A5101397101- Luminescence and Fluorescent Materials
- Covalent Organic Framework Applications
- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Calcium signaling and nucleotide metabolism
- Advanced biosensing and bioanalysis techniques
- Metal-Organic Frameworks: Synthesis and Applications
- Lubricants and Their Additives
- Metal and Thin Film Mechanics
- Carbon and Quantum Dots Applications
- Mechanical Behavior of Composites
- Composite Structure Analysis and Optimization
- Structural Analysis of Composite Materials
- Tribology and Wear Analysis
East China Normal University
2021-2023
State Key Laboratory of Medicinal Chemical Biology
2016
Nankai University
2016
North Carolina State University
1991
Although organic semiconducting polymer nanoparticles (SPNs) have emerged as an important category of optical imaging agents, their application in molecular is still its infancy and faces many challenges. We herein report a straightforward one-pot synthetic approach to construct multilayered near-infrared (NIR) fluorescent SPNs with enhanced fluorescence optimized biodistribution for vivo imaging. In addition the SP core, middle silica protection layer outer poly(ethylene glycol) (PEG)...
Precise modulation of pH in living cells plays a vital role the study many diseases, such as cancer and rheumatoid arthritis. Here, series imine-linked covalent organic frameworks (COFs) were rationally designed developed for sensing tumor zebrafish. Four monomers chosen to synthesize COFs (COF1-COF4) with different pKa by simple orthogonal combination through condensation reaction. The as-obtained exhibited sensitive pH-dependent fluorescence response compared their building blocks. Among...
Synthesis of highly stable and emissive covalent organic frameworks (COFs) for biological applications is urgently needed. Herein, we developed a novel AIEgen-based sp2 carbon-conjugated COF (sp2c-COF) activatable imaging ferroptosis in target tumor cells. The sp2c-COFTFBE-PDAN was obtained by employing tetra-(4-aldehyde-(1,1-biphenyl)) ethylene (TFBE) as an AIEgen unit 1,4-phenylenediacetonitrile (PDAN) linker through the Knoevenagel reaction. as-obtained COFTFBE-PDAN exhibited high...
It is a great challenge to effectively treat triple-negative breast cancer (TNBC) due lack of therapeutic targets and drug resistance systemic chemotherapy. Rational design nanomedicine with good hemocompatibility urgently desirable for combination therapy TNBC. Herein, an erythrocyte membrane-camouflaged fluorescent covalent organic framework (COF) loaded NO donor (hydroxyurea, Hu), glucose oxidase (GOx) cytosine-phosphate-guanine oligonucleotides (CPG) (COF@HGC) was developed...
Calcium and chloride levels are closely related to lysosome dysfunction. However, the simultaneous measurement of calcium (Ca2+) (Cl-) in acidic subcellular organelles, which is conducive a deep understanding lysosome-related biological events, remains challenge. In this study, we developed pH-insensitive, ratiometric NIR nanoprobe for detection Ca2+ Cl- lysosomes determined roles two ions function. The upconversion with blue, green, red emissions was modified Ca2+-sensitive dye (Rhod-5N)...
As lubricating materials, the tribological performance of laminar transition metal dichalcogenides (TMDs), can be improved by compound oxide particles. In this study, MoSe2/MoOx heterogeneous nanostructures are easily obtained from a solvothermal reaction followed an annealed process in O2/N2 atmosphere. The composite, as lubricant additive, shows better than those pristine base oil, which includes friction coefficient and antiwear capability. enhanced attributed to lubrication layer...
A closed form solution is presented that predicts the response of filament wound composite shells subjected to internal pressure. The material shell assumed be general cylindrically anisotropic. Based on theory cylindrical anisotropic elasticity coupled differential equations are developed using Lekhnitskii's stress function approach. Two systems, graphite/epoxy and glass/epoxy, selected demonstrate influence degree anisotropy fiber orientations axial induced twisting deformation. Detailed...