A5074934220- Adipose Tissue and Metabolism
- Mitochondrial Function and Pathology
- Environmental Toxicology and Ecotoxicology
- Toxic Organic Pollutants Impact
- Diet and metabolism studies
- Marine Biology and Ecology Research
- Metabolomics and Mass Spectrometry Studies
- Protein Hydrolysis and Bioactive Peptides
- Heavy metals in environment
- Isotope Analysis in Ecology
- Lipid metabolism and biosynthesis
- Marine and fisheries research
- Effects and risks of endocrine disrupting chemicals
- Reproductive biology and impacts on aquatic species
- ATP Synthase and ATPases Research
- Cancer, Hypoxia, and Metabolism
- Muscle metabolism and nutrition
- Mercury impact and mitigation studies
- Biochemical effects in animals
- Apelin-related biomedical research
- Petroleum Processing and Analysis
- Peroxisome Proliferator-Activated Receptors
- Radioactive contamination and transfer
- Ubiquitin and proteasome pathways
- Cancer-related gene regulation
Dalhousie University
2020-2025
Saint John Regional Hospital
2020-2024
University of New Brunswick
2013-2023
Faculty (United Kingdom)
2021
Deregulation of lipid metabolism and insulin function in muscle adipose tissue are hallmarks systemic resistance, which can progress to type 2 diabetes. While previous studies suggested that milk proteins influence glucose homeostasis function, it remains unclear whether bioactive peptides generated from whey alter its accumulation tissue. Therefore, we incubated murine 3T3-L1 preadipocytes C2C12 myotubes with a peptide mixture produced through pepsin-pancreatin digestion, mimicking the gut...
Historic forest management practices led to widespread aerial application of insecticides, such as dichlorodiphenyltrichloroethane (DDT), North American conifer forests during ∼1950-1970. Lake basins thus may provide an important archive inputs and aquatic responses these organochlorines. We use dated sediment cores from five study lakes in multiple watersheds New Brunswick (NB), Canada, a regional paleo-ecotoxicological perspective on this potential legacy stressor remote lake ecosystems....
Branched-chain α-keto acids (BCKAs) are catabolites of branched-chain amino (BCAAs). Intracellular BCKAs cleared by ketoacid dehydrogenase (BCKDH), which is sensitive to inhibitory phosphorylation BCKD kinase (BCKDK). Accumulation an indicator defective BCAA catabolism and has been correlated with glucose intolerance cardiac dysfunction. However, it unclear whether directly alter insulin signaling function in the skeletal muscle cell. Furthermore, role excess fatty (FAs) perturbing BCKA...
Lipid phosphate phosphatase 3 (LPP3) is a membrane-bound enzyme that hydrolyzes lipid phosphates including the bioactive lipid, lysophosphatidic acid (LPA). Elevated circulating LPA production and cellular signaling are implicated in obesity-induced metabolic cardiac dysfunction. Deletion of LPP3 cardiomyocyte increases levels causes heart failure mitochondrial dysfunction mice. To examine influence modulation on cardiomyopathy, we generated mice with cardiomyocyte-specific overexpression...
Abstract Triple-negative breast cancers (TNBCs) are characterized by poor survival, prognosis, and gradual resistance to cytotoxic chemotherapeutics, like doxorubicin (DOX). The clinical utility of DOX is limited its cardiotoxic chemoresistant effects that manifest over time. To induce chemoresistance, TNBC rewires oncogenic gene expression cell signaling pathways. Recent studies have demonstrated reprogramming branched-chain amino acids (BCAAs) metabolism facilitates tumor growth survival....
Myocardial infarction and reperfusion constitute a complex injury consisting of many distinct molecular stress patterns that influence cardiomyocyte survival adaptation. Cell signalling, which is essential to cardiac development, also presents potential disease-modifying opportunities recover limit myocardial or maladaptive remodelling. Here, we hypothesized Yap signalling could be sensitive one more associated with early acute ischemia. We found Yap, not Taz, expression differed in...
