A5024252659- Phytochemicals and Antioxidant Activities
- Enzyme function and inhibition
- Free Radicals and Antioxidants
- Synthesis and biological activity
- Phenothiazines and Benzothiazines Synthesis and Activities
- Pomegranate: compositions and health benefits
- Cholinesterase and Neurodegenerative Diseases
- Computational Drug Discovery Methods
- Berry genetics and cultivation research
- Antioxidant Activity and Oxidative Stress
- Food Quality and Safety Studies
- Plant Physiology and Cultivation Studies
- Bee Products Chemical Analysis
- Essential Oils and Antimicrobial Activity
- Synthesis and Characterization of Heterocyclic Compounds
Adıyaman University
2021-2024
Inonu University
2019-2022
Abstract Seven novel pyrazole derivatives ( 4a–g ) and four starting compounds incorporating substituted pyridine moieties were synthesized successfully. Cell viability assay for the tested was performed, inhibitory concentrationlogarithmic 50 (LogIC values of calculated after a 24‐h treatment. Four examined 3d , 3g 4f 4g showed comparable cytotoxic activity against CaCo‐2 compared to standard drug docetaxel at 0.1 1 μM concentrations. Although LogIC −0.678 cells 24 h, −0.794, −0.567,...
Six new monopeptides, seven dipeptides, and two deprotected monopeptide dihydroquinolinone conjugates were prepared by the benzothiazole-mediated method their structures confirmed nuclear magnetic resonance, mass, infrared spectroscopy, elemental analysis methods. The human carbonic anhydrase (hCA) I hCA II enzyme inhibition activities of compounds determined using stopped-flow instrument. synthesized peptide-dihydroquinolinone 2, 3, 6, 10, 13, 15 showed against in range 15.7-65.7 µM....
Punica granatum L. possesses significant nutritional and medicinal potential. Its pharmacological activities have been investigated, but no comparative evaluation has reported regarding the effect of different extraction solvents on phytochemical content antioxidant activity its leaf, bud, flower extracts. This research involved seven various solvents, namely methanol, ethanol, water, acidified hexane. A set experiments made it possible to define each these contents phenolics, flavonoids,...
Abstract In this study, 10 new indole‐dipeptide conjugates were synthesized, and their anticancer activity was determined against on A2780 (ovarian cancer cell line) MCF‐7 (breast cells. Among compounds, 5 showed better lines than the standard drug docatexel at 0.1 1 μM concentrations, while only compound docatexel, line concentrations. The antioxidant potencies of compounds low in both DPPH iron reducing power methods tested when compared to antioxidants used work.
Herein, a series of twelve bis-hydrazone substituted isovanilline derivatives 3(a-l), were freshly re-synthesized by the reaction bis-aldehydes with hydrazide since these compounds previously showed potent aldose reductase inhibition properties. The obtained tested for their potential antibacterial and antioxidant activities. In present study, four different bacterial strains used, including Gram-positive (Staphylococcus aureus ATCC 29213, Enterococcus faecalis 29212) Gram-negative...
Pomegranate is one of the most abundant fruit consumed in Turkey. This study aimed to determine content total phenolic, flavonoid and antioxidant activity Punica granatum L. flower different extracts. Antioxidant activities extracts were determined 2,2-diphenyl-1-picrylhydrazyl (DPPH•) radical scavenging, reducing power metal chelating methods. The result showed that, phenolic for was ranged from 14.82 90.86 mg gallic acid equivalents(GAE) / g extract. contents flavonoids found range 7.35...
In this study, total phenolics and flavonoid compounds of methanol extract concentrations three medicinal plant, Asteraceae (Compositae) L. genus that are grown in Turkey belong to the Achillea, were determined with goal measuring their antioxidant activities. Antioxidant capacity was measured by widely used iron reducing power, DPPH radical scavenging activity metal chelating capacity. The activities achillea extracts study compared standard antioxidants (BHA, BHT α-tocopherol), which...