A5042932065- Adipose Tissue and Metabolism
- Cardiovascular and exercise physiology
- Nitric Oxide and Endothelin Effects
- Sirtuins and Resveratrol in Medicine
- Diet and metabolism studies
- Cardiovascular Disease and Adiposity
- Antioxidant Activity and Oxidative Stress
- Diet, Metabolism, and Disease
- Lipoproteins and Cardiovascular Health
- Heart Rate Variability and Autonomic Control
- Cardiovascular Function and Risk Factors
- Receptor Mechanisms and Signaling
- Traumatic Brain Injury and Neurovascular Disturbances
- Hormonal Regulation and Hypertension
- Renin-Angiotensin System Studies
- Physical Activity and Health
- Cardiac Ischemia and Reperfusion
- Traumatic Brain Injury Research
- Cardiovascular Effects of Exercise
- S100 Proteins and Annexins
- Exercise and Physiological Responses
- COVID-19 and Mental Health
- Metabolism and Genetic Disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease Diagnosis and Treatment
Central Queensland University
2015-2024
The University of Queensland
2001-2011
The novel coronavirus (COVID-19) has enforced dramatic changes to daily living including economic and health impacts. Evidence for the impact of these on our physical mental behaviors is limited. We examined associations between psychological distress in selected since onset COVID-19 Australia. An online survey was distributed April 2020 included measures depression, anxiety, stress, activity, sleep, alcohol intake cigarette smoking. completed by 1491 adults (mean age 50.5 ± 14.9 years, 67%...
The prevalence of metabolic syndrome including central obesity, insulin resistance, impaired glucose tolerance, hypertension, and dyslipidemia is increasing. Development adequate therapy for requires an animal model that mimics the human disease state. Therefore, we have characterized metabolic, cardiovascular, hepatic, renal, pancreatic changes in male Wistar rats (8-9 weeks old) fed on a high-carbohydrate, high-fat diet condensed milk (39.5%), beef tallow (20%), fructose (17.5%) together...
Background: Persistently poor glycemic control in adult type 1 diabetes patients is a common, complex, and serious problem initiating significant damage to the cardiovascular, renal, neural, visual systems. Currently, there plethora of low-cost free self-management smartphone applications available online stores. Objective: The aim this study was examine effectiveness freely application combined with text-message feedback from certified educator improve other diabetes-related outcomes...
Histone deacetylases (HDACs) silence genes by deacetylating lysine residues in histones and other proteins. HDAC inhibitors represent a new class of compounds with anti-inflammatory activity. This study investigated whether treatment broad spectrum inhibitor, suberoylanilide hydroxamic acid (SAHA), would prevent cardiac fibrosis, part the cardiovascular remodelling deoxycorticosterone acetate (DOCA)-salt rats.Control DOCA-salt rats were treated SAHA (25 mg x kg(-1) day(-1) s.c.) for 32 days....
Controversy around the safety and efficacy of COVID-19 vaccines may lead to low vaccination rates. Survey data were collected in April August 2020 from a total 2343 Australian adults. A quarter (n = 575, 24%) completed both surveys. generalized linear mixed model analysis was conducted determine whether willingness vaccinate changed repeated sample, multinominal logistic regression all participants associated with demographics, chronic disease, or media use. Willingness slightly decreased...
COVID-19 has resulted in substantial global upheaval. Resilience is important protecting wellbeing, however few studies have investigated changes resilience over time, and associations between with depression, anxiety, stress, physical activity during the pandemic.Online surveys were conducted to collect both longitudinal cross-sectional data at three time points 2020. Australian adults aged 18 years invited complete online surveys. Measures include six-item Brief Scale, 21-item Depression,...
This study has administered pirfenidone (5‐methyl‐1‐phenyl‐2‐[1H]‐pyridone) or amiloride to attenuate the remodelling and associated functional changes, especially an increased cardiac stiffness, in DOCA‐salt hypertensive rats. In control rats, elimination half‐life of following a single intravenous dose 200 mg kg −1 was 37 min while oral bioavailability at this 25.7%. Plasma concentrations rats averaged 1.9±0.1 μg ml over 24 h after 14 days' administration as 0.4% mixture food. Pirfenidone...
The phytoalexin resveratrol (3,4',5-trihydroxy-trans-stilbene) may attenuate cardiovascular disease in man. This study has determined whether treatment with (1 mg/kg/day orally) prevented cardiac fibrosis and the decreased function DOCA-salt hypertensive rat as a model of human hypertension. Uninephrectomised rats (UNX) administered DOCA (25mg every 4th day sc) 1% NaCl drinking water for 28 days developed vascular remodelling. In these rats, inflammatory cell infiltration, (left ventricular...
Intestinal microbiota modulates the development of clinical conditions, including metabolic syndrome and obesity. Many these conditions are influenced by nutritional exercise behaviours. This study aimed to investigate ability re-shape intestinal influence diet on process.A rat model was used examine responses four activity including: high-intensity interval training (HIIT), light-intensity (LIT), sedentary normal control, each containing two conditions: high-fat high-fructose (HF) standard...
Physical activity has the potential to reduce cardiometabolic risk factors but evaluation of different intensities physical and mechanisms behind their health effects still need be fully established. This study examined sedentary behaviour, light-intensity training, high-intensity interval training on biometric indices, glucose lipid metabolism, inflammatory oxidative stress markers, vascular cardiac function in adult rats. Rats (12 weeks old) were randomly assigned 1 4 groups: control (CTL;...
Nitric oxide (NO) is essential for normal function of the cardiovascular system. This study has determined whether chronic administration l-arginine, biological precursor NO, attenuates development structural and functional changes in hearts blood vessels deoxycorticosterone acetate (DOCA)-salt hypertensive rats. Uninephrectomized rats treated with DOCA (25 mg every 4th day sc) 1% NaCl drinking water 4 wk were l-arginine (5% food, 3.4 +/- 0.3 g x kg body wt(-1) day(-1)). Changes structure by...
Cardiovascular remodeling leading to heart failure is common in the elderly. Testing effective pharmacological treatment of human requires a suitable animal model that adequately mimics disease state.This study has characterized structural, functional, and electrical characteristics cardiovascular system throughout lifespan male female spontaneously hypertensive rats (SHRs), genetic chronic hypertension-induced remodeling, age- gender-matched normotensive controls, determine whether ageing...
The cardioprotective effects of resveratrol are well established in animal models metabolic disease but yet to be investigated a combined model hypertension and diabetes. This study the ability resveratrol's antioxidant anti-inflammatory prevent cardiovascular complications spontaneously hypertensive streptozotocin-induced diabetic rat. Diabetes was induced eight-week-old male rats via single intravenous injection streptozotocin. Following this, administered orally for an eight-week period...
Physical activity (PA) and diet are 2 lifestyle factors that affect cardiometabolic risk. However, data on how a high-fat high-carbohydrate (HFHC) influences the effect of different intensities PA health cardiovascular function in controlled setting yet to be fully established. This study investigated sedentary behavior, light-intensity training (LIT), high-intensity interval (HIIT) markers vascular cardiac HFHC-fed adult rats.Twelve-week-old Wistar rats were randomly allocated 4 groups (12...
Whole-body vibration exposure may translate into improved bone mass in young adult women. The primary focus of this study was to examine the effects graded whole-body or plus resistance training on mineral density (BMD), hematological measures for remodeling, and exercise metabolism women.There were 51 healthy active women [mean (SD) age, 21.02 (3.39) yr; height, 165.66 (6.73) cm; body 66.54 (13.39) kg] who participated intervention. Subjects randomly assigned (WBV), (WBV+RT), control (CONT)...