A5003298076- Malaria Research and Control
- Mosquito-borne diseases and control
- Adenosine and Purinergic Signaling
- Neuroscience of respiration and sleep
- Neuroscience and Neuropharmacology Research
- Complement system in diseases
- vaccines and immunoinformatics approaches
- Mass Spectrometry Techniques and Applications
- Respiratory viral infections research
- RNA and protein synthesis mechanisms
- Sleep and Wakefulness Research
- Pneumonia and Respiratory Infections
- Neuroinflammation and Neurodegeneration Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Parasites and Host Interactions
- Aquaculture disease management and microbiota
- Antimicrobial Peptides and Activities
- Hepatitis Viruses Studies and Epidemiology
- Vector-borne infectious diseases
- Molecular Sensors and Ion Detection
- Virology and Viral Diseases
- Redox biology and oxidative stress
- Toxoplasma gondii Research Studies
- Vagus Nerve Stimulation Research
- Autoimmune Neurological Disorders and Treatments
Universidad Rey Juan Carlos
2013-2025
Universidad Complutense de Madrid
2006-2024
General Department of Preventive Medicine
2015
Creative Commons
2015
Hospital Universitario Fundación Jiménez Díaz
2015
Research Institute Hospital 12 de Octubre
2012-2014
Universidad Europea
2011-2012
Universidad Europea
2011
Significance Malaria remains one of the main health threats in developing world, with staggering social and economic costs. Resistance to artemisins, pharmacological tool currently available against malaria, has been widely reported. Borrelidin, a natural compound that inhibits threonyl-tRNA synthetase, long studied for its antibacterial antiparasitic properties, but undesirable toxic effects prevented further clinical development. Here we present group borrelidin derivatives retain their...
This epidemiological survey in Spain estimates the burden of respiratory syncytial virus (RSV) infection children up to 5 year age during a 15-year period (1997–2011). Observational retrospective was conducted by reviewing data National Surveillance System for Hospital Data, including >98% Spanish hospitals. All hospitalizations related RSV years, reported 1997–2011 period, were analyzed. Codes selected using International Classification Diseases 9th Clinical Modification 466.0–466.19,...
Pneumococcal disease is a leading cause of morbidity and mortality worldwide. From 2016 to 2022, 358,603 hospitalized patients were identified as having pneumococcal disease. The overall annual hospitalization rate was 108.9 hospitalizations per 100,000 people, which significantly increased with age, reaching 748.0 among those aged ≥90 years. rates for pneumonia, meningitis, sepsis 25.4, 0.7, 3.5 respectively, the highest in years age pneumonia sepsis, 241.6 22.0 <1 year 3.4 people. total...
The presence of ionotropic P2X 7 receptor has been studied in mice brain from wild type and knockout animals. Western blot immunocytochemical assays show the a protein containing immunogenic epitopes model. Reverse transcriptase polymerase chain reaction experiments demonstrate absence disrupted sequence, but other sequences specific mRNA expression have detected. Functional calcium imaging cultured granule neurons cerebella existence functional ‐like that keeps some properties genuine receptor.
Abstract Background Natural products have played an important role as leads for the development of new drugs against malaria. Recent studies shown that maslinic acid (MA), a natural triterpene obtained from olive pomace, which displays multiple biological and antimicrobial activities, also exerts inhibitory effects on some Apicomplexan, including Eimeria, Toxoplasma Neospora . To ascertain if MA anti-malarial activity, main objective this study was to asses effect Plasmodium falciparum...
Blood-stage Plasmodium parasites cause morbidity and mortality from malaria. Parasite resistance to drugs makes development of new chemotherapies an urgency. Aminoacyl-tRNA synthetases have been validated as antimalarial drug targets. We explored long-term effects borrelidin mupirocin in lethal P. yoelii murine
In recent years, there has been an increase in the number of cases certain immunopreventable diseases our country. A high proportion these have recorded among young adult population. The aim this study was to determine seroprevalence antibodies against with greatest health impacts on population (19-39 y age) Madrid. We collected a total 1,153 serum samples from healthy volunteers undergoing routine medical visits and used ELISA presence IgG measles, rubella, mumps, varicella zoster, as well...
Abstract The resistance of malaria parasites to available drugs continues grow, and this makes the need for new antimalarial therapies pressing. Aminoacyl‐tRNA synthetases (ARSs) are essential enzymes well‐established antibacterial targets so constitute a promising set development antimalarials. Despite their potential as drug targets, apicoplastic ARSs remain unexplored. We have characterized lysylation system Plasmodium falciparum , designed, synthesized, tested inhibitors based on...
Improvements on malarial diagnostic methods are currently needed for the correct detection in low-density Plasmodium falciparum infections. Microfluorimetric DNA-based assays have been previously used evaluation of anti-malarial drug efficacy infected erythrocytes. Several factors affecting sensitivity these evaluated, and tested quantification parasite low parasitaemia conditions.Parasitaemia was assessed by measuring SYBRGreen I (SGI) PicoGreen (PG) fluorescence P. Dd2 cultures human red...
Oxidative stress plays a critical role in the pathogenesis of number diseases. The carbonyl end products protein oxidation are among most commonly measured markers biological samples. Protein functional groups may be derivatized with 2,4-dinitrophenylhydrazine (DNPH) to render stable 2,4-dinitrophenylhydrazone-protein (DNP-protein) and contents individual proteins then determined by two-dimensional electrophoresis followed immunoblotting using specific anti-DNP antibodies. Unfortunately,...
Abstract Background The anti-malarial activity of maslinic acid (MA), a natural triterpene which has been previously shown to exert parasitostatic action on Plasmodium falciparum cultures, was analysed in vivo by using the yoelii 17XL murine model. Methods ICR mice were infected with P. and treated single dose MA intraperitoneal injection (40 mg kg -1 day ) followed identical administration for following three days. Parasitaemia accumulation intraerythrocytic stages monitored...
In cerebral malaria, the most severe complication of both neurotransmission mechanisms and energy metabolism are affected. To understand how metabolic changes modify neurotransmission, we examined P2 receptor expression in a murine model malaria. Quantitative polymerase chain reaction experiments revealed that parasite deposition was greatest cerebellum, compared with other areas brain, suggesting correlation between brain parasitemia loss control movement. Infected mice showed modified...
This epidemiological survey estimates the burden of whooping cough in infants up to 12 months old Spain during a twenty-one-year period (1997-2017). The was conducted by reviewing data from Spanish Surveillance System for Hospital Data. All hospitalizations due infants, reported 1997-2017 period, were analysed. Codes selected International Classification Diseases, 9th Revision, Clinical Modification diagnosis codes 033.0-033.9. To explore latest national outbreak and implementation...
Malaria infection in humans elicits a wide range of immune responses that can be detected peripheral blood, but we lack detailed long-term follow-up data on the primary and subsequent infections lead to naturally acquired immunity. Studies antimalarial mice have been based models yielding homogenous profiles. Here, present mouse model which heterogeneous course Plasmodium yoelii lethal malaria is produced non-congenic ICR strain allow comparison among different immunological clinical...