polymer for many years; the key characteristics of this make it versatile and useful resource regenerative medicine. However, is not inherently bioactive. Thus, here, novel process presented to functionalize PLLA surfaces with poly(ethyl acrylate) (PEA) brushes provide biological functionality through PEA's ability induce spontaneous organization extracellular matrix component fibronectin (FN) into physiological-like nanofibrils....
Osteoporosis disrupts the fine-tuned balance between bone formation and resorption, leading to reductions in quantity quality ultimately increasing fracture risk. Prevention treatment of osteoporotic fractures is essential for mortality, morbidity, economic burden, particularly considering aging global population. Extreme loss that mimics time-accelerated osteoporosis develops paralyzed limbs following complete spinal cord injury (SCI). In vitro nanoscale vibration (1 kHz, 30 or 90 nm...
In article number 1801469 by Manuel Salmerón-Sánchez, Marco Cantini, and co-workers, functional poly(ethyl acrylate) brushes grafted on a biodegradable poly lactic acid scaffold, via surface-initiated atomic transfer radical polymerization, trigger the formation of fibronectin nanonetworks that target cell adhesion differentiation for application in regenerative medicine. The cover image was prepared Mark Robert Sprott Sara Trujillo.
Abstract Osteoporosis disrupts the fine-tuned balance between bone formation and resorption leading to reductions in quantity quality, ultimately increased fracture risk. Prevention treatment of osteoporotic fractures is essential, for mortality, morbidity economic burden, particularly considering ageing global population. Extreme loss that mimics time-accelerated osteoporosis develops paralysed limbs following complete spinal cord injury (SCI). In vitro nanoscale vibration (1 kHz, 30- or 90...
Fibronectin (FN) mediates cell-material interactions during events such as tissue repair, and therefore the biomimetic modeling of this protein in vitro benefits regeneration. The nature interface is crucial determining cell adhesion, morphology, differentiation. Poly(ethyl acrylate) (PEA) spontaneously organizes FN into biological nanonetworks, resulting exceptional bone regeneration animal models. Spontaneous network organization also observed poly(buthyl (PBA) substrates that have higher...
Abstract Post-operative infection is a major complication in patients recovering from orthopaedic surgery. As such, there clinical need to develop biomaterials for use regenerative surgery that can promote mesenchymal stem cell (MSC) osteospecific differentiation and prevent caused by biofilm-forming pathogens. Nanotopographical approaches pathogen control are being identified, including materials such as titanium its alloys. These topographies high aspect ratio nanospikes or nanowires...