A5022491022- Neurotransmitter Receptor Influence on Behavior
- Functional Brain Connectivity Studies
- Neuroscience and Neuropharmacology Research
- Musculoskeletal pain and rehabilitation
- Heart Rate Variability and Autonomic Control
- Pain Mechanisms and Treatments
- Receptor Mechanisms and Signaling
- Ion channel regulation and function
- Pain Management and Placebo Effect
- Mindfulness and Compassion Interventions
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neural dynamics and brain function
- Advanced Neuroimaging Techniques and Applications
- Personality Disorders and Psychopathology
- Electron Spin Resonance Studies
- Neural and Behavioral Psychology Studies
- Memory and Neural Mechanisms
- Decision-Making and Behavioral Economics
- Substance Abuse Treatment and Outcomes
- Neuropeptides and Animal Physiology
- Advanced MRI Techniques and Applications
- Mental Health and Psychiatry
- Lanthanide and Transition Metal Complexes
- Marine Biology and Environmental Chemistry
- Pain Management and Opioid Use
University of Florida Health
2019-2025
University of Florida
2016-2021
Mayo Clinic in Florida
2014
Mayo Clinic
2014
Auburn University
2012
Abstract Background Pain and substance use are frequently comorbid have been shown to exert bidirectional effects. Self-medication of pain distress via is common can be understood negative reinforcement, ultimately strengthening the pathway between over time. As such, a testable model potentially modifiable candidate mechanisms that underlie needed. Purpose This review proposes as an antecedent guide future research inform clinical practice. Methods An integrative current evidence regarding...
Glutamate neurotransmission in the nucleus accumbens core (NAc) mediates ethanol consumption. Previous studies using non-contingent and voluntary alcohol administration inbred rodents have reported increased basal extracellular glutamate levels NAc. Here, we assessed NAc following intermittent consumption male Sprague-Dawley rats that had access to for 7 weeks on alternating days. We found at 24 h withdrawal from thus sought identify source of this glutamate. To do so, employed a combination...
Abstract Background The insular cortex (IC), which includes anterior (AIC) and posterior (PIC) subdivisions, plays a role in numerous functions behaviors, including chronic alcohol consumption. This study investigated acute effects on functional connectivity (FC) of the IC healthy social drinkers. We hypothesized that consumption would significantly disrupt resting‐state FC (rsFC) with whole brain differentially modulate rsFC AIC PIC. also examined association alcohol‐induced changes...
Preclinical models of cocaine use disorder are widely utilized to identify neuroadaptations underlying seeking and screen medications reduce seeking. However, while the majority users engage in poly-substance (PSU), a minority preclinical studies employ PSU models. We previously reported that when rats consume alcohol after daily intravenous self-administration, nucleus accumbens (NA) core basal glutamate levels reduced below those consumed only cocaine, do not increase during...
The aim of this work was to develop simultaneous edited MRS γ‐aminobutyric acid (GABA), glutathione (GSH), and ethanol (EtOH) using Hadamard encoding reconstruction MEGA‐edited spectroscopy (HERMES) at 3T. Density‐matrix simulations HERMES were carried out compared with phantom experiments. In vivo experiments performed in six healthy volunteers about 30 min after alcohol consumption. Simulations showed GABA‐, GSH‐, EtOH‐edited spectra low levels crosstalk excellent agreement spectra. well...
Objective: The goal of this study was to determine whether the acute analgesic effects alcohol intake are moderated by tolerance, characterized differing subjective and neurobehavioral a given blood concentration (BAC) depending on BAC is rising or falling. Method: Twenty-nine healthy drinkers (20 women) completed two laboratory sessions in which they consumed beverage: active (target BAC= .08 g/dl) placebo. Acute tolerance assessed examining main interactive beverage condition assessment...
Self-medication of pain with alcohol is prevalent, and expectancies for analgesia likely influence relief consumption. Hazardous use has been associated greater delay discounting rates; however, little known about the relationship between analgesia. Therefore, present study examined sex differences in associations Healthy drinkers without chronic (N = 53) completed measures analgesia, use, outcome expectancies. A five-trial adjusting-delay task (DDT) monetary outcomes was also administered....
Traditional pain interventions limit fluctuations in sensation, which may paradoxically impair endogenous modulatory systems (EPMS). However, controlled exposures to clinically relevant (e.g. delayed onset muscle soreness [DOMS]) build capacity the EPMS. Emerging evidence suggests that regional signal variability (RSV) be an important indicator of efficiency and within brain regions. This study sought determine role RSV both susceptibility trainability response following repeated DOMS...
Tobacco usage typically precedes illicit drug use in adolescent and young adult populations. Several animal studies suggest nicotine increases the risk for subsequent cocaine abuse, may be a negative prognostic factor treatment of addiction; i.e., "gateway drug". Neurotensin (NT) is 13-amino acid neuropeptide that modulates dopamine, acetylcholine, glutamate, GABA neurotransmission brain reward pathways. NT69L, NT(8-13) analog, blocks behavioral sensitization (an model psychostimulant...
Background Acute alcohol intoxication has wide‐ranging neurobehavioral effects on psychomotor, attentional, inhibitory, and memory‐related cognitive processes. These are mirrored in disruption of neural metabolism, functional activation, network coherence. Metrics intraregional dynamics such as regional signal variability (RSV) brain entropy (BEN) may capture unique aspects capacity healthy clinical populations; however, alcohol’s influence these metrics is unclear. The present study aimed...