A5027962007- Pregnancy and preeclampsia studies
- RNA regulation and disease
- interferon and immune responses
- Gestational Diabetes Research and Management
- DNA Repair Mechanisms
- Birth, Development, and Health
- PARP inhibition in cancer therapy
- Nursing Roles and Practices
- RNA Research and Splicing
- MicroRNA in disease regulation
- Migration, Aging, and Tourism Studies
- Intergenerational Family Dynamics and Caregiving
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Polyomavirus and related diseases
- Preterm Birth and Chorioamnionitis
- Extracellular vesicles in disease
- Trauma and Emergency Care Studies
- Pregnancy-related medical research
- Uterine Myomas and Treatments
- Emergency and Acute Care Studies
- Health disparities and outcomes
- Viral Infections and Immunology Research
- Herpesvirus Infections and Treatments
- Microtubule and mitosis dynamics
- Maternal and Perinatal Health Interventions
University of California, Irvine
2024-2025
University of California, San Diego
2021-2024
Jacobs (United States)
2022
OAS-RNase L is a double-stranded RNA-induced antiviral pathway triggered in response to diverse viral infections. Upon activation, suppresses virus replication by promoting the decay of host and RNAs inducing translational shutdown. However, whether OASs RNase are only factors involved this remains unclear. Here, we develop CRISPR-Translate, FACS-based genome-wide CRISPR-Cas9 knockout screening method that uses translation levels as readout identifies IRF2 key regulator OAS3....
Ataxia telangiectasia and Rad3-related (ATR) inhibition triggers a surge in origin firing, resulting increased levels of single-stranded DNA (ssDNA) that rapidly deplete all available RPA. This leaves ssDNA unprotected susceptible to breakage, phenomenon known as replication catastrophe. However, the mechanism by which breaks remains unclear. Here, we reveal APOBEC3B is key enzyme targeting at forks, initiating reaction cascade induces fork collapse poly(ADP-ribose) polymerase 1 (PARP1)...
ATR is the master safeguard of genomic integrity during DNA replication. Acute inhibition with inhibitor (ATRi) triggers a surge in origin firing, leading to increased levels single-stranded (ssDNA) that rapidly deplete all available RPA. This leaves ssDNA unprotected and susceptible breakage, phenomenon known as replication catastrophe. However, mechanism by which breaks remains unclear. Here, we reveal APOBEC3B key enzyme targeting at forks, triggering reaction cascade induces fork...
BACKGROUNDThreatened preterm birth is the most common reason for antepartum hospitalization in United States, accounting approximately 50% of these admissions. However, fewer than 10% patients with inpatient evaluation signs or symptoms labor ultimately deliver before term.OBJECTIVEThis study aimed to generate predictive models assess risk delivery and time based on clinical evaluated our institution concerns.STUDY DESIGNThis was a retrospective cohort singleton pregnancies and/or labor,...
Abstract Disclosure: J. Cassin: None. D.L. Keefe: K.E. Sung: C.C. Bojo: G. Santiago: L. Plummer: K.B. Salnikov: S.B. Seminara: R. Balasubramania: P.L. Mellon: Isolated Hypogonadotropic Hypogonadism (IHH) is a condition marked by absent pubertal development and low sex steroids in the setting of low/normal gonadotropins. Mutations known IHH genes only explain <50% genetic etiology suggesting significant missing heritability IHH. To explore this heritability, we examined whole exome...
ABSTRACT Double-stranded RNAs (dsRNAs) produced during viral infections are recognized by the innate immune sensor protein kinase R (PKR), triggering a host translation shutoff that inhibits replication and propagation. Given harmful effects of uncontrolled PKR activation, cells must tightly regulate to ensure its activation occurs only in response infections, not endogenous dsRNAs. Here, we use CRISPR-Translate, FACS-based genome-wide CRISPR-Cas9 knockout screening method exploits levels as...
<title>Abstract</title> Background: The rising prevalence of maternal obesity presents a significant health concern because the possible implications for obstetric complications and neonatal outcomes. Understanding impact on placental structure function as well fetal growth infant outcomes is important to improve care these potentially high-risk pregnancies. This study aimed determine effect elevated BMI histopathologic patterns injury its consequences growth. Methods: Data were collected...
Abstract The UC San Diego MADURA Mentorship Program, funded by an R25 National Institute on Aging grant, has goals to improve diversity in and Alzheimer’s Disease (ADRD) research clinical practice. strives retention academic success of its URM trainees, increase graduate/medical school applications and/or entry into Aging/ADRD careers. Mentees receive paid experience, skills training, peer support, seminars, additional professional development opportunities. Given local demographics...