A5036051094- Retinal Diseases and Treatments
- Retinal Development and Disorders
- Ovarian cancer diagnosis and treatment
- CRISPR and Genetic Engineering
- Retinal Imaging and Analysis
- Reproductive tract infections research
- Cancer Genomics and Diagnostics
- PARP inhibition in cancer therapy
- Syphilis Diagnosis and Treatment
- Retinal and Optic Conditions
- Cancer Immunotherapy and Biomarkers
- Hepatitis Viruses Studies and Epidemiology
- Glaucoma and retinal disorders
- Eicosanoids and Hypertension Pharmacology
- Neuroendocrine Tumor Research Advances
- Immune Cell Function and Interaction
- RNA Interference and Gene Delivery
- Cancer Research and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Sarcoma Diagnosis and Treatment
- Fibroblast Growth Factor Research
- Cancer Cells and Metastasis
- Pancreatic and Hepatic Oncology Research
- RNA regulation and disease
- Connexins and lens biology
Hospital Clínic de Barcelona
2014-2024
Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas
2022-2024
Centre for Biomedical Network Research on Rare Diseases
2022-2024
Universidad Autónoma de Madrid
2018-2024
Hospital Universitario Fundación Jiménez Díaz
2018-2024
Hospital Universitario de Gran Canaria Doctor Negrín
2024
University of California, San Diego
2023
Universidad Rey Juan Carlos
2010-2023
Instituto de Salud Carlos III
2013-2023
Instituto de Investigación de Enfermedades Raras
2013-2023
Human adipose–derived mesenchymal stem cells (hASCs) are (MSCs) with reduced immunogenicity and capability to modulate immune responses. Whereas the immunosuppressive activity of bone marrow–MSCs has received considerable attention during last few years, specific mechanisms underlying hASC-mediated immunosuppression have been poorly studied. Recent studies comparing both cell types reported differences at transcriptional proteomic levels, suggesting that hASCs marrow–MSCs, while having...
Abstract Background Primary resistance to anti-EGFR therapies affects 40% of metastatic colorectal cancer patients harbouring wild-type RAS/RAF . YAP1 activation is associated with this resistance, prompting an investigation into AURKA’s role in mediating phosphorylation at Ser397, as observed breast cancer. Methods We used transcriptomic analysis along vitro and vivo models CRC study Ser397 a potential biomarker for cetuximab resistance. assessed efficacy using CCK8 proliferation assays...
Abstract Fanconi Anemia (FA) is a debilitating genetic disorder with wide range of severe symptoms including bone marrow failure and predisposition to cancer. CRISPR-Cas genome editing manipulates genotypes by harnessing DNA repair has been proposed as potential cure for FA. But FA caused deficiencies in itself, preventing the use strategies such homology directed repair. Recently developed base (BE) systems do not rely on double stranded breaks might be used target mutations genes, but this...
In the field of data security intrusion detection, challenge lies in effectively identifying and categorizing activities amidst influx data. Current research predominantly focuses on traditional methods that may overlook subtle yet significant patterns, thereby hindering accurate detection. This paper addresses this gap by proposing a novel approach - A Density-Based Spatial Clustering Applications with Noise (DBSCAN) for Data Security Intrusion Detection. By harnessing power density-based...
Retinal pigment epithelium (RPE) is a key regulator of retinal function and directly related to the transport, delivery, metabolism long-chain n-3 polyunsaturated fatty acids (n3-PUFA), in retina. Due their functions location, RPE cells are constantly exposed oxidative stress. Eicosapentaenoic acid (EPA) docosahexaenoic (DHA) have shown antioxidant effects by different mechanisms. For this reason, we designed an vitro study compare 10 formulations DHA EPA supplements from origins combined...
Identification of the genetic risk factors that contribute to geographic atrophy (GA) could lead advancements in interventional trials and/or therapeutic approaches for combating vision loss.To investigate whether single-nucleotide polymorphisms (SNPs) are associated with presence and progression established GA age-related macular degeneration (AMD).Prospective, controlled, multicenter study 154 patients GA/AMD 141 age-matched control participants at 8 Spanish hospitals.Samples DNA were...
Ewing sarcoma is the second most common bone malignancy in children and young adults. It driven by oncogenic fusion proteins (i.e. EWS/FLI1) acting as aberrant transcription factors that upregulate downregulate target genes, leading to cellular transformation. Thus, identificating these genes understanding their contribution tumorigenesis are key for development of new therapeutic strategies. In this study we show lysyl oxidase (LOX), an enzyme involved maintaining structural integrity...
Abstract The molecular recognition of several glycopeptides bearing Tn antigen (α‐ O ‐GalNAc‐Ser or α‐ ‐GalNAc‐Thr) in their structure by three lectins with affinity for this determinant has been analysed. work yields remarkable results terms epitope recognition, showing that the underlying amino acid (serine threonine) plays a key role recognition. In fact, while Soybean agglutinin and Vicia villosa prefer Tn‐threonine, Helix pomatia shows higher carrying Tn‐serine. different conformational...
The chimeric EWSR1::FLI1 transcription factor is the main oncogenic event in Ewing sarcoma. Recently, it has been proposed that levels can fluctuate sarcoma cells, giving rise to two cell populations. EWSR1::FLI1low cells present a migratory and invasive phenotype, while EWSR1::FLI1high are more proliferative. In this work, we described how CD44 standard isoform (CD44s), transmembrane protein involved adhesion migration, overexpressed phenotype. functional characterization of CD44s...
In recent years, there has been an increase in the number of cases certain immunopreventable diseases our country. A high proportion these have recorded among young adult population. The aim this study was to determine seroprevalence antibodies against with greatest health impacts on population (19-39 y age) Madrid. We collected a total 1,153 serum samples from healthy volunteers undergoing routine medical visits and used ELISA presence IgG measles, rubella, mumps, varicella zoster, as well...
Ewing sarcoma is an aggressive bone cancer affecting children and young adults. The main molecular hallmark of are chromosomal translocations that produce chimeric oncogenic transcription factors, the most frequent which aberrant factor EWSR1–FLI1. Because this principal driver sarcoma, its inactivation should be best therapeutic strategy to block tumor growth. In study, we genetically inactivated EWSR1–FLI1 using CRISPR-Cas9 technology in order cause permanent gene inactivation. We found...
New therapeutic targets are revolutionizing colorectal cancer clinical management, opening new horizons in metastatic patients' outcome. Polo Like Kinase1 (PLK1) inhibitors have high potential as antitumoral agents, however, the emergence of drug resistance is a major challenge for their use practice. Overcoming this represents hot topic current discovery research. BI2536-resistant cell lines HT29R, RKOR, SW837R and HCT116R, were generated vitro validated by IG50 assays xenografts models T/C...
We examined the effect of nutritional supplements (modified Age Related Eye Disease Study (AREDS)-II formulation containing vitamins, minerals, lutein, resveratrol, and omega-3 fatty acids) on choroidal neovascularization (CNV). Supplements were administered alone combined with intravitreal anti-VEGF in an early-CNV (diode laser-induced) murine model. Sixty mice evenly divided into group V (oral vehicle, saline), S supplement, + aVEGF anti-VEGF), anti-VEGF). Vehicle daily for 38 days...