A5051523033- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Cancer-related gene regulation
- Celiac Disease Research and Management
- Microscopic Colitis
- Gastrointestinal disorders and treatments
- Eosinophilic Esophagitis
- Microbial Metabolites in Food Biotechnology
- Foreign Body Medical Cases
- Intestinal Malrotation and Obstruction Disorders
- Esophageal and GI Pathology
- Tracheal and airway disorders
- Genetic Neurodegenerative Diseases
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal motility and disorders
- Genomics and Chromatin Dynamics
- Lung Cancer Research Studies
- Genetic Syndromes and Imprinting
- Oral health in cancer treatment
- Pediatric Pain Management Techniques
- Digestive system and related health
- Infant Health and Development
- Microbial metabolism and enzyme function
- Child Development and Digital Technology
- Health Literacy and Information Accessibility
Children's Hospital of Philadelphia
2009-2025
University of Pennsylvania
2009-2025
Columbia University
2017
Children's Hospital at Montefiore
2014
Montefiore Medical Center
2014
Albert Einstein College of Medicine
2014
Mapping of allele-specific DNA methylation (ASM) can be a post-GWAS strategy for localizing regulatory sequence polymorphisms (rSNPs). The advantages this approach, and the mechanisms underlying ASM in normal neoplastic cells, remain to clarified.
The association of celiac disease (CD) in type 1 diabetes mellitus (T1DM) is well-established, yet variation exists screening practices. This study measures the accuracy early with tissue transglutaminase Immunoglobulin A (TTG-IgA) and endomysial antibody (EMA) newly diagnosed T1DM. a retrospective children T1DM between 2013 2019 CD follow-up. Data elements included anthropometrics, serologies, blood pH, bicarbonate, Hemoglobin A1c. Celiac serologies were analyzed using chi-square receiver...
Determine contemporary rates of early mucosal recovery in children with celiac disease (CeD). Multicenter retrospective cohort study Canada and the United States. Children diagnosed CeD between 2016 2021 who underwent a follow-up biopsy within 15 months diagnosis were included. Overall, 96/130 (74%) had recovery, including 48% (12/25) assessed 3 months. Musculoskeletal symptoms at only clinical characteristic associated persistent enteropathy. While can occur months, more than quarter...
Dysarthria in Friedreich Ataxia (FA) is difficult to quantify. This study evaluated a series of performance measures for speech 22 patients with genetically confirmed FA and 16 age-matched controls. Tests included the PATA examination, PATAKA Oral Motor component Boston Aphasia Cookie Theft description task, Assessment Intelligibility Dysarthric Speech. All measures, except theft demonstrated significantly lower scores when compared controls correlated disease progression. Thus, four five...
While guidelines exist for the diagnosis and management of pediatric celiac disease (CeD), current practices in North America are not well-described. This study aimed to explore practice patterns identify gaps direct future clinical, training research initiatives.
Objectives: Patients with Trisomy 21 (T21) commonly have gastrointestinal symptoms and diseases that prompt evaluation esophagogastroduodenoscopy (EGD). Our objective is to characterize duodenal histological abnormalities in these patients when undergoing EGD. A secondary aim explore associations of histologic findings different therapies. Methods: 30 years old or younger T21 who underwent EGD from 2000 2020 at 6 hospitals were included this retrospective cohort study. Duodenal biopsies...
Abstract Background Mapping of allele-specific DNA methylation (ASM) can be a post-GWAS strategy for localizing regulatory sequence polymorphisms (rSNPs). However, the advantages this approach, and mechanisms underlying ASM in normal neoplastic cells, remain to clarified. Results We performed whole genome methyl-seq on diverse cells tissues three types cancers (multiple myeloma, lymphoma, glioblastoma multiforme). After excluding imprinting, data pinpointed 15,114 high-confidence...
The aim of the study was to determine correlation between duodenal mucosal biopsies and tissue transglutaminase immunoglobulin A (tTG-IgA) levels in pediatric patients with biopsy-confirmed celiac disease (CD) eosinophilic gastrointestinal disorders (EGID) who have had repeat after initiating a gluten-free diet.A retrospective chart review performed children CD EGID seen at Children's Hospital Philadelphia 2003 2018. Data collected included biopsy pathology, serology including tTG-IgA,...