A5003587075- Astrophysical Phenomena and Observations
- Astrophysics and Cosmic Phenomena
- Astrophysics and Star Formation Studies
- Dialysis and Renal Disease Management
- Ion Transport and Channel Regulation
- Pulsars and Gravitational Waves Research
- Gamma-ray bursts and supernovae
- Renal function and acid-base balance
- Chronic Kidney Disease and Diabetes
- Heart Failure Treatment and Management
- Potassium and Related Disorders
- Stellar, planetary, and galactic studies
- Atomic and Molecular Physics
- Eosinophilic Esophagitis
- Neutrino Physics Research
- Blood Pressure and Hypertension Studies
- Renal and related cancers
- Electrolyte and hormonal disorders
- Eosinophilic Disorders and Syndromes
- Renal Diseases and Glomerulopathies
- Astro and Planetary Science
- Advanced X-ray Imaging Techniques
- Acute Kidney Injury Research
- Effects of Vibration on Health
- Renin-Angiotensin System Studies
Osaka University
2020-2025
University of Tsukuba
2019-2025
Yamagata University
2023
Osaka National Hospital
2020-2022
Kyoto University
2019
National Astronomical Observatory of Japan
2017-2018
Chiba University
2012-2014
Graduate School USA
2014
Key Points Restarting renin-angiotensin system inhibitor after discontinuation was associated with a lower risk of kidney outcomes and mortality but not related to hyperkalemia. Our findings support proactive approach restarting among patients CKD. Background While inhibitors (RASi) have been the mainstream treatment for CKD, they are often discontinued because adverse effects such as hyperkalemia AKI. It is unknown whether RASi improves clinical outcomes. Methods Using Osaka Consortium...
We present a new magnetohydrodynamic (MHD) simulation code with the aim of providing accurate numerical solutions to astrophysical phenomena where discontinuities, shock waves, and turbulence are inherently important. The implements HLLD approximate Riemann solver, fifth-order-monotonicity-preserving interpolation (MP5) scheme, hyperbolic divergence cleaning method for magnetic field. This choice schemes significantly improved accuracy stability, saved computational costs in multidimensional...
Real-world evidence about mineralocorticoid receptor antagonist (MRA) use has been limited in chronic kidney disease, particularly regarding its association with hard renal outcomes.In this retrospective cohort study, adult disease outpatients referred to the department of nephrology at an academic hospital between January 2005 and December 2018 were analyzed. The main inclusion criteria estimated glomerular filtration rate ≥10 <60 mL/min per 1.73 m2 follow-up ≥90 days. exposure interest was...
Abstract We perform global three-dimensional (3D) radiation-hydrodynamic (RHD) simulations of outflow from supercritical accretion flow around a 10 M⊙ black hole. only solve the part, starting axisymmetric 2D simulation data in nearly steady state but with small perturbations sinusoidal form being added azimuthal direction. The mass rate onto hole is ∼102LE/c2 underlying data, and ∼10 LE/c2 (with LE c Eddington luminosity speed light, respectively). first confirm emergence clumpy outflow,...
We encountered a family with hereditary renal failure, medullary cysts, pancreatic hypoplasia, hypomagnesemia, liver enzyme abnormalities, and diabetes mellitus (DM). identified novel heterozygous variant of HNF1B (NM_000458.4:c.791dup, p.L264Ffs*30) using whole-exome sequencing genomic DNA samples from this family. This is located in the DNA-binding domain protein produces truncated de novo sequence, suggesting that changes binding to or causes nonsense-mediated mRNA decay. Based on...
Inhibiting tubular urate reabsorption may protect the kidney from urate-induced injury. However, this approach promote intratubular uric acid crystallization, especially in acidified urine, which could be toxic to kidney. To assess how handling affects outcomes, we conducted a retrospective cohort study including 1042 patients with estimated glomerular filtration rates (eGFR) of 15-60 mL/min/1.73 m
We study the effects of magnetic field on dynamics non-rotating stellar cores by performing two-dimensional (2D), magnetohydrodynamics (MHD) simulations. To this end, we have updated our neutrino-radiation-hydrodynamics supernova code to include MHD employing a divergence cleaning method with both careful treatments finite volume and area reconstructions. By changing initial strength field, evolution $15.0$, $18.4$ $27.0$ $M_\odot$ presupernova progenitors is investigated. An intriguing...
Abstract We perform general relativistic radiation magnetohydrodynamics simulations of super-Eddington accretion flows around a neutron star with dipole magnetic field for modeling the Galactic ultraluminous X-ray source exhibiting pulsations, Swift J0243.6+6124. Our show columns near poles, disk outside magnetosphere, and outflows from disk. It is revealed that effectively optically thick outflows, consistent observed thermal emission at ∼10 7 K, are generated if mass rate much higher than...
