Performing cardiac surgery under cardiopulmonary bypass (CPB) and circulatory arrest (CA) provokes the development of complications caused by tissue metabolism, microcirculatory disorders, endogenous nitric oxide (NO) deficiency. This study aimed to investigate potential mechanisms for systemic organoprotective effects exogenous NO during CPB CA based on assessment dynamic changes in glycocalyx degradation markers, deformation properties erythrocytes, metabolism experiment. A single-center...

Introduction. Chronic kidney disease (CKD) and arterial hypertension (AH), especially its resistant forms, are two closely related mutually aggravating diseases. The pathophysiology of CKD development in patients with AH is complex not limited to the negative impact hemodynamic, metabolic, neurohormonal proinflammatory factors. common pathophysiological mechanism both diseases visceral obesity, which has systemic local effects. However, aspects damage (RAH) require further study, their...

Enhancement of methods for protecting target organs during coronary artery bypass surgery determined the development a technology delivering nitric oxide (NO) to systemic blood flow using cardiopulmonary (CB) apparatus, which makes NO available all and tissues. The aim study was access effect perioperative conditioning on coefficients microviscosity polarity sheep etythrocyte membranes experimental surgical intervention CB. Material methods. Study carried out 20 weighing 30–34 kg. Two groups...

Chronic heart failure (CHF) is a clinical syndrome manifested by reduced pumping ability of the heart, increased pressure in chambers both physical activity and at rest.The symptoms this are dyspnea, undue fatigability, peripheral edema, which follow structural functional changes myocardium. [1]The growing incidence CHF, especially among elderly people, an urgent problem for medicine vast majority industrialized countries.For instance, Russian Federation, CHF diagnosed about 7%...

Background and Aims: Cardiopulmonary bypass (CPB) circulatory arrest (CA) can induce intestinal injury consequently lead to multiple organ dysfunction. Nitric oxide (NO) has protective effects, but its effect on the intestine not been studied. The study aimed investigate variables prove effects of exogenous nitric when modelling CPB CA in an experiment. Methods: was performed sheep ( n = 24). There were four groups: CPB, + NO, NO. Sheep NO groups received intraoperative inhalation at a dose...

Control of sympathetic hyperactivity is pivotal for treatment heart failure (HF) in patients with coronary artery disease (CAD). Our earlier studies demonstrated that the auricular pulsed electrical stimulation vagus nerve (VNS) beneficially affected condition CAD HF. The aim our study was to evaluate changes rate (HR) and levels heat shock proteins peripheral blood lymphocytes course VNS.The comprised 70 individuals aged 50-68 years chronic insufficiency, severe left ventricular...

Aim To study the functional condition of sympathoadrenal system as evaluated by beta-adrenoreactivity erythrocyte membranes (beta-ARM) during two years following renal denervation (RD) in patients with resistant arterial hypertension (RAH) and to determine relationship this index long-term antihypertensive cardioprotective effectivity invasive treatment. Material methods The included 48 (mean age, 57.2±8.7 years, 18 men) RAH on a stable therapy. Averaged daily systolic diastolic blood...

This pilot study was aimed to assess the percentage of patients admitted a Russian hospital and diagnosed with heart failure preserved ejection fraction (HFpEF) maintaining this diagnosis when evaluated against ESC 2016 2017 guidelines. In addition, we reviewed probability an HFpEF were assessed H2FPEF score. Forty-two (mean age 68 ±7,5) on their discharge record, between March 2018 May 2018, included. Twenty percent did not meet guideline criteria for due either absence symptoms and/or...

Heart rhythm disorders (HRDs) are one of the most complex and urgent problems in both adult pediatric cardiology. One important points research field arrhythmology is study mechanisms HRD formation. The that trigger arrhythmias children have their own peculiarity associated with age-related aspects formation cardiovascular system systems responsible for its regulation, primarily autonomic nervous (ANS). article presents current literature data on contribution ANS to information content...

Aim. To identify the associations between beta-adrenergic reactivity of erythrocytes and progression heart failure (HF) in patients after myocardial infarction (MI). Material methods. The study included 50 with HF history MI 6 months ago. determine level sympathoadrenal system activity, we analyzed by changing osmotic resistance use adrenoceptor blocking agent. Results. frequency index was 26% (n=13). All were divided into 2 groups depending on presence/absence postinfarction period. When...

