A5089612398- Lipid Membrane Structure and Behavior
- Sphingolipid Metabolism and Signaling
- Surfactants and Colloidal Systems
- Erythrocyte Function and Pathophysiology
- Cellular transport and secretion
- Force Microscopy Techniques and Applications
- Alzheimer's disease research and treatments
- Autophagy in Disease and Therapy
- Protein Structure and Dynamics
- Adipose Tissue and Metabolism
- Advancements in Transdermal Drug Delivery
- Nanoparticles: synthesis and applications
- Supramolecular Self-Assembly in Materials
- RNA Interference and Gene Delivery
- Glycosylation and Glycoproteins Research
- Sirtuins and Resveratrol in Medicine
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and biological activity
- Calcium signaling and nucleotide metabolism
- Graphene and Nanomaterials Applications
- Bioactive Compounds and Antitumor Agents
- Endoplasmic Reticulum Stress and Disease
- Lipid metabolism and biosynthesis
- Schizophrenia research and treatment
- Nanocomposite Films for Food Packaging
Bulgarian Academy of Sciences
2014-2025
Institute of Biophysics and Biomedical Engineering
2014-2025
Institute of Biophysics
2009-2010
Resurrection plant species are a group of higher plants whose vegetative tissues able to withstand long periods almost full desiccation and recover quickly upon rewatering. Apart from being model system for studying tolerance, resurrection appear be valuable source metabolites, with various areas application. A significant number papers have been published in recent years respect the extraction application bioactive compounds test systems. Promising results obtained antioxidative antiaging...
7-Dehydrocholesterol, an immediate metabolic predecessor of cholesterol, can accumulate in tissues due to some abnormalities, causing array symptoms known as Smith–Lemli–Opitz syndrome. Enrichment cellular membranes with 7-dehydrocholesterol interferes normal cell-signaling processes, which involve interaction between rafts and formation the so-called signaling platforms. In model membranes, cholesterol-based ordered domains usually merge upon contact. According our experimental data,...
In the last decades, numerous dendrimers with a variety of potential biomedical applications have been developed and investigated. The aim present study was to evaluate molecular mechanisms interaction between two proven antibacterial activity (4-N,N-dimethylamino-1,8-naphthalimide (Dab) 3-bromo-Dab (Dab-Br)) POPC (1-palmitoyl-2-oleoylphosphatidylcholine) model membranes (monolayers liposomes). pressure-area isotherms compressional modulus monolayers revealed that Dab is likely penetrate...
Resveratrol is a naturally occurring polyphenol which has various beneficial effects, such as anti-inflammatory, anti-tumor, anti-aging, antioxidant, and neuroprotective among others. The anti-cancer activity of resveratrol been related to alterations in sphingolipid metabolism. We analyzed the effect on enzymes responsible for accumulation two sphingolipids with highest functional activity-apoptosis promoting ceramide (CER) proliferation-stimulating sphingosine-1-phosphate (S1P)-in human...
Antipsychotics (APs) are used in the treatment of severe mental disorders. Their mechanism action involves interaction with multiple brain targets, notably dopamine D2 receptors (D2R), where they compete dopamine. Due to their lipophilic nature, APs also partition and accumulate lipid membranes, particularly around D2R synaptic vesicles. When intercalated into slowly act as a reservoir, allowing rapid release on demand modulate neurotransmitter signaling. They modify physicochemical...
Nanotechnology offers alternative approaches to the discovery of anticancer drugs. Hydrophobic bioactive components can be included in cores amphiphilic nanocarriers, which leads formation a water-dispersible product with improved bioavailability, facilitated excretion, and reduced systemic toxicity treated organisms. This study was aimed at polymer loaded drug precursor podophylotoxin (PPT) or PPT-containing juniper leaf extracts, seeking their antineoplastic activity A-431 epidermoid...
The phase behavior of egg sphingomyelin (ESM) mixtures with cholesterol or 7-dehydrocholesterol (7-DHC) has been investigated by independent methods: fluorescence microscopy, X-ray diffraction, and electron spin resonance spectroscopy. In giant vesicles, cholesterol-enriched domains appeared as large clearly delineated assigned to a liquid-ordered (Lo) phase. containing 7-DHC were smaller had more diffuse boundaries. Separation gel examination pure coexisting sterol-enriched was observed at...
Background/Aim: A number of biologically active substances were proved as an alternative to conventional anticancer medicines. The aim the study is in vitro investigation activity mono- and di-Rhamnolipids (RL-1 RL-2) against human breast cancer. Additionally, combination with Cisplatin was analyzed. Materials Methods: Breast cell lines (MCF-10A, MCF-7 MDA-MB-231) treated RLs Cisplatin. viability analyzed using MTT assay, autophagy performed via acridine orange staining. Results: In contrast...
Multiple sclerosis (MS) is an autoimmune, inflammatory, degenerative disease of the central nervous system. Changes in lipid metabolism have been suggested to play important roles MS pathophysiology and progression. In this work we analyzed composition sphingolipid-catabolizing enzymes erythrocytes plasma from patients healthy controls. We observed reduction sphingomyelin (SM) elevation its products-ceramide (CER) shingosine (SPH). These changes were supported by detected up-regulation...
The Alzheimer amyloid β-peptide binds to the liquid-disordered lipid phase and modulates nanodomain–microdomain size dynamics of raft-mimicking Lo domains in model membranes containing ganglioside GM1.