A5063416292- Pharmaceutical Practices and Patient Outcomes
- Acute Myocardial Infarction Research
- Heart Failure Treatment and Management
- Medication Adherence and Compliance
- Health Systems, Economic Evaluations, Quality of Life
- Chronic Disease Management Strategies
- Acute Ischemic Stroke Management
- Blood Pressure and Hypertension Studies
- Cardiac Imaging and Diagnostics
- Primary Care and Health Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Pharmaceutical Economics and Policy
- Atrial Fibrillation Management and Outcomes
- Healthcare Policy and Management
- Infective Endocarditis Diagnosis and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Global Health Workforce Issues
- Emergency and Acute Care Studies
- Cardiac Valve Diseases and Treatments
- Medical Coding and Health Information
- Coronary Interventions and Diagnostics
- Cardiac Health and Mental Health
- Health disparities and outcomes
- Food Allergy and Anaphylaxis Research
- Cardiac Arrest and Resuscitation
The University of Western Australia
2016-2025
The University of Melbourne
2020-2022
Royal Perth Hospital
1995-2022
Institute of Population and Public Health
2021
Monash University
2010-2020
Griffith University
2020
The University of Sydney
2020
Florey Institute of Neuroscience and Mental Health
2020
Monash Health
2020
The George Institute for Global Health
2020
Background Switching from a conventional to high-sensitivity cardiac troponin (hs-cTn) assay enables detection of smaller amounts myocardial damage, but the clinical benefit is unclear. We investigated whether switching hs-cTnI with sex-specific 99th centile diagnostic threshold was associated lower 1-year death or new infarction (MI) in patients suspected acute coronary syndrome (ACS). Methods This pre–post study included nine tertiary hospitals Australia. During pre-hs-cTn period, all used...
<b>Objectives</b> To identify factors that predict repeat admission to hospital for adverse drug reactions (ADRs) in older adults. <b>Design</b> Population based retrospective cohort study. <b>Setting</b> All public and private hospitals Western Australia. <b>Participants</b> 28 548 patients aged ≥60 years with an ADR during 1980-2000 followed three using the Australian data linkage system. <b>Results</b> 5056 (17.7%) had a ADR. Repeat ADRs were associated sex (hazard ratio 1.08, 95%...
Background— Survivors of nonfatal coronary heart disease (CHD) can reduce their risk further events by various preventive interventions. The impact such measures as delivered over 11 years, on population rates subsequent major CHD events, has not been extensively studied. This study determined trends in the prevalence clinically manifest and proportion that occur this population. Methods Results— A longitudinal person-based event-linked file extracted from State Hospital Morbidity Data Death...
Background Advances in treatment for acute myocardial infarction ( AMI ) are likely to have had a beneficial impact on the incidence of and deaths attributable heart failure HF complicating , although limited data available support this contention. Methods Results W estern A ustralian linked administrative health were used identify 20 812 consecutive patients, aged 40 84 years, without prior hospitalized with an index (first) between 1996 2007. We assessed temporal adjusted odds ratio/hazard...
Background: Predisposition to adverse drug events with advancing age has led the development of lists potentially inappropriate medications (PIMs) be avoided in elderly, such as Beers Criteria. The prevalence been studied widely, but it is still unclear whether PIM use predictive older people. Objectives: To examine potential associations between exposure PIMs from general list and unplanned hospitalizations elderly Western Australians. Methods: Using an enhanced case-time-control design...
Abstract Aims Machine learning (ML) is widely believed to be able learn complex hidden interactions from the data and has potential in predicting events such as heart failure (HF) readmission death. Recent studies have revealed conflicting results likely due take into account class imbalance problem commonly seen with medical data. We developed a new ML approach predict 30 day HF or death compared performance of this model other used prediction models. Methods identified all Western...
Background In 2018, the World Health Organization prioritized control of acute rheumatic fever (ARF) and heart disease (RHD), including surveillance. We developed strategies for estimating contemporary ARF/RHD incidence prevalence in Australia (2015-2017) by age group, sex, region Indigenous non-Indigenous Australians based on innovative, direct methods. Methods Results This population-based study used linked administrative data from 5 Australian jurisdictions. A cohort ARF (age <45 years)...
<b>Objective</b> To examine trends in long term survival patients alive 28 days after myocardial infarction and the impact of evidence based medical treatments coronary revascularisation during or near event. <b>Design</b> Population cohort with 12 year follow-up. <b>Setting</b> Perth, Australia. <b>Participants</b> 4451 consecutive a definite acute according to World Health Organization MONICA (monitoring determinants cardiovascular disease) criteria admitted hospital 1984-7, 1988-90,...
Health care disparity is a public health challenge. We compared the prevalence of diabetes, quality and outcomes between mental clients (MHCs) non-MHCs. This was population-based longitudinal study 139,208 MHCs 294,180 matched non-MHCs in Western Australia (WA) from 1990 to 2006, using linked data registry, electoral roll registrations, hospital admissions, emergency department attendances, deaths, Medicare pharmaceutical benefits claims. Diabetes identified diagnoses, prescriptions...
Background The prediction of readmission or death after a hospital discharge for heart failure (HF) remains major challenge. Modern healthcare systems, electronic health records, and machine learning (ML) techniques allow us to mine data select the most significant variables (allowing reduction in number variables) without compromising performance models used death. Moreover, ML methods based on transformation may potentially further improve performance. Objective To use determine relevant...
Abstract This study explores the effectiveness of Explainable Artificial Intelligence (XAI) for predicting suicide risk from medical tabular data. Given common challenge limited datasets in health-related Machine Learning (ML) applications, we use data augmentation tandem with ML to enhance identification individuals at high suicide. We SHapley Additive exPlanations (SHAP) XAI and traditional correlation analysis rank feature importance, pinpointing primary factors influencing preventive...
C plays a critical role in the hyperacute rejection (HAR) of discordant xenografts (Xg), but relative contribution early vs late components is unknown. In this study, genetic differences C6 activity were correlated with HAR guinea pig cardiac Xg by rat. Seven rat strains tested for activity. Six (PVG.R1 (R1), PVG.1A (1A), DA, W/F, F344, LEW) had readily detectable total and alternative pathways. Some PVG rats also adequate [PVG (C+)] others (C-)] profound deficiency. All (n = 35) rejected...
Background Hepcidin, a key regulator of iron homeostasis, is increased in response to inflammation and some infections, but the vivo role hepcidin, particularly children with deficiency anemia (IDA) unclear. We investigated relationships between cytokines status pediatric population high prevalence both co-morbid infections. Methodology/Principal Findings African refugee <16 years were consecutively recruited at initial post-resettlement health check 181 meeting inclusion criteria. Data on...
BACKGROUND- The incidence of myocardial infarction has declined during the past 4 decades in many populations. However, there are limited population data measuring trends acute coronary syndromes (ACS). We therefore examined temporal hospitalized ACS by age and sex a population-based cohort. METHODS AND RESULTS- Western Australian Data Linkage System, repository linked administrative health data, was used to identify 29 421 incident hospitalizations between 1996 2007. Poisson log-linear...
Background and Purpose: Although a target of 80% medication adherence is commonly cited, it unclear whether greater improves survival after stroke or transient ischemic attack (TIA). We investigated associations between during the first year postdischarge, mortality up to 3 years, provide evidence-based targets for adherence. Methods: Retrospective cohort study 1-year survivors first-ever TIA, aged ≥18 from Australian Stroke Clinical Registry (July 2010–June 2014) linked with nationwide...