A5027028267- African history and culture studies
- South African History and Culture
- African studies and sociopolitical issues
- CAR-T cell therapy research
- Legal Issues in South Africa
- Long-Term Effects of COVID-19
- dental development and anomalies
- Inflammasome and immune disorders
- Global Maritime and Colonial Histories
- Immunotherapy and Immune Responses
- Dental Radiography and Imaging
- Oral and Maxillofacial Pathology
- Mediterranean and Iberian flora and fauna
- Archaeology and Historical Studies
- Mitochondrial Function and Pathology
- Dental Education, Practice, Research
- African history and culture analysis
- Urban and Rural Development Challenges
- SARS-CoV-2 and COVID-19 Research
- Travel Writing and Literature
- Immune responses and vaccinations
- Engineering Technology and Methodologies
- Oral and Craniofacial Lesions
- Cancer Immunotherapy and Biomarkers
- Biosimilars and Bioanalytical Methods
Fred Hutch Cancer Center
2021-2024
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa
2022-2023
University of Oxford
2008-2023
Cancer Research Center
2022
Oxford Centre for Mission Studies
2009-2017
African Studies Centre
2009-2014
University of Zambia
1984-1996
Long COVID or post-acute sequelae of SARS-CoV-2 (PASC) is a clinical syndrome featuring diverse symptoms that can persist for months following acute infection. The aetiologies may include persistent inflammation, unresolved tissue damage delayed clearance viral protein RNA, but the biological differences they represent are not fully understood. Here we evaluate serum proteome in samples, longitudinally collected from 55 PASC individuals with lasting ≥60 days after onset infection, comparison...
SARS-CoV-2 has infected over 200 million and caused more than 4 deaths to date. Most individuals (>80%) have mild symptoms recover in the outpatient setting, but detailed studies of immune responses focused primarily on moderate severe COVID-19. We deeply profiled longitudinal response with COVID-19 beginning early time points post-infection (1-15 days) proceeding through convalescence >100 days after symptom onset. correlated data from single cell analyses peripheral blood cells, serum...
Zambia has long been recognised as one of the most urbanised countries in Africa. The major theme social scientific study country since development Copperbelt late 1920s relationship between towns and rural areas. This subject academic political debate for over 60 years stimulated a number important works by economists, anthropologists, scientists historians. James Ferguson, anthropologist, recently attempted lengthy two part article this journal to survey literature on topic. present takes...
This technical procedure report introduces a newly developed method for removable partial denture (RPD) fabrication using computer-aided design and manufacturing (CAD/CAM) rapid prototyping (RP) technologies.Full-arch digital impressions of the partially edentulous jaw were made by an IOS or conventional method. The framework, artificial teeth, base designed commercially available CAD software. Each components including connectors, clasps, teeth bases fabricated separately CAM machine...
<p>Supplementary Figure 1: Strobe Flow Diagram.</p>
<p>Supplementary Figure 4: Flow cytometric analysis of T cell phenotypes in apheresis, infusion products and EGFRt + CAR cells at peak expansion.</p>
<div>AbstractPurpose:<p>The receptor tyrosine kinase–like orphan 1 (ROR1) is expressed in hematopoietic and epithelial cancers but has limited expression on normal adult tissues. This phase I study evaluated the safety of targeting ROR1 with autologous T lymphocytes engineered to express a chimeric antigen (CAR). Secondary objectives persistence, trafficking, antitumor activity CAR-T cells.</p>Patients Methods:<p>Twenty-one patients ROR1<sup>+</sup> tumors...
<p>Supplementary Figure 3: Lymphodepletion and CAR T cell expansion.</p>
<p>Supplementary Data 1: Study Protocol.</p>
<p>Supplementary Figure 2: Toxicity Assessment.</p>
Abstract Purpose: The receptor tyrosine kinase–like orphan 1 (ROR1) is expressed in hematopoietic and epithelial cancers but has limited expression on normal adult tissues. This phase I study evaluated the safety of targeting ROR1 with autologous T lymphocytes engineered to express a chimeric antigen (CAR). Secondary objectives persistence, trafficking, antitumor activity CAR-T cells. Patients Methods: Twenty-one patients ROR1+ tumors received cells at one four dose levels: 3.3 × 105, 106,...
Any consideration of the process decolonisation must be primarily concerned with question to whom power was transferred. Who inherited colonial state and how did they establish their claim? The basic thesis this article is that in order understand nature post-colonial Swaziland it necessary look back at least as far 1930s, trace roots Swazi ‘traditionalism’, ideology which triumphed over competing forms African nationalism during 1960s.
The optical, electrical and corrosion resistance properties of thin layers zirconium oxynitride are directly related to their structure chemical composition. In the present work a study composition film ZrOxNy from surface substrate-film interface is performed, its determined. coatings were deposited via RF magnetron sputtering, was analyzed by means X-ray photoelectron spectroscopy (XPS), microstructure characterized diffraction (XRD) patterns transmission electron microscopy (TEM),...
Abstract This contribution seeks to place the relationship between mining, housing and welfare in historical perspective two Southern African countries with long histories of mining activity that continue have large sectors, namely South Africa Zambia. Mining capitalists colonial, as well apartheid, governments tended resist urban permanence, but they were usually unable stop it. Economists social anthropologists, being less conscious than historians cyclical nature been prone discount...
The apparent camaraderie displayed by Presidents Jacob Zuma and Robert Mugabe, President Thabo Mbeki's 'tilt' towards Mugabe in electoral controversies Zimbabwe, have created the impression among many South Africa that African National Congress (ANC) Zimbabwe Union (ZANU) were allies struggle against apartheid. history of ANC/Zimbabwe People's (ZAPU) alliance has been neglected. This article focuses on almost unknown second phase 1978–80 its consequences. ZAPU, which lost for power 1980,...