A5020006084- Cannabis and Cannabinoid Research
- Neurotransmitter Receptor Influence on Behavior
- Alcohol Consumption and Health Effects
- Diet, Metabolism, and Disease
- Diet and metabolism studies
- Forensic Toxicology and Drug Analysis
- Sleep and Wakefulness Research
- Neuroscience of respiration and sleep
- Neuroscience and Neuropharmacology Research
- Nutritional Studies and Diet
- Adipose Tissue and Metabolism
- Olfactory and Sensory Function Studies
- Eating Disorders and Behaviors
- Dietary Effects on Health
- Pancreatic function and diabetes
- Peroxisome Proliferator-Activated Receptors
- Edible Oils Quality and Analysis
- Williams Syndrome Research
- Spectroscopy and Chemometric Analyses
- Drug-Induced Hepatotoxicity and Protection
- Nuclear Receptors and Signaling
- Antioxidant Activity and Oxidative Stress
- Prenatal Substance Exposure Effects
- Natural product bioactivities and synthesis
- Cholesterol and Lipid Metabolism
Instituto de Salud Carlos III
2014-2025
Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
2015-2025
Hospital Del Mar
2015-2024
Hospital del Mar Research Institute
2014-2023
Municipal Institute for Medical Research
2013-2023
Weatherford College
2023
The University of Melbourne
2023
Universitat de Barcelona
2023
Bellvitge University Hospital
2023
Institut d'Investigació Biomédica de Bellvitge
2023
Activation of cannabinoid CB1 receptors (CB1R) by delta9-tetrahydrocannabinol (THC) produces a variety negative effects with major consequences in cannabis users that constitute important drawbacks for the use cannabinoids as therapeutic agents. For this reason, there is tremendous medical interest harnessing beneficial THC. Behavioral studies carried out mice lacking 5-HT2A (5-HT2AR) revealed remarkable 5-HT2AR-dependent dissociation antinociceptive THC and its detrimental amnesic...
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Orally administered synthetic cannabinoids (nabilone and dronabinol) have been shown to be superior dopamine receptor antagonists in preventing chemotherapy‐induced nausea vomiting (CINV). There is no information on the tolerability of an acute dose titration a whole‐plant cannabis‐based medicine (CBM). The efficacy cannibidiol with tetrahydrocannabinol added current standard therapy control CINV after moderately emetic cancer chemotherapy (MEC)...
Hydroxytyrosol and tyrosol are dietary phenolic compounds present in virgin olive oil wine. Both also endogenously synthesized our body as byproducts of dopamine tyramine metabolisms, respectively. Over the last decades, research into hydroxytyrosol has experienced an increasing interest due to role that these may play prevention certain pathologies (e.g. cardiovascular, metabolic, neurodegenerative diseases cancer). The translation promising vitro vivo biological effects from preclinical...
Although the efficacy of methadone maintenance treatment (MMT) in opioid dependence disorder has been well established, influence pharmacokinetics dose requirement and clinical outcome remains controversial. The aim this study is to analyze dosage responder nonresponder patients considering pharmacogenetic pharmacokinetic factors that may contribute adequacy. Opioid (meeting Diagnostic Statistical Manual Mental Disorders, [4th Edition] criteria) from a MMT community program were recruited....
In Brief this study, we investigated the role of endocannabinoid system (ECS) in emotional and cognitive alterations associated with osteoarthritis pain. The monosodium iodoacetate model was used to evaluate affective manifestations pain type 1 (CB1R) 2 (CB2R) cannabinoid receptor knockout wild-type mice ability CB1R (ACEA) CB2R (JWH133) selective agonists improve these during a 3-week time period. levels endocannabinoids anandamide (AEA) 2-arachidonoylglycerol (2-AG) were measured plasma...
The endocannabinoid (eCB) system can promote food intake by increasing odor detection in mice. eCB is over-active human obesity. Our aim to measure circulating concentrations and olfactory capacity a sample that includes people with obesity explore the possible interaction between olfaction, system. study was made up of 161 females five groups body mass index sub-categories ranging from under-weight morbidly obese. We assessed "Sniffin´Sticks" test, which measures...
The analysis of peripheral endocannabinoids (ECs) is a good biomarker the EC system. Their concentrations, from clinical studies, strongly depend on sample collection and time processing conditions taking place in laboratory settings. 2-monoacylglycerols (MGs) (i.e., 2-arachidonoylglycerol or 2-oleoylglycerol) particularly challenging issue because their ex vivo formation chemical isomerization that occur after blood collection. We provide evidence can be minimized by adding Orlistat, an...
