A5083799998- Microtubule and mitosis dynamics
- Animal Disease Management and Epidemiology
- Vector-Borne Animal Diseases
- Viral Infections and Immunology Research
- Plant Virus Research Studies
- Animal Virus Infections Studies
- Genomics and Chromatin Dynamics
- Cellular Mechanics and Interactions
- Chromosomal and Genetic Variations
- Nuclear Structure and Function
- Vector-borne infectious diseases
- T-cell and Retrovirus Studies
- Toxoplasma gondii Research Studies
- Bacteriophages and microbial interactions
- Ubiquitin and proteasome pathways
- Poxvirus research and outbreaks
- DNA Repair Mechanisms
- Viral Infections and Vectors
- Hippo pathway signaling and YAP/TAZ
Instituto Gulbenkian de Ciência
2020-2024
University of Lisbon
2014-2021
Centre for Research in Anthropology
2017
Two strains of African swine fever virus (ASFV), the high-virulence Lisboa60 (L60) and low-virulence NH/P68 (NHV), which have previously been used in effective immunization/protection studies, were sequenced. Both isolated Portugal during 11-year period after introduction ASFV to European Continent 1957. The predicted proteins coded by both compared, where differences found these also compared other known virulence. This highlighted several genes with significant alterations that may...
ABSTRACT African swine fever virus (ASFV) codes for a putative histone-like protein (pA104R) with extensive sequence homology to bacterial proteins that are implicated in genome replication and packaging. Functional characterization of purified recombinant pA104R revealed it binds single-stranded DNA (ssDNA) double-stranded (dsDNA) over wide range temperatures, pH values, salt concentrations an ATP-independent manner, estimated binding site size about 14 16 nucleotides. Using site-directed...
Abstract Nuclear positioning is an important aspect of cell and developmental biology. One example the apical nuclei in retinal other neuroepithelia. Here, nuclear migration crucial for correct tissue formation. Cytoskeletal mechanisms that drive to side have been explored. Yet, whether also properties influence remained comparatively less understood. Lamin A/C expression levels shown be directly related deformability. Further, it was many early development, including neuroepithelial nuclei,...
Abstract Mitotic chromatin is largely assumed incompatible with transcription due to changes in the machinery and chromosome architecture. However, mechanisms of mitotic transcriptional inactivation their interplay assembly remain unknown . By monitoring ongoing Drosophila early embryos, we reveal that eviction nascent mRNAs from occurs after substantial compaction not promoted by condensin I. Instead, show timely removal transcripts driven SNF2 helicase‐like protein Lodestar (Lds),...
Monopolar spindle One Binder1 (MOB1) proteins are conserved components of the tumor-suppressing Hippo pathway, regulating cellular processes such as cytokinesis. Apicomplexan parasites present a life cycle that relies on parasites' ability to differentiate between stages and regulate their proliferation; thus, signaling pathways could play an important role in regulation apicomplexan cycle. Here, we report identification one MOB1 protein Toxoplasma gondii. To characterize function MOB1,...
A bstract Mitotic chromatin is largely assumed incompatible with transcription due to changes in the machinery and chromosome architecture. However, mechanisms of mitotic transcriptional inactivation their interplay assembly remain unknown. By monitoring ongoing Drosophila early embryos, we reveal that eviction nascent mRNAs from occurs after substantial compaction not promoted by condensin I. Instead, show timely removal transcripts driven SNF2 helicase-like protein Lodestar (Lds),...