A5102924089- Game Theory and Voting Systems
- Game Theory and Applications
- Auction Theory and Applications
- Multi-Criteria Decision Making
- Neuroblastoma Research and Treatments
- Gene Regulatory Network Analysis
- Particle physics theoretical and experimental studies
- Bioinformatics and Genomic Networks
- Network Traffic and Congestion Control
- Distributed and Parallel Computing Systems
- Gene expression and cancer classification
- Complexity and Algorithms in Graphs
- Particle Detector Development and Performance
- Logic, Reasoning, and Knowledge
- Software-Defined Networks and 5G
- Opinion Dynamics and Social Influence
- Optimization and Search Problems
- Advanced Optical Network Technologies
- Bayesian Modeling and Causal Inference
- Formal Methods in Verification
- Economic theories and models
- Decision-Making and Behavioral Economics
- Cytokine Signaling Pathways and Interactions
- Computational Physics and Python Applications
- Advanced Algebra and Logic
Université Paris Sciences et Lettres
2017-2024
Université Paris Dauphine-PSL
2015-2024
Centre National de la Recherche Scientifique
2015-2024
Lamsade
2013-2024
University of Bergamo
2017
Azienda Ospedaliero Universitaria Ospedali Riuniti
2011
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
2010
Istituti di Ricovero e Cura a Carattere Scientifico
2010
University of Genoa
2004-2010
National Cancer Research Institute
2006-2009
Among the novelties introduced by 5G networks, formalization of `network slice' as a resource allocation unit is an important one. In legacy resources such link bandwidth, spectrum, computing capacity are allocated independently each other. environments, network slice meant to directly serve end-to-end services, or verticals: behind demand, tenant expresses need access precise service type, under fully qualified set and requirements. The decision encompasses, therefore, combination different...
Neuroblastoma is the most common, pediatric, extra-cranial, malignant solid tumor. Despite multimodal therapeutic protocols, outcome for children with a high-risk clinical phenotype remains poor, long-term survival still less than 40%. Hereby, we evaluated potential of non-coding RNA expression to predict in high-risk, stage 4 neuroblastoma.We analyzed 481 Ultra Conserved Regions (UCRs) by reverse transcription-quantitative real-time PCR and 723 microRNAs microarrays 34 neuroblastoma...
About 50% of children with neuroblastoma (NB) show a metastatic disease and have poor prognosis. However, progression is greatly variable depends on patients' age MYCN oncogene amplification. To investigate the role in tumor aggressiveness, we performed array-CGH gene expression profiles three groups (G) NBs: G1, stage 4S patients single copy (MYCN-) tumors; G2, 4 patients, ≤ 18 months age, MYCN- tumors favorable outcome G3, Stage ≥ 19 unfavorable outcome. G1 was characterized by numerical...
Abstract BACKGROUND. Neuroblastic tumors (NTs) are largely comprised of neuroblastic (Nb) cells with various quantities Schwannian stromal (SS) cells. NTs show a variable genetic heterogeneity. NT gene expression profiles reported so far have not taken into account the cellular components. The authors genome‐wide analysis whole and microdissected Nb SS METHODS. analyzed 10 stroma‐poor (NTs‐SP) 9 stroma‐rich (NTs‐SR) by microarray technology. were isolated laser microdissection from NTs‐SP...
STUDY QUESTIONDoes storage time have any impact on the transcriptome of slowly frozen cryopreserved human metaphase II (MII) oocytes?
Metastases in the bone marrow (BM) are grim prognostic factors patients with neuroblastoma (NB). In spite of extensive analysis primary tumor cells from high- and low-risk NB patients, a characterization freshly isolated BM-infiltrating metastatic is still lacking. Our aim was to identify proteins specifically expressed by cells, that may be relevant for therapeutic purposes. Sixty-six Italian children over 18 months age, diagnosed stage 4 NB, were included study. Metastatic patients' BM...