INTRODUCTION: Ischemia-reperfusion injury during cardiopulmonary bypass (CPB) and circulatory arrest (CA) can lead to the damage of various body systems, including splanchnic. In turn, intestinal development multiple organ dysfunction. There is evidence protective properties nitric oxide (NO), but effects on intestine have not been studied. OBJECTIVE: To study effect exogenous degree tissue erythrocyte membranes when simulating in an experiment. MATERIALS AND METHODS: The was carried out...

To assess the association of CYP2C19 G681A, P2RY12 H1/H2, and ITGB3 T1565C polymorphisms with extent platelet aggregation in patients coronary heart disease (CHD) during antiplatelet therapy.166 male CHD, living Western Siberian Region, were examined. All underwent a test for induced by ADP (2.5 5.0 µm) epinephrine (0.2 µm). Genotyping was performed using an allele-specific polymerase chain reaction technique.The polymorphic variants genes ascertained to have no impact on receiving...

In patients with high risk of ventricular tachycardia (VT) the proven beneficial therapy is implantable cardioverter defibrillator (ICD). It has been shown that coronary artery disease (CAD) and VT development are accompanied by a persistent change sympathoadrenal system activity. This leads to decrease in total density erythrocyte membrane β-adrenergic receptors. The purpose this study was identify relationship membranes β-adrenoreactivity (EMA) CAD ICD.Sixty-three (male - 53, age 66.6 ±...

Background. According to the latest epidemiological data, heart failure (HF) is diagnosed in 10% of adult population over 70 years old. However, currently this diagnosis being increasingly made young and middleaged people. The pathogenesis HF may be based on a decrease respiration cardiomyocytes with age, which affects function energy-dependent processes cells. Aim. To study microviscosity their membranes rats aged 2 15 months failure. Materials methods. was carried out male Wistar rats....

Coupling of the functional stability rat myocardium and activity lipid peroxidation processes in combined development postinfarction remodeling diabetes mellitus has been studied. The was studied by means analysis inotropic reaction on extrasystolic stimulus, degree left ventricular hypertrophy, size scar zone. It shown that cardiac heart (PICR) with (DM) animal body weight decreased less than diabetic rats. Animals pathology had no hypertrophy. amplitude contractions rats PICR DM...

Aim. To define and develop a procedure that can select patients with resistant hypertension (RH) for renal sympathetic denervation (RSD) procedure, by being orienting to the specific initial values of β-adrenoreactivity (β-AR) systolic blood pressure (SBP). Subjects methods. The analysis included 23 RH receiving maximally tolerable doses 4 antihypertensive drugs. investigations involving BP control Russian spectrophotometric determining β-AR in terms change osmoresistance erythrocyte...

Introduction . Patients with resistant hypertension (RHTN) and type 2 diabetes mellitus (T2DM) are characterized by sympathetic hyperactivity. A promising method for the assessment is a measurement of erythrocyte membrane beta-adrenergic reactivity (β-ARM). However, little known about β-ARM in patients RHTN T2DM. Purpose To investigate properties erythrocytes T2DM relation to clinical, laboratory, instrumental data. Material Methods The cross-sectional study comprised 38 combined mean age...

To evaluate the efficacy of sotalol depending on magnitude changes in adrenal responsiveness and autonomic nervous system tone patients with paroxysmal atrial fibrillation (AF).Twenty-six AF presence coronary heart disease (CHD) hypertension were examined. Sinus rhythm variability sympathicotonic vagotonic disorders studied before during treatment. A commercial Beta-ARM-Agat kit was used to estimate erythrocyte membranes (β-APM), which can judge body's individual sensitivity...

Aim. To investigate time course of changes in the adrenoreactivity (AR) erythrocyte membranes (EM) after radiofrequency ablation synaptic nerves renal arteries (RA) patients with resistant hypertension (RH) and to assess whether this indicator can be used for early evaluation efficiency an invasive intervention into RA. Subjects methods. 24 RH, who received full-dose antihypertensive therapy at least three drugs, including a diuretic, were examined. Renal sympathetic denervation (RSD) was...