A5026805560- Gastrointestinal motility and disorders
- Diet and metabolism studies
- Chronic Disease Management Strategies
- Frailty in Older Adults
- Bariatric Surgery and Outcomes
- Emergency and Acute Care Studies
- Hip and Femur Fractures
- Cardiac, Anesthesia and Surgical Outcomes
- Education, Healthcare and Sociology Research
- Social and Educational Sciences
- Regulation of Appetite and Obesity
- Congenital gastrointestinal and neural anomalies
- Cardiovascular Disease and Adiposity
- Artificial Intelligence in Healthcare
- Genetic factors in colorectal cancer
- European and International Law Studies
- Acute Kidney Injury Research
- Gut microbiota and health
- Machine Learning in Healthcare
- Hate Speech and Cyberbullying Detection
- Dermatology and Skin Diseases
- BRCA gene mutations in cancer
- Colorectal Cancer Screening and Detection
- Pelvic and Acetabular Injuries
- Multiple Myeloma Research and Treatments
University of Copenhagen
2018-2024
Copenhagen University Hospital
2020-2024
Frederiksberg Hospital
2019-2023
Novo Nordisk Foundation
2018-2021
Innlandet Hospital Trust
2017-2020
Norwegian University of Science and Technology
2017-2018
Identification of individuals at risk developing disease comorbidities represents an important task in tackling the growing personal and societal burdens associated with chronic diseases. We employed machine learning techniques to investigate what extent data from longitudinal, nationwide Danish health registers can be used predict high type 2 diabetes (T2D) comorbidities. Leveraging logistic regression-, random forest- gradient boosting models register spanning hospitalizations, drug...
Irritable bowel syndrome has been reported as more common in patients with morbid obesity than the general population. The reason for this association is unknown. aims of study were to prevalence irritable and other functional disorders obesity, search predictors syndrome. Patients opting bariatric surgery at two centers South-Eastern Norway included. Functional diagnosed according Rome III criteria. Predictors evaluated a multivariable logistic regression analysis dependent variable. A...
Zonulin is a biomarker of impaired intestinal permeability, which has been associated with various disorders. The primary aim was to study serum zonulin (s-zonulin) in individuals morbid obesity before and after conservative weight loss intervention followed by bariatric surgery. secondary aims were explore predictors s-zonulin, the associations between changes compare two treatment periods. Individuals included. Data any interventions, 6 months’ intervention, months surgery used. S-zonulin...
Background . Irritable bowel syndrome (IBS) is common in subjects with morbid obesity; the effect of weight loss programs on symptoms largely unknown. Methods This prospective cohort study explored symptoms, health scores, and biomarkers obesity during a six-month-long conservative intervention. Bowel were assessed IBS-severity scoring system (IBS-SSS) Gastrointestinal Symptom Rating Scale-IBS. Changes all variables associations between changes other analysed. Results Eighty-eight (81%...
Introduction: This study aimed to investigate the prevalence of acute kidney injury (AKI) following hip fracture surgery in geriatric patients and identify predictors for development AKI with a focus on possible preventable risk factors. Methods: In this retrospective cohort study, we reviewed electronic medical records all above 65 years age who underwent at Copenhagen University Hospital, Bispebjerg, Denmark, 2018. Acute was assessed according Kidney Disease Improving Global Outcomes...
Abstract Background Knowledge of unplanned readmission rates and prognostic factors for among older people after early discharge from emergency departments is sparse. The aims this study were to examine the rate patients short-term admission, risk including demographic factors, comorbidity admission diagnoses. Methods This cohort included all medical aged ≥65 years acutely admitted Danish hospitals between 1 January 2013 30 June 2014 surviving a hospital stay ≤24 h. Data on within days,...
Subjects with morbid obesity commonly use Non-Nutritive Sweeteners (NNS), but the health-related effects of NNS have been questioned. The objectives this study were to explore associations between theuse and health lifestyle in subjects obesity. This cross-sectional included (BMI ≥ 40 kg/m2 or ≥35 obesity-related comorbidity). Information about demographics, physical mental health, dietary habits was collected, a blood screen taken. One unit defined as 100 ml beverages 2 tablets/units for...
