A5045512430- Retinal Diseases and Treatments
- Ophthalmology and Visual Impairment Studies
- Retinal Imaging and Analysis
- Corneal surgery and disorders
- Retinal and Optic Conditions
- Long-Term Effects of COVID-19
- Heme Oxygenase-1 and Carbon Monoxide
- Protease and Inhibitor Mechanisms
- Vitamin D Research Studies
- Fatty Acid Research and Health
- Advanced Glycation End Products research
- Ocular Diseases and Behçet’s Syndrome
- Adenosine and Purinergic Signaling
- Eicosanoids and Hypertension Pharmacology
- Glaucoma and retinal disorders
- Ocular Surface and Contact Lens
- Retinal Development and Disorders
Universidad de Navarra
2022-2024
Bellvitge University Hospital
2022-2024
Clinica Universidad de Navarra
2020-2024
Navarre Institute of Health Research
2020
The purpose of this study was to evaluate the presence retinal and microvascular alterations in COVID-19 patients with bilateral pneumonia due SARS-COV-2 that required hospital admission compare a cohort age- sex-matched controls. underwent imaging 14 days after discharge structural optical coherence tomography (OCT) angiography (OCTA) measurements. Vessel density (VD) foveal avascular zone (FAZ) area were evaluated superficial, deep capillary plexus (SCP, DCP), choriocapillaris (CC). After...
Diabetic retinopathy is a vision-threatening microvascular complication of diabetes and one the leading causes blindness. Oxidative stress inflammation play major role in its pathogenesis, new therapies counteracting these contributors could be great interest. In current study, we investigated vitamin D against oxidative human retinal pigment epithelium (RPE) endothelial cell lines. We demonstrate that effectively counteracts induced by hydrogen peroxide (H2O2). addition, increased levels...
Retinal pigment epithelium (RPE) is a key regulator of retinal function and directly related to the transport, delivery, metabolism long-chain n-3 polyunsaturated fatty acids (n3-PUFA), in retina. Due their functions location, RPE cells are constantly exposed oxidative stress. Eicosapentaenoic acid (EPA) docosahexaenoic (DHA) have shown antioxidant effects by different mechanisms. For this reason, we designed an vitro study compare 10 formulations DHA EPA supplements from origins combined...
The purpose of this study was to evaluate the long-term evolution retinal changes in COVID-19 patients with bilateral pneumonia. A total 17 underwent imaging 6 months after hospital discharge structural optical coherence tomography (OCT) and angiography (OCTA). parafoveal nerve fiber layer (RNFL) ganglion cell (GCL) were significantly thinner at compared 0 (p = <0.001 both cases). In optic analysis, a RNFL observed 0.006) but persisted thickened, controls 0.02). vascular density (VD)...
Abstract Purpose To assess the effect of clinical factors on development and progression atrophy fibrosis in patients with neovascular age‐related macular degeneration (nAMD) receiving long‐term treatment real world. Methods An ambispective 36‐month multicentre study, involving 359 nAMD from 17 Spanish hospitals treated according to Vitreoretinal Society guidelines, was designed. The influence demographic factors, including presence location retinal fluid, best‐corrected visual acuity (BCVA)...
Age-related macular degeneration (AMD) is a multifactorial disease of the retina featured by dysfunction retinal pigmented epithelial (RPE) and loss photoreceptor cells under oxidative stress inflammatory conditions. Vitamin D antioxidants have beneficial effects against degenerative diseases, such as AMD. We investigated impact associating vitamin (ND) with nutritional antioxidant complex (Nutrof Total®; N) on inflammation-like induced conditions H2O2 LPS, respectively, in human (ARPE-19)...
Background: The objective of this study was to evaluate the association presence conjunctival ultraviolet autofluorescence (CUVAF) with level and progression myopia impact reduced sunlight exposure during COVID-19 pandemic confinement (PC). Methods: A retrospective observational carried out using three cohorts, children (9–17 years old), young adults (18–25 (>40 old) (≤0.75D) at least annual eye examinations (before after PC). All participants underwent an automatic refraction CUVAF area...
Myopia is the most common refractive error worldwide. This cannot be explained by genetic factors alone, therefore, environmental may play an important role. Hence, main objective of this study was to analyse whether outdoor exposure could exert a protective effect against development myopia in cohort young adults and investigate ultraviolet autofluorescence (CUVAF), as biomarker time spent outdoors. A cross-sectional observational carried out using two cohorts. total 208 participants were...
High myopia and the subsequent degenerative changes of retina, choroid, sclera, known as myopic maculopathy (MM), are a serious visual problem in many Asian countries, beginning to be so south Europe, especially Mediterranean. It is therefore necessary carry out genetic environmental studies determine possible causes this disease. This study aims verify if factors that have been most related populations also associated two Spanish cohorts. Eight SNPs from six genes (PAX6, SCO2, CCDC102B,...
The main aim of this study was to compare refraction measurements with and without cycloplegia from two refractors devices, (TRK-2P autorefractometer (TRK-2P) wavefront-based Visionix 130 (VX130)) in children adolescents. This descriptive observational included 20 myopic eyes 40 hyperopic measured different Spanish hospitals. Cycloplegia carried out by three drops cyclopentolate hydrochloride 1% (Colircusí cycloplegic, Alcon Healthcare S.A., Barcelona). mean age the myopia group 12.40 ± 3.48...
The purpose of this study was to assess vascular and histological alterations in two COVID-19 three control post-mortem retinas. macular areas flat-mounted samples were processed for immunofluorescence. Lectin collagen IV positive vessels captured under confocal microscopy, endothelium loss tortuosity analyzed. Expression ACE2 (angiotensin-converting enzyme 2) (the receptor SARS-CoV-2), Iba1 (ionized calcium-binding adaptor molecule 1) GFAP (glial fibrillary acidic protein) quantified...
Aims/Purpose: The purpose of this study was to analyse whether the changes in habits during pandemic confinement have resulted a significantly greater increase dioptres (D) children and young people compared those another year prior Confinement (PC). Moreover, CUVAF, as an objective measure time spent outdoors, also investigated cohort. Methods: A retrospective observational carried out using three different cohorts participants, one (9–17 years old), second (18–25 old) finally, adults...
The prevalence of myopia has increased significantly in recent years including an earlier onset development on the pediatric population. main objective study is to compare CUVAF (Conjunctival Ultraviolet Autofluorescence) children with and without validate its usefulness as outdoor protective biomarker.
Age-related macular degeneration (AMD) is a leading cause of severe vision loss in older individuals developed countries. Despite advances our understanding AMD, its pathophysiology remains poorly understood. Matrix metalloproteinases (MMPs) have been proposed to play role AMD development. In this study, we aimed characterize MMP-13 AMD. We used retinal pigment epithelial cells, murine model laser-induced choroidal neovascularization, and plasma samples from patients with neovascular conduct...
Age-related macular degeneration (AMD) is currently the main cause of severe visual loss among older adults in developed countries. The pathophysiology has not been clarified, but oxidative stress believed to play a major role. Matrix metalloproteinases (MMP) may prominent role several steps AMD, especially its neovascular form; therefore, there great interest understanding their choroidal neovascularisation. This study aimed elucidate MMP10 development neovascularisation (CNV). We have...