A5028614626- GDF15 and Related Biomarkers
- Birth, Development, and Health
- Apelin-related biomedical research
- Free Radicals and Antioxidants
- Diverse Scientific Research Studies
- DNA and Nucleic Acid Chemistry
- Plant-Derived Bioactive Compounds
- Computational Drug Discovery Methods
- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
- Respiratory Support and Mechanisms
- Nitric Oxide and Endothelin Effects
- Thermal Regulation in Medicine
- Eicosanoids and Hypertension Pharmacology
- Flame retardant materials and properties
- Circadian rhythm and melatonin
- Phytochemistry Medicinal Plant Applications
- Plant tissue culture and regeneration
- Cancer, Hypoxia, and Metabolism
Turgut Özal University
2022-2025
Malatya Turgut Özal Üniversitesi
2023-2024
Inonu University
2023
Bartin University
2023
Abstract In this study, 10 new indole‐dipeptide conjugates were synthesized, and their anticancer activity was determined against on A2780 (ovarian cancer cell line) MCF‐7 (breast cells. Among compounds, 5 showed better lines than the standard drug docatexel at 0.1 1 μM concentrations, while only compound docatexel, line concentrations. The antioxidant potencies of compounds low in both DPPH iron reducing power methods tested when compared to antioxidants used work.
Amino acid conjugates are described by the reaction of amino acids with bioactive organic groups such as vitamins, hormones, flavonoids, steroids, and sugars. In this study, 12 new were synthesized cinnamic derivatives various acids. Cytotoxic studies against four different human cancer cells (MCF7, PC-3, Caco-2, A2780) carried out MTT assay method at five concentrations. The structure-activity relationships based on cell viability rates evaluated. To compare anticancer activities compounds...
ABSTRACT Acute kidney injury (AKI) is one of the leading causes chronic disease and accounts for 50%–75% mortality following renal pathologies or organ transplantation. Ischemia‒reperfusion (IRI) involves an interrupted blood supply to organs kidney; IRI exacerbates AKI development. Owing several pharmacological treatment methods, still has a poor prognosis, novel therapeutic options are needed. Agomelatine (AGM) melatonin receptor agonist (MT1 MT2) with increased bioavailability...
Abstract MOTS-c, a mitochondrial-derived peptide, acts as systemic hormone and MOTS-c level is inversely correlated with markers of obesity. Obesity risk factor for male reproductive physiology expressed an important cause infertility. In this study, we aimed to determine the effects which has been proven in hypothalamus testicles, on actors involved axis. 80 Wistar-Albino rats were divided into two main groups, obese non-obese (n = 40). Rats first group fed fatty diet feed obesity was...