Background Interstitial eosinophilic aggregates are observed in various kidney diseases, but their clinical implications remain unknown. We assessed the association between interstitial and outcomes further analyzed blood eosinophil count, as a surrogate for aggregates, risk of failure patients with advanced CKD. Methods datasets from two retrospective cohort studies: ( 1 ) biopsy including 563 who underwent native at Osaka University Hospital 2009 2021 2 CKD 2877 an eGFR 10–60 ml/min per...
Abstract We perform 2.5-dimensional general relativistic radiation magnetohydrodynamics simulations of black hole accretion disks and disk winds in the range mass rate from 0.1 to 10 4.5 times Eddington limit. In this paper, we compare results INAZUMA code, which frequency-integrated time-dependent transfer equation is solved order evaluate tensor, with those first momentum (M1) approximation method. both methods, appear, there no remarkable difference rate, outflow or luminosity. However,...
Abstract By performing two-dimensional axisymmetric general relativistic radiation magnetohydrodynamics simulations with spin parameter a * varying from −0.9 to 0.9, we investigate the dependence on black hole of energy flow supercritical accretion disk around stellar mass hole. It is found that optically and geometrically thick disks form near equatorial plane, part matter launched surface in all models. The gas ejection mainly driven by radiative force, but magnetic force cannot be...
Abstract We develop a general relativistic radiation magnetohydrodynamics (GR-RMHD) code inazuma in which the time-dependent transfer equation (frequency-integrated Boltzmann equation) is solved curved spacetime. The Eddington tensor derived from specific intensity, and we solve zeroth first moment equations order to update fields. Therefore, our can field around compact objects more appropriately than an approximation method like M1 closure scheme. numerical scheme of same as that previous...
Background Gait abnormality is a serious problem among hemodialysis patients. Whole-body vibration simple exercise that induces sustained muscular contractions through mechanical vibrations. This training improved gait ability in older adults. We aimed to investigate the effect of whole-body on balance and Methods conducted 12-week, open-label, multicenter, randomized controlled trial 98 patients, who were aged ≥65 years, from three dialysis centers Japan. Those had difficulty walking alone...
The formation mechanism of the jet-aligned CO clouds found by NANTEN observations is studied magnetohydrodynamical (MHD) simulations taking into account cooling interstellar medium. Motivated association with enhancement H i gas density, we carried out MHD propagation a supersonic jet injected dense gas. We that compressed bow shock ahead cooled down growth instability triggered density enhancement. As result, cold sheath formed around interface between and radial speed cold, in few km s−1...
We have discovered two molecular features at radial velocities of −35 km s−1 and 0 toward the infrared Double Helix Nebula (DHN) in Galactic center with NANTEN2. The show good spatial correspondence DHN. also found elongated ridges these distributed vertically to plane over 08. are linked by broad velocity likely connected physically each other. ratio between 12CO J = 2–1 1–0 transitions is 0.8 which larger than average value 0.5 foreground gas, suggesting center. An examination K band...
Although ultraluminous X-ray pulsars (ULXPs) are believed to be powered by super-Eddington accretion onto a magnetized neutron star (NS), the detailed structures of inflow-outflow and magnetic fields still not well understood. We perform general relativistic radiation magnetohydrodynamics (GR-RMHD) simulations flows NS with dipole and/or quadrupole fields. Our results show that an disk optically thick outflows form outside magnetospheric radius, while inflows aligned field lines appear...
Metabolic acidosis is one of the most common complications chronic kidney disease (CKD). It associated with progression CKD, and many other functional impairments. Until recently, only serum bicarbonate levels have been used to evaluate acid-base changes in patients reduced function. However, recent emerging evidence suggests that nephrologists should reevaluate clinical approach for diagnosing metabolic CKD based on two perspectives; pH anion gap. Biochemistry physiology textbooks clearly...
Studies examining associations between metabolic acidosis and cardiovascular events in chronic kidney disease (CKD) have shown conflicting results not differentiated normal anion gap (hyperchloremic) high acidosis. We aimed to examine the impact of acidosis, separately, on risk among patients with CKD.This retrospective cohort study included 1168 an estimated glomerular filtration rate (eGFR) 10-60 mL/min/1.73 m2 available data gap. analyzed association time-updated (anion ≥9.2) using...
In astrophysical jets observed in active galactic nuclei and microquasars, the energy exchange rate by Coulomb collision is insufficient for thermal equilibrium between ions electrons. Therefore, it necessary to consider difference ion temperature electron temperature. We present results of two-temperature magnetohydrodynamics(MHD) simulations demonstrate effects coupling. It assumed that dissipation heats only ions. find temperatures are separated through shocks. Since entropy increased at...
We have made new CO observations of two molecular clouds, which we call "jet" and "arc" toward the stellar cluster Westerlund 2 TeV γ-ray source HESS J1023−575. The jet cloud shows a linear structure from position on east. In addition, found counter west. arc crescent shape in west A sign star formation is at edge gives constraint age to be ∼Myr. An analysis with multi transitions temperature as high 20 K few places cloud, suggesting that some additional heating may operating locally. images...