A5002910206- Virus-based gene therapy research
- Systemic Lupus Erythematosus Research
- CRISPR and Genetic Engineering
- Hematopoietic Stem Cell Transplantation
- Viral Infectious Diseases and Gene Expression in Insects
- Mitochondrial Function and Pathology
- Immunotherapy and Immune Responses
- Neurogenetic and Muscular Disorders Research
- Mesenchymal stem cell research
- RNA Interference and Gene Delivery
- Metabolism and Genetic Disorders
- Immune cells in cancer
- Pancreatic function and diabetes
- Platelet Disorders and Treatments
- Immune Response and Inflammation
- Renal Diseases and Glomerulopathies
- Immune Cell Function and Interaction
- Pluripotent Stem Cells Research
- CAR-T cell therapy research
- Cancer-related gene regulation
- DNA Repair Mechanisms
- Blood disorders and treatments
- T-cell and B-cell Immunology
- Immunodeficiency and Autoimmune Disorders
- Chronic Lymphocytic Leukemia Research
Vall d'Hebron Institut de Recerca
2013-2024
Universitat Autònoma de Barcelona
2009-2024
Vall d'Hebron Hospital Universitari
1989-2022
Erasmus University Rotterdam
1998-2015
Erasmus MC
2015
Banc de Sang i Teixits
2001-2011
Universitat de Barcelona
2009
Institut Català d'Oncologia
1997-2005
Institute for Transfusion Medicine
2005
Ajuntament de L’Hospitalet
1997
▪ Objective: To determine the prevalence of cardiac valvular involvement in patients with primary antiphospholipid syndrome. Design: Cross-sectional study evaluation case and control by Doppler echocardiography. The mean follow-up for was 21 months. Setting: University-based tertiary medical center. Patients: Twenty-eight consecutive who were diagnosed syndrome during a 10-year period; 28 age- sex-matched healthy controls. Measurements Main Results: Ten (36%; 95% Cl, 19% to 56%) had...
Summary High levels of IgG antiphospholipid antibodies (aPL) have been associated with clinical thrombosis. It is uncertain however whether these play a direct role in thrombosis or are merely epiphenomena. To investigate might thrombosis, we utilized novel mouse model which the dynamics vivo can be studied. CD1 mice (26-30 g) were passively immunized 25 mg human from patient Antiphospholipid Syndrome (IgG-APS) (n = 17), normal pooled sera (TgG-NHS) 9). saline solution followed by 40 same...
MicroRNA 155 (miR-155) is involved in immune and inflammatory diseases associated with liver fibrosis steatohepatitis. However, the mechanisms miR-155 regulation of injury are largely unknown. The role acute was assessed wild-type (WT), miR-155-/- , mice transplanted WT bone marrow. Additionally, expression evaluated tissue peripheral blood mononuclear cells patients autoimmune hepatitis. Concanavalin A, but not acetaminophen, treatment increased mice. A induced increases cell death,...
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an autosomal recessive disorder caused by mutations in TYMP, enconding thymidine phosphorylase (TP). TP deficiency results systemic accumulation of and deoxyuridine, which interferes with mitochondrial DNA (mtDNA) replication leads to dysfunction. To date, the only treatment available for MNGIE patients allogeneic hematopoietic stem cell transplantation, associated high morbidity mortality. Here, we report that AAV2/8-mediated...
Myeloid‐derived suppressor cells (MDSCs) have an important role in controlling inflammation. As such, they are both a therapeutic target and, based on the administration of ex vivo ‐generated MDSCs, tool. However, there relatively few reports describing methods to generate human and most them rely obtained from peripheral blood monocytes. We investigated alternative approaches generation MDSCs hematopoietic progenitors Purified CD34 + apheresis products CD14 isolated buffy coats were...
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a metabolic disorder caused by mutations in TYMP, encoding thymidine phosphorylase (TP). In MNGIE patients, TP dysfunction produces systemic and deoxyuridine accumulation, which ultimately impairs mitochondrial DNA replication results dysfunction. To date, only allogeneic hematopoietic stem cell transplantation has demonstrated long-term clinical efficacy, but high morbidity mortality associated with this procedure necessitate...
A group of seven young women with antiphospholipid antibodies, histories recurrent fetal loss, and no live births is reported. Two patients had systemic lupus erythematosus, the other five fulfilled criteria for primary syndrome. false Venereal Disease Research Laboratory (VDRL) test was present in four patients, three a previous episode arterial or venous thrombosis, both, two thrombocytopenia. Prednisone acetylsalicylic acid were given, monthly controls anticoagulant activity carried out....
The use of multipotent mesenchymal stromal cells (MSCs) as candidate medicines for treating a variety pathologies is based on their qualities either progenitors the regeneration damaged tissue or producers number molecules with pharmacological properties. Preclinical product development programmes include well characterized cell populations proof efficacy and safety studies before testing in humans. In field orthopaedics, an increasing translational sheep vivo test system because...
Experimental autoimmune encephalomyelitis (EAE) constitutes a paradigm of antigen (Ag)-specific T cell driven diseases. In this study, we transferred bone marrow cells (BMCs) expressing an autoantigen (autoAg), the peptide 40-55 myelin oligodendrocytic glycoprotein (MOG(40-55)), to induce preventive and therapeutic immune tolerance in murine EAE model. Transfer BMC MOG(40-55) (IiMOG-BMC) into partially myeloablated mice resulted molecular chimerism robust protection from experimental...