In gene expression analysis, statistical tests for differential provide lists of candidate genes having, individually, a sufficiently low p-value. However, the interpretation each single p-value within complex systems involving several interacting is problematic. parallel, in last sixty years, game theory has been applied to political and social problems assess power agents forcing decision and, more recently, represent relevance response certain conditions. this paper we introduce Bootstrap...
Abstract Motivation: The interpretation of gene interaction in biological networks generates the need for a meaningful ranking network elements. Classical centrality analysis ranks elements according to their importance but may fail reflect power each with others. Results: We introduce new approach using coalitional games evaluate genes keeping into account genes' interactions. Shapley value is used express others and stress certain hub regulation pathways interest. main improvement this...
Does the presence of aggregates smooth endoplasmic reticulum (SERa) impact transcriptome human metaphase II (MII) oocytes?.The SERa alters molecular status oocytes.Oocytes presenting are considered dysmorphic. Oocytes with (SERa+) have been associated reduced embryological outcome and increased risk congenital anomalies, although some authors reported that SERa+ oocytes can lead to healthy newborns. The question whether or not should be discarded is still open for debate, no experimental...
Abstract ANS Collaboration is a growing Italian network of small and medium size telescopes performing spectroscopy (low resolution single dispersion, Echelle high modes) UBV R C I CCD photometry symbiotic stars novae mainly, but with interest also on other types objects like optical transients, eclipsing binaries, X-ray source counterparts on-call follow-up observations selected targets from some surveys IPHAS or RAVE. In the present form started operations in 2005, at time writing has...
Neuroblastic tumours are a group of paediatric cancers with marked morphological heterogeneity. Neuroblastoma (Schwannian stroma-poor) (NB-SP) is composed undifferentiated neuroblasts. Ganglioneuroblastoma intermixed stroma-rich) (GNBi-SR) predominantly Schwannian stromal (SS) and neuroblastic (Nb) cells. There contrasting reports suggesting that SS cells non-neoplastic. In the present study, laser capture microdissection (LCM) was employed to isolate Nb Chromosome 1p36 deletion MYCN gene...
Abstract Background At diagnosis, children with neuroblastoma (NB) present either localized or metastatic disease. Since the mechanisms responsible for BM invasion are not well known, we investigated transcriptome of resident cells from NB patients as compared to healthy children. Procedure Ninety‐two and 88 NB, respectively, 15 were included in study. recovered aspirates by immunomagnetic bead manipulation subjected genome‐wide microarray analysis. After validation an independent set...
// Marilena De Mariano 1 , Sara Stigliani 2 Stefano Moretti 3 Federica Parodi Michela Croce Cinzia Bernardi 4 Aldo Pagano 5, 6 Gian Paolo Tonini 7 Silvano Ferrini and Luca Longo UOC Bioterapie, Dipartimento di Terapie Oncologiche Integrate, IRCCS AOU San Martino-IST, Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy UOS Fisiopatologia della Riproduzione Umana, Chirurgia Generale, Specialistica ed Oncologica, Université Paris-Dauphine, PSL Research University, CNRS, Department...
We study the problem of finding a social ranking over individuals given coalitions formed by them. investigate use ceteris paribus majority principle as solution inspired from classical axioms choice theory. Faced with Condorcet-like paradox, we analyze consequences restricting domain according to an adapted version single-peakedness. conclude discussion on different interpretations incompleteness and its exploitation for defining new rankings, providing rule example.
In this paper we address the distributed cross-chain swap problem in blockchain context where multiple agents exchange assets across systems (e.g. trading Bitcoins for Litecoins or Ethers). We present a mathematical framework allowing to characterize protocols as combination of publishing and commitment phase, contracts are respectively published then committed. equilibria existing (i.e., exchanging among different blockchains). More precisely, prove that following protocol characterized by...
Abstract Background Complex human health conditions with etiological heterogeneity like Autism Spectrum Disorder (ASD) often pose a challenge for traditional genome-wide association study approaches in defining clear genotype to phenotype model. Coalitional game theory (CGT) is an exciting method that can consider the combinatorial effect of groups variants working concert produce phenotype. CGT has been applied associate likely-gene-disrupting encoded from whole genome sequence data ASD;...