A5012371253- Traumatic Brain Injury and Neurovascular Disturbances
- Optical Imaging and Spectroscopy Techniques
- S100 Proteins and Annexins
- Cerebrospinal fluid and hydrocephalus
- Sepsis Diagnosis and Treatment
- Amyotrophic Lateral Sclerosis Research
- Neurosurgical Procedures and Complications
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Non-Invasive Vital Sign Monitoring
- Acute Ischemic Stroke Management
- Neonatal Respiratory Health Research
University of Cambridge
2023-2025
Addenbrooke's Hospital
2025
University of Cape Town
2023
Red Cross War Memorial Children's Hospital
2023
OBJECTIVES: To examine cerebrovascular pressure reactivity index (PRx) in a large cohort of children with severe traumatic brain injury (sTBI) association physiologic variables and outcome. DESIGN: Retrospective observational study. SETTING: Red Cross War Memorial Children’s Hospital Cape Town, South Africa. PATIENTS: Pediatric (≤ 14 yr old) sTBI patients intracranial (ICP) monitoring (postresuscitation Glasgow Coma Score [Glasgow Scale (GCS)] ≤ 8). MEASUREMENTS AND MAIN RESULTS: Data were...
Targeting single monitoring modalities such as intracranial pressure (ICP) or cerebral perfusion alone has shown to be insufficient in improving outcome after traumatic brain injury (TBI). Multimodality (MMM) allows for a more complete description of function and individualized management. Transcranial Doppler (TCD) represents the gold standard continuous blood flow velocity assessment, but requires high levels skill time. In TBI, practical aspects conducting extended TCD sessions have yet evaluated.
A bstract Cerebrovascular autoregulation (CAR) maintains stable cerebral perfusion by adjusting arteriole diameters in response to slow pressure fluctuations. Various CAR correlation coefficients—PRx (based on intracranial pressure—ICP), Mx transcranial doppler—TCD), and COx/THx near‐infrared spectroscopy—NIRS)—are used interchangeably despite fundamental differences. 566 hours of ICP, NIRS, TCD data from 38 traumatic brain injury (TBI) patients were assessed. The intercorrelation between...
Cerebral autoregulation (CA) dysfunction is a key complication following brain injury. CA assessment using near-infrared spectroscopy (NIRS) offers promising alternative to the current non-invasive standard, cerebral blood flow velocity (CBFV) measured with transcranial Doppler. Can autoregulatory slow waves (frequency range 0.005–0.05 Hz) associated spontaneous and induced changes in ABP healthy volunteers be detected by parameters Masimo O3 NIRS device? ABP, CBFV were 10 at baseline during...
Abstract Background Microglia play crucial roles in maintaining neuronal homeostasis but have been implicated contributing to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). However, the role of microglia ALS/FTD remains incompletely understood. Methods Here, we generated highly enriched cultures VCP mutant derived from human induced pluripotent stem cells (hiPSCs) investigate their cell autonomous non-cell ALS pathogenesis. We used RNA-sequencing, proteomics...