Despite the increasing concern about gamma-hydroxybutyric acid (GHB) toxicity, there are few studies examining clinical pharmacology of GHB and its abuse potential. To evaluate GHB-induced subjective physiological effects, relative liability impact on psychomotor performance in club drug users. Twelve healthy male recreational users participated 5 experimental sessions framework a trial. The study was randomized, double-blind, double-dummy, crossover. Drug conditions were single oral dose...
Cocaine is associated with serious health problems including psychiatric co-morbidity. There a need for the identification of biomarkers stratification cocaine-addicted subjects. Several studies have evaluated circulating endocannabinoid-related lipids as inflammatory, metabolic and mental disorders. However, little known in substance use This study characterizes both free N-acyl-ethanolamines (NAEs) 2-acyl-glycerols abstinent cocaine addicts from outpatient treatment programs who were...
Endocannabinoids participate in the control of neurogenesis, neural cell death and gliosis. The pharmacological effect fatty acid amide hydrolase (FAAH) inhibitor URB597, which limits endocannabinoid degradation, was investigated present study. Cell proliferation (phospho-H3+ or BrdU+ cells) main adult neurogenic zones as well apoptosis (cleaved caspase-3+), astroglia (GFAP+), microglia (Iba1+ were analyzed hippocampus, hypothalamus striatum rats intraperitoneally treated with URB597 (0.3...
Endocannabinoids and temperament traits have been linked to both physical activity body mass index (BMI) however no study has explored how these factors interact in females. The aims of this cross-sectional were 1) examine differences among distinct BMI groups on daytime time spent moderate-vigorous (MVPA), plasma endocannabinoid concentrations; 2) explore the association interaction between MVPA, temperament, endocannabinoids BMI.Physical was measured with wrist-worn accelerometer Actiwatch...
There are sex differences in the progression of drug addiction, relapse and response to therapies. Because biological factors participate these differences, they should be considered when using biomarkers for addiction. In current study, we evaluated psychiatric comorbidity concentrations plasma mediators that have been reported affected by cocaine. Fifty-five abstinent cocaine-addicted subjects diagnosed with lifetime cocaine use disorders (40 men 15 women) 73 healthy controls (48 25 were...
Substance use disorder (SUD) is a major global public health challenge, frequently co-occurring with psychiatric conditions such as attention-deficit/hyperactivity (ADHD). Endocannabinoid system (ECS) dysregulation has been implicated in both SUD and ADHD, but the interplay between these remains poorly understood. This study investigates plasma concentrations of endocannabinoid-congeners individuals SUD, without comorbid to identify potential biomarkers. exploratory included 469 participants...
Little controlled drug administration data are available to aid in the interpretation of gamma-hydroxybutyric acid (GHB) distribution conventional and nonconventional fluids potential correlation between pharmacokinetics GHB effects. Single oral sodium doses 50 mg/kg were administered five volunteers. Plasma, fluid, urine, sweat analyzed for by gas chromatography-mass spectrometry. stability plasma was studied at different storage temperatures. Subjective effects measured using a set 13...
The prefrontal (PFC) and orbitofrontal cortex (OFC) appear to be associated with both executive functions olfaction. However, there is little data relating olfactory processing in humans. present study aimed at exploring the role of olfaction on functioning, making a distinction between primary more cognitive aspects Three tasks similar difficulty were used. One was used assess hot (Iowa Gambling Task-IGT), two as measure cold functioning (Stroop Colour Word Test-SCWT Wisconsin Card Sorting...
Abstract Background The Mediterranean diet (MedDiet) has demonstrated efficacy in preventing age-related cognitive decline and modulating plasma concentrations of endocannabinoids (eCBs) N- acylethanolamines (NAEs, or eCB-like compounds), which are lipid mediators involved multiple neurological disorders metabolic processes. Hypothesizing that eCBs NAEs will be biomarkers a MedDiet intervention related to the response, we investigated this relationship according sex apolipoprotein E ( APOE)...
Animal studies point to an implication of the endocannabinoid system on executive functions. In humans, several have suggested association between acute or chronic use exogenous cannabinoids (Δ9-tetrahydrocannabinol) and impairments. However, date, no published reports establish relationship endocannabinoids, as biomarkers cannabinoid neurotransmission system, functioning in humans. The aim present study was explore circulating levels plasma endocannabinoids N-arachidonoylethanolamine (AEA)...