A5030735621- Virus-based gene therapy research
- Pluripotent Stem Cells Research
- Nuclear Structure and Function
- Polyomavirus and related diseases
- RNA Interference and Gene Delivery
- Tissue Engineering and Regenerative Medicine
- 3D Printing in Biomedical Research
- Genomics and Chromatin Dynamics
- Animal Virus Infections Studies
- Viral Infectious Diseases and Gene Expression in Insects
- Cancer-related molecular mechanisms research
- CRISPR and Genetic Engineering
- Bone Tissue Engineering Materials
- Respiratory viral infections research
- RNA Research and Splicing
- Monoclonal and Polyclonal Antibodies Research
- Influenza Virus Research Studies
- Neuroscience and Neural Engineering
- Mesenchymal stem cell research
- Parvovirus B19 Infection Studies
Charles Sturt University
2014-2024
Wine Australia
2015
Human parvovirus B19 (B19V) is a major human pathogen causing variety of diseases, characterized by selective tropism to progenitor cells in bone marrow. In similar fashion all Parvoviridae members, the B19V ssDNA genome replicated within nucleus infected through process which involves both cellular and viral proteins. Among latter, crucial role played non-structural protein (NS)1, multifunctional involved replication transcription, as well modulation host gene expression function. Despite...
Abstract Influenza virus (IV) causes several outbreaks of the flu each year resulting in an economic burden to healthcare system billions dollars. Several influenza pandemics have occurred during last century and estimated caused 100 million deaths. There are four genera IV, A (IVA), B (IVB), C (IVC), D (IVD), with IVA being most virulent human population. Hemagglutinin (HA) is surface protein that allows attach host cell receptors enter cell. Here we characterised high-resolution structures...
Abstract Nucleocytoplasmic transport regulates the passage of proteins between nucleus and cytoplasm. In best characterized pathway, importin (IMP) α bridges cargoes bearing basic, classical nuclear localization signals (cNLSs) to IMPβ1, which mediates through pore complex. IMPα recognizes three types cNLSs via two binding sites: major site accommodates monopartite cNLSs, minor atypical while bipartite simultaneously interact with both sites. Despite growing knowledge regarding IMPα‐cNLS...
The ability to culture neurons from horses may allow further investigation into equine neurological disorders. In this study, we demonstrate the generation of induced neuronal cells adipose-derived stem (EADSCs) using a combination lentiviral vector expression transcription factors Brn2, Ascl1, Myt1l (BAM) and NeuroD1 defined chemical induction medium, with βIII-tubulin–positive displaying distinct morphology rounded compact cell bodies, extensive neurite outgrowth, branching processes....
SOX proteins are a family of transcription factors (TFs) that play critical functions in sex determination, neurogenesis, and chondrocyte differentiation, as well cardiac, vascular, lymphatic development. There 20 members humans, each sharing 79-residue L-shaped high mobility group (HMG)-box domain is responsible for DNA binding. SOX2 was recently shown to interact with long non-coding RNA large-intergenic regulate embryonic stem cell neuronal differentiation. The binding region reside...
Adeno-associated viruses (AAVs) are the most extensively researched viral vectors for gene therapy globally. The AAV protein 1 (VP1) N-terminus controls capsid's ability to translocate into cell nucleus; however, exact mechanism of this process is largely unknown. In study, we sought elucidate precise interactions between serotype 6 (AAV6), a promising vector immune disorders, and host transport receptors responsible nuclear localization. Focusing on positively charged basic areas within...
Abstract Nucleocytoplasmic transport is a fundamental eukaryotic process that regulates the passage of proteins between nucleus and cytoplasm, crucial for maintaining cellular homeostasis, gene expression, signal transduction. In best characterized pathway, importin (IMP) α bridges cargoes bearing basic, classical nuclear localization signals (cNLSs) to IMPβ1, which mediates through pore complex. IMPα recognizes three types cNLSs via two binding sites: major site accommodates monopartite...