A5085346416- Lipid Membrane Structure and Behavior
- Systemic Lupus Erythematosus Research
- Immune Cell Function and Interaction
- Reproductive System and Pregnancy
- Circadian rhythm and melatonin
- Mesenchymal stem cell research
- Connexins and lens biology
- Tissue Engineering and Regenerative Medicine
- Sperm and Testicular Function
- Luminescence and Fluorescent Materials
- Intraperitoneal and Appendiceal Malignancies
- Nanoparticle-Based Drug Delivery
- Polymer Nanocomposite Synthesis and Irradiation
- Extracellular vesicles in disease
- CAR-T cell therapy research
- Endometriosis Research and Treatment
- Heat shock proteins research
- Cancer Treatment and Pharmacology
- Reproductive biology and impacts on aquatic species
- T-cell and B-cell Immunology
- Retinoids in leukemia and cellular processes
- Sphingolipid Metabolism and Signaling
- Cellular transport and secretion
- Erythrocyte Function and Pathophysiology
- Neuroscience and Neuropharmacology Research
Medical University of Sofia
2017-2025
Sofia University "St. Kliment Ohridski"
2014-2021
Objective: Drug loading into nanocarriers is used to facilitate drug delivery target cells and organs. We have previously reported a change in cellular localization of epirubicin after poly(butyl cyanoacrylate) (PBCA) nanoparticles. aimed further investigate the altered responses described formulation.Materials methods: HeLa were treated with epirubicin-loaded PBCA nanoparticles prepared by pre-polymerization method. A systematic study was performed evaluate formulation cytotoxicity....
Human bestrophin-1 protein (hBest1) is a transmembrane channel associated with the calcium-dependent transport of chloride ions in retinal pigment epithelium as well glutamate and GABA nerve cells. Interactions between hBest1, sphingomyelins, phosphatidylcholines cholesterol are crucial for hBest1 association cell membrane domains its biological functions. As plays key role formation lipid rafts, motional ordering lipids modeling/remodeling lateral structure, we examined effect different...
There is a distinct group among the patients with unexplained infertility who are found to have enhanced humoral immune response. Recent studies focus on expression of stress proteins being an important factor in stages gametogenesis, fertilization, implantation, early embryonic development and pregnancy. Increased response against them was tissues exposed stress. not enough data linking immunity α-crystallins endocrine diseases. The aim this work study anti-α-crystallin antibodies...
Natural killer (NK) cells can discriminate between normal and cancer are known to directly recognize kill malignant or induce apoptosis. Thus, activation of NK is considered as a promising strategy for treatment. However, clinical application has been somewhat limited because difficulties in the preparation sufficient number highly cytotoxic/activated vitro. We used cytokine stimulation provide suitable environment (activating receptor-ligand interactions) expansion cells. This method...
We studied the effects of increased cholesterol on morphology ejaculated human spermatozoa by manipulating content medium.The results, surprisingly, showed an increase head and neck abnormalities similar to that caused hydrogen peroxide, a known source oxidative damage.The highest rate was observed in samples exposed both substances, showing did not protect from damaging action H 2 O , maybe even exacerbated it.We could hypothesize conferring excessive rigidity sperm cell membrane beyond...
Natural killer (NK) cells are effector lymphocytes of innate immunity needed to protect against stressed and destroy tumor virus-infected cells. These play an important role in the immune surveillance malignant cells, preventing their uncontrolled growth. recognize target directly through receptors, which bind various determinants on surface cell. The receptor-ligand (secretory or membrane-bound) interaction between NK determines NK’s cell activity. use monoclonal antibodies therapy has...