Haskap (Lonicera caerulea L.) berry is enriched in anthocyanins, primarily cyanidin-3-O-β-glucoside (C3G). It remains unknown whether C3G counteracts metabolic alterations of the pathogenesis obesity. In this study, mice were fed high-fat high-sucrose (HFHS) diet supplemented either with C3G-rich extract (HFHS + CE) or powder low BP). Mice HFHS CE displayed short-term protection against weight gain, independent food intake. had lower hepatic diacylglycerols and triacylglycerols content...
To investigate impacts of proposed oil sands aquatic reclamation techniques on benthic fish, white sucker (Catostomus commersonii Lacépède, 1803) were stocked in 2 experimental ponds-Demonstration Pond, containing aged fine tailings capped with fresh water, consistent end-pit lake designs, and South Bison unextracted material-to examine the effects unmodified hydrocarbons. White from a nearby reservoir at both sites May 2010 sampled 4 mo later to measure indicators energy storage...
Background: Predicting relapses of post-operative complications in obese patients who undergo cardiac surgery is significantly complicated by persistent metabolic maladaptation associated with obesity. Despite studies supporting the linkages increased systemic branched chain amino acids (BCAAs) driving pathogenesis obesity, metabolome wide have either supported or challenged association circulating BCAAs cardiovascular diseases (CVDs). Objective: We interrogated whether BCAA catabolic...
Abstract Myocardial infarction and reperfusion is a complex injury consisting of many distinct molecular stress patterns that influence cardiomyocyte survival adaptation. Cell signalling essential to cardiac development also presents potential disease-modifying opportunities recover limit myocardial or maladaptive remodelling. Here we hypothesized Yap could be sensitive one more associated with early acute ischemia. Yap, not Taz, expression differ in post-myocardial infarct compared...
Quantitative proteins analysis was carried out in the hypothalamus of zebrafish following dietary exposure to legacy pesticide dieldrin. Data were collected using iTRAQ labeling methodology and data acquired a hybrid quadrupole Orbitrap (Q Exactive) MS system (Thermo Fisher Scientific, Bremen, Germany). There 3941 identified zebrafish, these comprised 23 unique expression patterns for based on three doses 226 that regulated one or more dieldrin 3715 not affected. Thus, 5.7% detected...
Abstract Infaunal invertebrate communities of coastal marine sediments are often impacted by human activities, particularly in harbours and estuaries. However, while many studies have attempted to identify the key factors affecting benthic infauna, few done so for highly energetic tidal Samples were collected over a decade (2011–2020) from series reference sites Saint John Harbour (45.25° N, 66.05° W), estuary Bay Fundy, Canada. These data used examine spatial temporal trends infaunal...
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Abstract Branched-chain α-keto acids (BCKAs) are downstream catabolites of branched-chain amino (BCAAs). Mitochondrial oxidation BCKAs is catalyzed by ketoacid dehydrogenase (BCKDH), an enzyme sensitive to inhibitory phosphorylation BCKD kinase (BCKDK). Emerging studies show that defective BCAA catabolism and elevated levels correlate with glucose intolerance cardiac dysfunction. However, if/how BCKDH BCKDK exert control on the availability flux intramyocellular if BCKA reprograms nutrient...
Consumption of milk-derived whey proteins has been demonstrated to have insulin-sensitizing effects in mice and humans, part through the generation bioactive peptides.
Sediment contamination can be elevated in ports, harbours, and estuaries with legacies of exploitation, negatively impacting infaunal invertebrate communities. Saint John Harbour (45.25° N, 66.05° W), New Brunswick, Canada, is an active harbour strong tides a long history human activity. To examine spatial patterns sediment contamination, samples were collected between 2011 2021 from subtidal sites near potential contaminant sources. Invertebrate data the same used to investigate effects on...