Abstract Background Irritable bowel syndrome (IBS) is prevalent in patients with morbid obesity. After Roux-en-Y gastric bypass (RYGB) chronic abdominal pain common, however the etiology largely unknown. We aimed to study change prevalence of IBS-like symptoms 2 years after RYGB and possible preoperative predictors such symptoms. Secondly, evaluate changes constipation diarrhea, Health related quality life (HRQoL). Methods Patients obesity were included at two centers South-Eastern Norway....
Abstract Background The mortality of older patients after early discharge from hospitals is sparsely described. Information on factors associated with can help identify high-risk who may benefit preventive interventions. aim this study was to examine whether demographic factors, comorbidity and admission diagnoses are predictors 30-day among acutely admitted discharged within 24 h admission. Methods All medical aged ≥65 years Danish between 1 January 2013 30 June 2014 surviving a hospital...
Abstract C-reactive protein, neopterin and lactoferrin are biomarkers of atherosclerotic disease. We aimed to assess changes in these after conservative surgical weight loss interventions individuals with morbid obesity, evaluate associations between biomarker body mass index HbA1c, study the biomarkers. were measured before intervention bariatric surgery. Data analysed mixed models. 137 (mean age 43 years) included. Body decreased from 42.1 kg/m 2 38.9 intervention, further 30.5 All...
Baker's/brewer's yeast, Saccharomyces cerevisiae, has been used as an alternative to antibiotic growth promoters improve performance in animals. In humans, cerevisiae is among the most commonly detected fungi fecal samples and likely originates from food. Recently, association between anti-Saccharomyces antibodies (ASCA) obesity humans was suggested, but cause of elevated ASCA levels not clear. Our aim study morbidly obese subjects explore potential associations with anthropometrics, diet,...
Biomarkers for irritable bowel syndrome (IBS) are demanded. An altered faecal microbiome has been reported in subjects with IBS and could be a valuable biomarker. This study evaluated the diagnostic properties of new test dysbiosis, designed to distinguish from healthy volunteers compared prevalence rates dysbiosis related morbid obesity. Subjects without obesity were included. The microbiota was assessed GA-mapTM Dysbiosis Test (Genetic Analysis AS, Oslo, Norway). result given as (yes/no)....
Faecal dysbiosis associated with the use of metformin has been conceived as a favourable ("good") and that intake non-nutritive sweeteners (NNS) unfavourable ("bad"). The study aimed to construct an alternative index (ADI) for separation dysbioses into "good" "bad", validate ADI. Subjects morbid obesity were included. Use NNS drugs noted, IBS was classified according Rome III criteria severity measured Irritable bowel scoring system (IBSSS). tested GA-Map ™ Dysbiosis test (Genetic Analysis...
Background Weight loss after bariatric surgery varies widely between individuals, partly due to genetic differences. In addition, determinants of abdominal obesity have been shown attenuate weight dietary intervention with special attention paid the rs1358980-T risk allele in VEGFA locus. Here we aimed test if updated scores (GRSs) for adiposity measures and are linked following gastric bypass surgery. Methods Five hundred seventy six patients morbid underwent Roux-en-Y bypass. A GRS BMI a...
ABSTRACT Identification of individuals at risk developing disease comorbidities represents an important task in tackling the growing personal and societal burdens associated with chronic diseases. We employed machine learning techniques to investigate what extent data from longitudinal, nationwide Danish health registers can be used predict high type 2 diabetes (T2D) comorbidities. Based on register spanning hospitalizations, drug prescriptions contacts primary care contractors >200,000...
Surgical treatment of hip fractures within 24-48 hours decreases morbidity and mortality, but goals for early surgery have not been widely achieved so far. The primary aim this study was to investigate the feasibility implementation a call, secondary effect call on time pre-operative preparation compared historical control cohort.From March 4, 2019 until June 30, 2019, admission patients at Copenhagen University Hospital, Bispebjerg, Denmark, with suspected fracture triggered an acute call....